Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase pim-1 (313/313 = 100%)† (Homo sapiens (Human)) | BDBM26673 (6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Valeant Pharmaceuticals Research and Development | Assay Description PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was... | Bioorg Med Chem Lett 17: 1679-83 (2007) Article DOI: 10.1016/j.bmcl.2006.12.086 BindingDB Entry DOI: 10.7270/Q2CV4G2V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (313/313 = 100%)† (Homo sapiens (Human)) | BDBM26673 (6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Competitive inhibition of PIM1 in presence of ATP | J Med Chem 55: 8199-208 (2012) Article DOI: 10.1021/jm3009234 BindingDB Entry DOI: 10.7270/Q2930V9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (313/313 = 100%)† (Homo sapiens (Human)) | BDBM26673 (6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo Curated by ChEMBL | Assay Description Inhibition of PIM1 | Eur J Med Chem 45: 90-7 (2010) Article DOI: 10.1016/j.ejmech.2009.09.029 BindingDB Entry DOI: 10.7270/Q20K28N2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (313/313 = 100%)† (Homo sapiens (Human)) | BDBM26673 (6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet... | Bioorg Med Chem Lett 19: 3019-22 (2009) Article DOI: 10.1016/j.bmcl.2009.04.061 BindingDB Entry DOI: 10.7270/Q21J99PJ | |||||||||||
More data for this Ligand-Target Pair |