Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase Lck (271/271 = 100%)† (Homo sapiens (Human)) | BDBM17714 (5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of Lck | Bioorg Med Chem Lett 17: 2305-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.057 BindingDB Entry DOI: 10.7270/Q2697365 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase Lck (271/271 = 100%)† (Homo sapiens (Human)) | BDBM17714 (5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen | Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all... | Bioorg Med Chem Lett 17: 2299-304 (2007) Article DOI: 10.1016/j.bmcl.2007.01.048 BindingDB Entry DOI: 10.7270/Q2X34VQ9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |