PDB code 2Y0J
Identical Ligands in BindingDB
Found 2 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(333/333 = 100%)† (Homo sapiens (Human)) | BDBM50334653
(5-((1H-benzo[d]imidazol-2-yl)methylthio)-2-methyl-...)Show InChI InChI=1S/C18H14N6S/c1-11-19-17-12-6-2-3-7-13(12)22-18(24(17)23-11)25-10-16-20-14-8-4-5-9-15(14)21-16/h2-9H,10H2,1H3,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 21: 3738-42 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.067 BindingDB Entry DOI: 10.7270/Q24B31PT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(333/333 = 100%)† (Homo sapiens (Human)) | BDBM50334653
(5-((1H-benzo[d]imidazol-2-yl)methylthio)-2-methyl-...)Show InChI InChI=1S/C18H14N6S/c1-11-19-17-12-6-2-3-7-13(12)22-18(24(17)23-11)25-10-16-20-14-8-4-5-9-15(14)21-16/h2-9H,10H2,1H3,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Sassari
Curated by ChEMBL
| Assay Description Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assay |
Bioorg Med Chem 19: 642-9 (2011)
Article DOI: 10.1016/j.bmc.2010.10.038 BindingDB Entry DOI: 10.7270/Q2TT4R73 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
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* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output