Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity protein kinase TTK (290/293 = 99%)† (Homo sapiens (Human)) | BDBM36485 (1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | n/a | n/a | 367 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Dana-Farber Cancer Institute | Assay Description ATP-site competition binding assay using Mps1 Kinase inhibitors in LanthaScreen Eu time-resolved FRET (TR-FRET) technology from Invitrogen. | Nat Chem Biol 6: 359-68 (2010) Article DOI: 10.1038/nchembio.345 BindingDB Entry DOI: 10.7270/Q27D2SGG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dual specificity protein kinase TTK (290/293 = 99%)† (Homo sapiens (Human)) | BDBM36485 (1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University Curated by ChEMBL | Assay Description Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure... | Bioorg Med Chem 25: 2156-2166 (2017) Article DOI: 10.1016/j.bmc.2017.02.030 BindingDB Entry DOI: 10.7270/Q2571FGM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |