Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (304/304 = 100%)† (Homo sapiens (Human)) | BDBM50302901 (7-methoxy-N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassay | Bioorg Med Chem Lett 19: 6307-12 (2009) Article DOI: 10.1016/j.bmcl.2009.09.096 BindingDB Entry DOI: 10.7270/Q2DV1JZH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (304/304 = 100%)† (Homo sapiens (Human)) | BDBM50302901 (7-methoxy-N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of c-Met by HTRF assay | Bioorg Med Chem Lett 19: 6307-12 (2009) Article DOI: 10.1016/j.bmcl.2009.09.096 BindingDB Entry DOI: 10.7270/Q2DV1JZH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |