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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dihydroorotate dehydrogenase (quinone), mitochondrial (382/412 = 93%)† (Plasmodium falciparum (isolate 3D7)) | BDBM28817 (5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]tria...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet  | Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | 8.0 | 20 |
University of Washington at Seattle | Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect... | J Med Chem 52: 1864-72 (2009) Article DOI: 10.1021/jm801343r BindingDB Entry DOI: 10.7270/Q2QN653C | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (382/412 = 93%)† (Plasmodium falciparum (isolate 3D7)) | BDBM28817 (5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]tria...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard School of Public Health | Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ... | J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
