Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutaminyl-peptide cyclotransferase (329/329 = 100%)† (Homo sapiens (Human)) | BDBM7918 (1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Probiodrug AG | Assay Description QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM... | J Med Chem 49: 664-77 (2006) Article DOI: 10.1021/jm050756e BindingDB Entry DOI: 10.7270/Q28S4N46 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminyl-peptide cyclotransferase (329/329 = 100%)† (Homo sapiens (Human)) | BDBM7918 (1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Probiodrug AG Curated by ChEMBL | Assay Description Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assay | J Med Chem 52: 7069-80 (2009) Article DOI: 10.1021/jm900969p BindingDB Entry DOI: 10.7270/Q2Q2409C | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminyl-peptide cyclotransferase (329/329 = 100%)† (Homo sapiens (Human)) | BDBM7918 (1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 95 | -40.1 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Academia Sinica | Assay Description The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat... | J Biol Chem 286: 12439-49 (2011) Article DOI: 10.1074/jbc.M110.208595 BindingDB Entry DOI: 10.7270/Q2CN72HS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminyl-peptide cyclotransferase (329/329 = 100%)† (Homo sapiens (Human)) | BDBM7918 (1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.82E+3 | -32.8 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Academia Sinica | Assay Description The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat... | J Biol Chem 286: 12439-49 (2011) Article DOI: 10.1074/jbc.M110.208595 BindingDB Entry DOI: 10.7270/Q2CN72HS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminyl-peptide cyclotransferase (329/329 = 100%)† (Homo sapiens (Human)) | BDBM7918 (1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenzhen University Curated by ChEMBL | Assay Description Inhibition of human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-Gln-H substrate measured for 15 mins by spectrophotometr... | Bioorg Med Chem 24: 2280-6 (2016) Article DOI: 10.1016/j.bmc.2016.03.064 BindingDB Entry DOI: 10.7270/Q2P55QDH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |