Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutaminase kidney isoform, mitochondrial (480/480 = 100%)† (Homo sapiens (Human)) | BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description Inhibition of recombinant human His-tagged KGA (L123 to L669 residues) expressed in Escherichia coli BL21(DE3)pLysS using glutamine substrate preincu... | J Med Chem 60: 5599-5612 (2017) Article DOI: 10.1021/acs.jmedchem.7b00282 BindingDB Entry DOI: 10.7270/Q26H4KP5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (480/480 = 100%)† (Homo sapiens (Human)) | BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Calithera Biosciences Inc. US Patent | Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th... | US Patent US8604016 (2013) BindingDB Entry DOI: 10.7270/Q2CC0ZBW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (480/480 = 100%)† (Homo sapiens (Human)) | BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th... | J Med Chem 51: 1681-94 (2008) BindingDB Entry DOI: 10.7270/Q2JS9SQV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (480/480 = 100%)† (Homo sapiens (Human)) | BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Calithera Biosciences Inc. US Patent | Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th... | US Patent US8604016 (2013) BindingDB Entry DOI: 10.7270/Q2CC0ZBW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (480/480 = 100%)† (Homo sapiens (Human)) | BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description No preinc (Column 4). | J Med Chem 51: 1681-94 (2008) BindingDB Entry DOI: 10.7270/Q2JS9SQV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (480/480 = 100%)† (Homo sapiens (Human)) | BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 371 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Inhibition of recombinant HIs-tagged human GAC (residue 72-603 aa) expressed in Escherichia coli after 10 mins using glutamine as substrate | Bioorg Med Chem 24: 1819-39 (2016) Article DOI: 10.1016/j.bmc.2016.03.009 BindingDB Entry DOI: 10.7270/Q2DZ0B5C | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (480/480 = 100%)† (Homo sapiens (Human)) | BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University Curated by ChEMBL | Assay Description Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay | J Med Chem 55: 10551-63 (2012) Article DOI: 10.1021/jm301191p BindingDB Entry DOI: 10.7270/Q2VD70M7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (480/480 = 100%)† (Homo sapiens (Human)) | BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Huazhong University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of recombinant KGA (unknown origin) using glutamine as substrate | Bioorg Med Chem Lett 27: 1243-1246 (2017) Article DOI: 10.1016/j.bmcl.2017.01.057 BindingDB Entry DOI: 10.7270/Q2639S0F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |