Found 4 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cell division protein FtsZ
(389/389 = 100%)† (Staphylococcus aureus) | BDBM50079356
(CHEMBL511201)Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus FtsZ GTPase activity |
Eur J Med Chem 95: 1-15 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.026 BindingDB Entry DOI: 10.7270/Q2S75J14 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cell division protein FtsZ
(389/389 = 100%)† (Staphylococcus aureus) | BDBM50079356
(CHEMBL511201)Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Prolysis
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus FtsZ GTPase activity |
Science 321: 1673-5 (2008)
Article DOI: 10.1126/science.1159961 BindingDB Entry DOI: 10.7270/Q2HX1GG1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cell division protein FtsZ
(389/389 = 100%)† (Staphylococcus aureus) | BDBM50079356
(CHEMBL511201)Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Stony Brook University
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus FtsZ GTPase activity |
Bioorg Med Chem 24: 6354-6369 (2016)
Article DOI: 10.1016/j.bmc.2016.05.003 BindingDB Entry DOI: 10.7270/Q2SN0BZ0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cell division protein FtsZ
(389/389 = 100%)† (Staphylococcus aureus) | BDBM50079356
(CHEMBL511201)Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
University of California at Davis
Curated by ChEMBL
| Assay Description Activation of Staphylococcus aureus FtsZ GTPase activity |
ACS Med Chem Lett 6: 308-12 (2015)
Article DOI: 10.1021/ml500497s BindingDB Entry DOI: 10.7270/Q2PV6N4C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |