Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (397/397 = 100%)† (Homo sapiens (Human)) | BDBM50432510 (CHEMBL2349470) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Curated by ChEMBL | Assay Description Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly... | J Med Chem 56: 3379-403 (2013) Article DOI: 10.1021/jm4002154 BindingDB Entry DOI: 10.7270/Q2JD4Z52 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-secretase 1 (397/397 = 100%)† (Homo sapiens (Human)) | BDBM50432510 (CHEMBL2349470) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Curated by ChEMBL | Assay Description Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly... | J Med Chem 56: 3379-403 (2013) Article DOI: 10.1021/jm4002154 BindingDB Entry DOI: 10.7270/Q2JD4Z52 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-secretase 1 (397/397 = 100%)† (Homo sapiens (Human)) | BDBM50432510 (CHEMBL2349470) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a |
Array BioPharma Curated by ChEMBL | Assay Description Inhibition of BACE1 in HEK293 cells expressing wild type APP assessed as level of amyloid beta (1 to 40) after 48 hrs by HTRF assay | J Med Chem 56: 3379-403 (2013) Article DOI: 10.1021/jm4002154 BindingDB Entry DOI: 10.7270/Q2JD4Z52 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-secretase 1 (397/397 = 100%)† (Homo sapiens (Human)) | BDBM50432510 (CHEMBL2349470) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Array BioPharma Curated by ChEMBL | Assay Description Inhibition of BACE1 in HEK293 cells expressing wild type APP assessed as level of amyloid beta (1 to 40) after 48 hrs by HTRF assay | J Med Chem 56: 3379-403 (2013) Article DOI: 10.1021/jm4002154 BindingDB Entry DOI: 10.7270/Q2JD4Z52 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |