Affinity Data by PDB ID

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PDB code 4Q5V

Identical Ligands in BindingDB

Found 6 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
DNA polymerase alpha catalytic subunit (921/922 > 99%)^† (Homo sapiens (Human))	BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone \| 6,13-di...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysis				J Med Chem 60: 5424-5437 (2017) Article DOI: 10.1021/acs.jmedchem.7b00067 BindingDB Entry DOI: 10.7270/Q2BZ6873
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA polymerase alpha catalytic subunit (921/922 > 99%)^† (Homo sapiens (Human))	BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone \| 6,13-di...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
Pharmacia Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA polymerase alpha catalytic subunit (921/922 > 99%)^† (Homo sapiens (Human))	BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone \| 6,13-di...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha				Bioorg Med Chem Lett 20: 3039-42 (2010) Article DOI: 10.1016/j.bmcl.2010.03.115 BindingDB Entry DOI: 10.7270/Q2000281
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA polymerase alpha catalytic subunit (921/922 > 99%)^† (Homo sapiens (Human))	BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone \| 6,13-di...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against Human alpha polymerase				Bioorg Med Chem Lett 10: 2079-81 (2000) BindingDB Entry DOI: 10.7270/Q2222T0M
Pharmacia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA polymerase alpha catalytic subunit (921/922 > 99%)^† (Homo sapiens (Human))	BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone \| 6,13-di...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
303A College Road East Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...				Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S
303A College Road East Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA polymerase alpha catalytic subunit (921/922 > 99%)^† (Homo sapiens (Human))	BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone \| 6,13-di...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against DNA polymerase alpha				J Med Chem 36: 3503-10 (1994) BindingDB Entry DOI: 10.7270/Q2HT2PXP
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output