Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-C chemokine receptor type 2 (73/82 = 89%)† (Homo sapiens (Human)) | BDBM50089354 (CHEMBL3577945) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity against CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis at 37 degC | ACS Med Chem Lett 6: 439-44 (2015) Article DOI: 10.1021/ml500505q BindingDB Entry DOI: 10.7270/Q2668FWM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
C-C chemokine receptor type 2 (73/82 = 89%)† (Homo sapiens (Human)) | BDBM50089354 (CHEMBL3577945) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 25 |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Inhibition of [125I]hMCP1 binding to CCR2 in human PBMC incubated for 30 mins at room temperature | ACS Med Chem Lett 6: 439-44 (2015) Article DOI: 10.1021/ml500505q BindingDB Entry DOI: 10.7270/Q2668FWM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
C-C chemokine receptor type 2 (73/82 = 89%)† (Homo sapiens (Human)) | BDBM50089354 (CHEMBL3577945) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity against CCR2 in whole blood (unknown origin) assessed as reduction in CD11b upregulation | ACS Med Chem Lett 6: 439-44 (2015) Article DOI: 10.1021/ml500505q BindingDB Entry DOI: 10.7270/Q2668FWM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |