Affinity Data by PDB ID

PDB code 4EJ4

Identical Ligands in BindingDB

Found 10 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Delta-type opioid receptor (199/199 = 100%)^† (MOUSE)	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Antagonist activity of compound on agonist stimulated [35S]GTP-gamma-S binding on delta-opioid receptor				J Med Chem 44: 1471-4 (2001) BindingDB Entry DOI: 10.7270/Q2PK0GVP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (88/92 = 96%)^† (Homo sapiens (Human))	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	0.0310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity to opioid receptor delta using [3H]DADLE as radioligand in guinea pig brain membrane				J Med Chem 34: 1715-20 (1991) BindingDB Entry DOI: 10.7270/Q2T43TPG
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (88/92 = 96%)^† (Homo sapiens (Human))	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting met...				Bioorg Med Chem 22: 4067-72 (2014) Article DOI: 10.1016/j.bmc.2014.05.065 BindingDB Entry DOI: 10.7270/Q2JM2C8P
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (90/92 = 98%)^† (Rattus norvegicus (rat))	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Medicine& Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS) Curated by ChEMBL					Assay Description Binding affinity against Opioid receptor delta 1 from rat brain membranes using [3H]DADLE				J Med Chem 48: 1620-9 (2005) Checked by Author Article DOI: 10.1021/jm049117e BindingDB Entry DOI: 10.7270/Q2ZP47MP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (199/199 = 100%)^† (MOUSE)	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Displacement of [3H]DADLE at delta-opioid receptor				J Med Chem 44: 1471-4 (2001) BindingDB Entry DOI: 10.7270/Q2PK0GVP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (88/92 = 96%)^† (Homo sapiens (Human))	BDBM86662 (CAS_111555-53-4 \| NALTRINDOLE \| NSC_3034754) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
I.G.B.M.C. Curated by PDSP K_i Database									J Pharmacol Exp Ther 313: 410-21 (2005) Article DOI: 10.1124/jpet.104.077321 BindingDB Entry DOI: 10.7270/Q2XD107N
I.G.B.M.C. Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (88/92 = 96%)^† (Homo sapiens (Human))	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.457	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Displacement of [3H]DPDPE from human DOR expressed in CHO cells				Bioorg Med Chem Lett 25: 2927-30 (2015) Article DOI: 10.1016/j.bmcl.2015.05.038 BindingDB Entry DOI: 10.7270/Q28C9Z0W
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (88/92 = 96%)^† (Homo sapiens (Human))	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Displacement of [3H]DADLE from delta opioid receptor (unknown origin) expressed in HEK293T cells after 1.5 hrs by radioligand binding assay				Eur J Med Chem 85: 818-29 (2014) Article DOI: 10.1016/j.ejmech.2014.07.077 BindingDB Entry DOI: 10.7270/Q2VH5QDH
University of Mississippi Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (88/92 = 96%)^† (Homo sapiens (Human))	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Displacement of [3H]DADLE from delta opioid receptor (unknown origin)				Bioorg Med Chem Lett 23: 2860-2 (2013) Article DOI: 10.1016/j.bmcl.2013.03.111 BindingDB Entry DOI: 10.7270/Q22V2K13
University of Mississippi Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (199/199 = 100%)^† (MOUSE)	BDBM50370067 (CHEMBL1237164) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	2.63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cells				ACS Med Chem Lett 3: 640-644 (2012) Article DOI: 10.1021/ml300083p BindingDB Entry DOI: 10.7270/Q2BR8T8V
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output