Found 18 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamate receptor ionotropic, NMDA 1/2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]-ifenprodil from GluN1a/GluN2B (unknown origin) expressed in L(tk-) cell membranes after 120 mins by scintillation counting analy... |
Eur J Med Chem 157: 397-404 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.003 BindingDB Entry DOI: 10.7270/Q2XG9TTX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]Ifenprodil from GluN2B receptor (unknown origin) expressed in mouse L(tk-) cell membranes incubated for 120 mins measured for 5 m... |
Eur J Med Chem 144: 672-681 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.054 BindingDB Entry DOI: 10.7270/Q2B56NDZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cells co-expressing GluN1a after 120 mins by scintillation counting method |
Bioorg Med Chem 22: 6638-46 (2015)
Article DOI: 10.1016/j.bmc.2014.10.004 BindingDB Entry DOI: 10.7270/Q2ZW1NH7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(362/364 > 99%)† (Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Louis Pasteur de Strasbourg
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from rat brain membrane NR2B receptor |
Bioorg Med Chem Lett 18: 2765-70 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.019 BindingDB Entry DOI: 10.7270/Q21C1XR4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(362/364 > 99%)† (Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from Wistar rat cerebral cortex glutamate NMDA receptor GluN2B subunit after 120 mins by scintillation counting analys... |
Bioorg Med Chem 22: 393-7 (2013)
Article DOI: 10.1016/j.bmc.2013.11.014 BindingDB Entry DOI: 10.7270/Q2M32X79 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(362/364 > 99%)† (Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hamamatsu University School of Medicine
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from NR2B receptor in rat cortical synaptic membranes |
Bioorg Med Chem 18: 7497-506 (2010)
Article DOI: 10.1016/j.bmc.2010.08.053 BindingDB Entry DOI: 10.7270/Q2MS3T06 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(362/364 > 99%)† (Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation counting |
J Med Chem 55: 9708-21 (2012)
Article DOI: 10.1021/jm3009458 BindingDB Entry DOI: 10.7270/Q2VQ33TR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(362/364 > 99%)† (Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex after 120 mins |
J Med Chem 55: 10532-9 (2012)
Article DOI: 10.1021/jm301508d BindingDB Entry DOI: 10.7270/Q2RN3919 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(362/364 > 99%)† (Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040 BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(362/364 > 99%)† (Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Messina
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from NMDA NR2B receptor in Wistar rat cerebral cortex membrane |
Bioorg Med Chem 17: 1640-7 (2009)
Article DOI: 10.1016/j.bmc.2008.12.058 BindingDB Entry DOI: 10.7270/Q2D21XGV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(362/364 > 99%)† (Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB
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| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Farmaceutiche ed Ambientali (CHIBIOFARAM) Universit£ degli Studi di Messina
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from Wistar rat cerebral cortex GluN2B receptor after 120 mins |
Bioorg Med Chem 24: 1513-9 (2016)
Article DOI: 10.1016/j.bmc.2016.02.021 BindingDB Entry DOI: 10.7270/Q26M38P3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1/2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
I2BM
Curated by ChEMBL
| Assay Description Antagonist activity at NR1/NR2B receptor assessed as inhibition of Glu/Gly induced Ca2+ influx |
Eur J Med Chem 46: 2295-309 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.013 BindingDB Entry DOI: 10.7270/Q2M32ZMN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1/2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Louis Pasteur de Strasbourg
Curated by ChEMBL
| Assay Description Inhibition of NR1/NR2B receptor expressed in xenopus oocytes assessed as effect on L-glutamate and glycine-induced current response |
Bioorg Med Chem Lett 18: 2765-70 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.019 BindingDB Entry DOI: 10.7270/Q21C1XR4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1/2B
(362/364 > 99%)† (Rattus norvegicus (Rat)-RAT) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
KEGG
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc.
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes |
J Med Chem 42: 2993-3000 (1999)
Article DOI: 10.1021/jm990246i BindingDB Entry DOI: 10.7270/Q2RX9B8W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1/2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
I2BM
Curated by ChEMBL
| Assay Description Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influx |
Eur J Med Chem 46: 2295-309 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.013 BindingDB Entry DOI: 10.7270/Q2M32ZMN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1/2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Paris Descartes
Curated by ChEMBL
| Assay Description Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-el... |
Bioorg Med Chem Lett 20: 5552-8 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.043 BindingDB Entry DOI: 10.7270/Q24M97C9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1/2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
I2BM
Curated by ChEMBL
| Assay Description Antagonist activity against NR1/NR2B receptor expressed in xenopus oocytes assessed as inhibition of NMDA induced Ca2+ influx |
Eur J Med Chem 46: 2295-309 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.013 BindingDB Entry DOI: 10.7270/Q2M32ZMN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(363/364 > 99%)† (Homo sapiens (Human)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards human NR2B receptor |
Bioorg Med Chem Lett 13: 697-700 (2003)
BindingDB Entry DOI: 10.7270/Q2FX78TP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |