Affinity Data by PubMed id=10091697

PubMed code 10091697

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prothrombin (Homo sapiens (Human))	BDBM50075121 (5-[(3aS,8aS)-5-(4-Hydroxy-phenyl)-2-oxo-3,3a,8,8a-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human thrombin was determined				Bioorg Med Chem Lett 9: 431-6 (1999) BindingDB Entry DOI: 10.7270/Q26T0KS3
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50075122 (5-((3aS,8aS)-2-Oxo-3,3a,8,8a-tetrahydro-2H-indeno[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human thrombin was determined				Bioorg Med Chem Lett 9: 431-6 (1999) BindingDB Entry DOI: 10.7270/Q26T0KS3
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50072293 (5-((3R,3aR,6aS)-2-Oxo-hexahydro-cyclopenta[b]furan...) Show SMILES NC(=N)CCCC[C@@H]1[C@H]2CCC[C@@H]2OC1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human thrombin was determined				Bioorg Med Chem Lett 9: 431-6 (1999) BindingDB Entry DOI: 10.7270/Q26T0KS3
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50075123 (4-((3R,3aS,8aS)-2-Oxo-3,3a,8,8a-tetrahydro-2H-inde...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human thrombin was determined				Bioorg Med Chem Lett 9: 431-6 (1999) BindingDB Entry DOI: 10.7270/Q26T0KS3
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50075120 (5-[(3R,3aS,8aS)-5-(4-Hydroxy-phenyl)-2-oxo-3,3a,8,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human thrombin was determined				Bioorg Med Chem Lett 9: 431-6 (1999) BindingDB Entry DOI: 10.7270/Q26T0KS3
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50075119 (5-[(3aR,8aS)-6-(3-Methoxy-phenyl)-3-methyl-2-oxo-3...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Inhibitory activity of the compound against human thrombin was determined				Bioorg Med Chem Lett 9: 431-6 (1999) BindingDB Entry DOI: 10.7270/Q26T0KS3
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%