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PubMed code 10450965

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50072184
PNG
(CHEMBL292567 | Phosphoric acid mono-(4-{(S)-2-acet...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C20H30N5O9P/c1-10(2)17(20(30)24-14(18(22)28)9-16(21)27)25-19(29)15(23-11(3)26)8-12-4-6-13(7-5-12)34-35(31,32)33/h4-7,10,14-15,17H,8-9H2,1-3H3,(H2,21,27)(H2,22,28)(H,23,26)(H,24,30)(H,25,29)(H2,31,32,33)/t14-,15-,17-/m0/s1
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KEGG

UniProtKB/SwissProt

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KEGG
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4.32E+3n/an/an/an/an/an/a



Novartis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Grb2 SH2 domain binding to phospho-EGF receptor intracellular C-terminal domain

Bioorg Med Chem Lett 9: 1973-8 (1999)


BindingDB Entry DOI: 10.7270/Q26W9985
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50079648
PNG
(CHEMBL61048 | Phosphoric acid mono-{4-[2-(4-amino-...)
Show SMILES Cc1sc(nc1-c1ccc(OP(O)(O)=O)cc1)-c1nccc(N)n1
Show InChI InChI=1S/C14H13N4O4PS/c1-8-12(9-2-4-10(5-3-9)22-23(19,20)21)18-14(24-8)13-16-7-6-11(15)17-13/h2-7H,1H3,(H2,15,16,17)(H2,19,20,21)
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KEGG

UniProtKB/SwissProt

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DrugBank
antibodypedia
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PC cid
PC sid
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PubMed
n/an/a 2.59E+4n/an/an/an/an/an/a



Novartis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Grb2 SH2 domain binding to phospho-EGF receptor intracellular C-terminal domain

Bioorg Med Chem Lett 9: 1973-8 (1999)


BindingDB Entry DOI: 10.7270/Q26W9985
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50072186
PNG
(CHEMBL61047 | Phosphoric acid mono-[4-((S)-2-acety...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C17H24N5O9P/c1-9(23)21-13(6-10-2-4-11(5-3-10)31-32(28,29)30)17(27)20-8-15(25)22-12(16(19)26)7-14(18)24/h2-5,12-13H,6-8H2,1H3,(H2,18,24)(H2,19,26)(H,20,27)(H,21,23)(H,22,25)(H2,28,29,30)/t12-,13-/m0/s1
PDB
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KEGG

UniProtKB/SwissProt

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DrugBank
antibodypedia
GoogleScholar
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CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 6.70E+4n/an/an/an/an/an/a



Novartis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Grb2 SH2 domain binding to phospho-EGF receptor intracellular C-terminal domain

Bioorg Med Chem Lett 9: 1973-8 (1999)


BindingDB Entry DOI: 10.7270/Q26W9985
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50079647
PNG
(CHEMBL291304 | Phosphoric acid mono-{4-[2-(4-amino...)
Show SMILES Nc1ccnc(NCCc2ccc(OP(O)(O)=O)cc2)n1
Show InChI InChI=1S/C12H15N4O4P/c13-11-6-8-15-12(16-11)14-7-5-9-1-3-10(4-2-9)20-21(17,18)19/h1-4,6,8H,5,7H2,(H2,17,18,19)(H3,13,14,15,16)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Novartis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Grb2 SH2 domain binding to phospho-EGF receptor intracellular C-terminal domain

Bioorg Med Chem Lett 9: 1973-8 (1999)


BindingDB Entry DOI: 10.7270/Q26W9985
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%