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PubMed code 10479286

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
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 0.410n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50123273
PNG
(19-cyclopropylmethyl-(2S,10R)-11-oxa-8,19-diazahex...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)c1ncccc1C[C@@]35O
Show InChI InChI=1S/C23H24N2O3/c26-16-6-5-14-10-17-23(27)11-15-2-1-8-24-19(15)21-22(23,18(14)20(16)28-21)7-9-25(17)12-13-3-4-13/h1-2,5-6,8,13,17,21,26-27H,3-4,7,9-12H2/t17-,21+,22+,23-/m1/s1
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 0.780n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001196
PNG
(CHEMBL610522)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cc(cnc21)-c1ccccc1)ccc3O |r,THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H28N2O3/c32-22-9-8-19-13-23-29(33)14-20-12-21(18-4-2-1-3-5-18)15-30-25(20)27-28(29,24(19)26(22)34-27)10-11-31(23)16-17-6-7-17/h1-5,8-9,12,15,17,23,27,32-33H,6-7,10-11,13-14,16H2/t23-,27+,28+,29-/m1/s1
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 0.870n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50123273
PNG
(19-cyclopropylmethyl-(2S,10R)-11-oxa-8,19-diazahex...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)c1ncccc1C[C@@]35O
Show InChI InChI=1S/C23H24N2O3/c26-16-6-5-14-10-17-23(27)11-15-2-1-8-24-19(15)21-22(23,18(14)20(16)28-21)7-9-25(17)12-13-3-4-13/h1-2,5-6,8,13,17,21,26-27H,3-4,7,9-12H2/t17-,21+,22+,23-/m1/s1
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 1.5n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001190
PNG
(CHEMBL2112576)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1ccc(nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H28N2O3/c32-22-11-9-19-14-23-29(33)15-20-8-10-21(18-4-2-1-3-5-18)30-25(20)27-28(29,24(19)26(22)34-27)12-13-31(23)16-17-6-7-17/h1-5,8-11,17,23,27,32-33H,6-7,12-16H2/t23-,27+,28+,29-/m1/s1
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 1.80n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001195
PNG
(CHEMBL610261)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cc(cnc21)-c1ccc(Cl)cc1)ccc3O |r,THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H27ClN2O3/c30-21-6-3-17(4-7-21)20-11-19-13-29(34)23-12-18-5-8-22(33)26-24(18)28(29,27(35-26)25(19)31-14-20)9-10-32(23)15-16-1-2-16/h3-8,11,14,16,23,27,33-34H,1-2,9-10,12-13,15H2/t23-,27+,28+,29-/m1/s1
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 2.20n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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 2.5n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50001196
PNG
(CHEMBL610522)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cc(cnc21)-c1ccccc1)ccc3O |r,THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H28N2O3/c32-22-9-8-19-13-23-29(33)14-20-12-21(18-4-2-1-3-5-18)15-30-25(20)27-28(29,24(19)26(22)34-27)10-11-31(23)16-17-6-7-17/h1-5,8-9,12,15,17,23,27,32-33H,6-7,10-11,13-14,16H2/t23-,27+,28+,29-/m1/s1
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 3.40n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency measured as Ke = [antagonist]/(IC50 ratio-1) against delta opioid receptor from mouse vas deferens (MVD) using DPDPE

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001173
PNG
(CHEMBL2112572)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cncnc21)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C22H23N3O3/c26-15-4-3-13-7-16-22(27)8-14-9-23-11-24-18(14)20-21(22,17(13)19(15)28-20)5-6-25(16)10-12-1-2-12/h3-4,9,11-12,16,20,26-27H,1-2,5-8,10H2/t16-,20+,21+,22-/m1/s1
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 3.5n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001173
PNG
(CHEMBL2112572)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cncnc21)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C22H23N3O3/c26-15-4-3-13-7-16-22(27)8-14-9-23-11-24-18(14)20-21(22,17(13)19(15)28-20)5-6-25(16)10-12-1-2-12/h3-4,9,11-12,16,20,26-27H,1-2,5-8,10H2/t16-,20+,21+,22-/m1/s1
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 4.20n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001191
PNG
(CHEMBL2112575)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cnc(C)nc21)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C23H25N3O3/c1-12-24-10-15-9-23(28)17-8-14-4-5-16(27)20-18(14)22(23,21(29-20)19(15)25-12)6-7-26(17)11-13-2-3-13/h4-5,10,13,17,21,27-28H,2-3,6-9,11H2,1H3/t17-,21+,22+,23-/m1/s1
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 6n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001173
PNG
(CHEMBL2112572)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cncnc21)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C22H23N3O3/c26-15-4-3-13-7-16-22(27)8-14-9-23-11-24-18(14)20-21(22,17(13)19(15)28-20)5-6-25(16)10-12-1-2-12/h3-4,9,11-12,16,20,26-27H,1-2,5-8,10H2/t16-,20+,21+,22-/m1/s1
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 6.20n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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 7n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50123273
PNG
(19-cyclopropylmethyl-(2S,10R)-11-oxa-8,19-diazahex...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)c1ncccc1C[C@@]35O
Show InChI InChI=1S/C23H24N2O3/c26-16-6-5-14-10-17-23(27)11-15-2-1-8-24-19(15)21-22(23,18(14)20(16)28-21)7-9-25(17)12-13-3-4-13/h1-2,5-6,8,13,17,21,26-27H,3-4,7,9-12H2/t17-,21+,22+,23-/m1/s1
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 8.80n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001190
PNG
(CHEMBL2112576)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1ccc(nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H28N2O3/c32-22-11-9-19-14-23-29(33)15-20-8-10-21(18-4-2-1-3-5-18)30-25(20)27-28(29,24(19)26(22)34-27)12-13-31(23)16-17-6-7-17/h1-5,8-11,17,23,27,32-33H,6-7,12-16H2/t23-,27+,28+,29-/m1/s1
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 11n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001188
PNG
(CHEMBL2112571)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cnc(nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C28H27N3O3/c32-20-9-8-18-12-21-28(33)13-19-14-29-26(17-4-2-1-3-5-17)30-23(19)25-27(28,22(18)24(20)34-25)10-11-31(21)15-16-6-7-16/h1-5,8-9,14,16,21,25,32-33H,6-7,10-13,15H2/t21-,25+,27+,28-/m1/s1
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 11n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001196
PNG
(CHEMBL610522)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cc(cnc21)-c1ccccc1)ccc3O |r,THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H28N2O3/c32-22-9-8-19-13-23-29(33)14-20-12-21(18-4-2-1-3-5-18)15-30-25(20)27-28(29,24(19)26(22)34-27)10-11-31(23)16-17-6-7-17/h1-5,8-9,12,15,17,23,27,32-33H,6-7,10-11,13-14,16H2/t23-,27+,28+,29-/m1/s1
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 14n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001188
PNG
(CHEMBL2112571)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cnc(nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C28H27N3O3/c32-20-9-8-18-12-21-28(33)13-19-14-29-26(17-4-2-1-3-5-17)30-23(19)25-27(28,22(18)24(20)34-25)10-11-31(21)15-16-6-7-16/h1-5,8-9,14,16,21,25,32-33H,6-7,10-13,15H2/t21-,25+,27+,28-/m1/s1
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 16n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001190
PNG
(CHEMBL2112576)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1ccc(nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H28N2O3/c32-22-11-9-19-14-23-29(33)15-20-8-10-21(18-4-2-1-3-5-18)30-25(20)27-28(29,24(19)26(22)34-27)12-13-31(23)16-17-6-7-17/h1-5,8-11,17,23,27,32-33H,6-7,12-16H2/t23-,27+,28+,29-/m1/s1
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 18n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001196
PNG
(CHEMBL610522)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cc(cnc21)-c1ccccc1)ccc3O |r,THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H28N2O3/c32-22-9-8-19-13-23-29(33)14-20-12-21(18-4-2-1-3-5-18)15-30-25(20)27-28(29,24(19)26(22)34-27)10-11-31(23)16-17-6-7-17/h1-5,8-9,12,15,17,23,27,32-33H,6-7,10-11,13-14,16H2/t23-,27+,28+,29-/m1/s1
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 18n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001195
PNG
(CHEMBL610261)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cc(cnc21)-c1ccc(Cl)cc1)ccc3O |r,THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H27ClN2O3/c30-21-6-3-17(4-7-21)20-11-19-13-29(34)23-12-18-5-8-22(33)26-24(18)28(29,27(35-26)25(19)31-14-20)9-10-32(23)15-16-1-2-16/h3-8,11,14,16,23,27,33-34H,1-2,9-10,12-13,15H2/t23-,27+,28+,29-/m1/s1
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 20n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001188
PNG
(CHEMBL2112571)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cnc(nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C28H27N3O3/c32-20-9-8-18-12-21-28(33)13-19-14-29-26(17-4-2-1-3-5-17)30-23(19)25-27(28,22(18)24(20)34-25)10-11-31(21)15-16-6-7-16/h1-5,8-9,14,16,21,25,32-33H,6-7,10-13,15H2/t21-,25+,27+,28-/m1/s1
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 22n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001191
PNG
(CHEMBL2112575)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cnc(C)nc21)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C23H25N3O3/c1-12-24-10-15-9-23(28)17-8-14-4-5-16(27)20-18(14)22(23,21(29-20)19(15)25-12)6-7-26(17)11-13-2-3-13/h4-5,10,13,17,21,27-28H,2-3,6-9,11H2,1H3/t17-,21+,22+,23-/m1/s1
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 23n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001191
PNG
(CHEMBL2112575)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cnc(C)nc21)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C23H25N3O3/c1-12-24-10-15-9-23(28)17-8-14-4-5-16(27)20-18(14)22(23,21(29-20)19(15)25-12)6-7-26(17)11-13-2-3-13/h4-5,10,13,17,21,27-28H,2-3,6-9,11H2,1H3/t17-,21+,22+,23-/m1/s1
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 25n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
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 36n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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 40n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001196
PNG
(CHEMBL610522)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cc(cnc21)-c1ccccc1)ccc3O |r,THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H28N2O3/c32-22-9-8-19-13-23-29(33)14-20-12-21(18-4-2-1-3-5-18)15-30-25(20)27-28(29,24(19)26(22)34-27)10-11-31(23)16-17-6-7-17/h1-5,8-9,12,15,17,23,27,32-33H,6-7,10-11,13-14,16H2/t23-,27+,28+,29-/m1/s1
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 42n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
The opioid antagonist potency against PL-107 mu-opioid receptor from guinea pig ileum(GPI).Ke (nM) = [antagonist]/(IC50 ratio-1)

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001195
PNG
(CHEMBL610261)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1cc(cnc21)-c1ccc(Cl)cc1)ccc3O |r,THB:10:9:17:4.5.6|
Show InChI InChI=1S/C29H27ClN2O3/c30-21-6-3-17(4-7-21)20-11-19-13-29(34)23-12-18-5-8-22(33)26-24(18)28(29,27(35-26)25(19)31-14-20)9-10-32(23)15-16-1-2-16/h3-8,11,14,16,23,27,33-34H,1-2,9-10,12-13,15H2/t23-,27+,28+,29-/m1/s1
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 51n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50080460
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45C(Oc1c24)c1nccc(-c2ccccc2)c1C[C@@]35O
Show InChI InChI=1S/C29H28N2O3/c32-22-9-8-19-14-23-29(33)15-21-20(18-4-2-1-3-5-18)10-12-30-25(21)27-28(29,24(19)26(22)34-27)11-13-31(23)16-17-6-7-17/h1-5,8-10,12,17,23,27,32-33H,6-7,11,13-16H2/t23-,27?,28+,29-/m1/s1
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 73n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001189
PNG
(CHEMBL2112573)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c2nc2ccccc2c1-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C33H30N2O3/c36-25-13-12-21-16-26-33(37)17-23-27(20-6-2-1-3-7-20)22-8-4-5-9-24(22)34-29(23)31-32(33,28(21)30(25)38-31)14-15-35(26)18-19-10-11-19/h1-9,12-13,19,26,31,36-37H,10-11,14-18H2/t26-,31+,32+,33-/m1/s1
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 73n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001192
PNG
(CHEMBL2112568)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(cc(nc21)-c1ccccc1)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C35H32N2O3/c38-28-14-13-24-17-29-35(39)19-26-25(22-7-3-1-4-8-22)18-27(23-9-5-2-6-10-23)36-31(26)33-34(35,30(24)32(28)40-33)15-16-37(29)20-21-11-12-21/h1-10,13-14,18,21,29,33,38-39H,11-12,15-17,19-20H2/t29-,33+,34+,35-/m1/s1
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 86n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
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 99n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001194
PNG
(CHEMBL2112578)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(nc(Cc4ccccc4)nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C35H33N3O3/c39-26-14-13-24-18-27-35(40)19-25-30(23-9-5-2-6-10-23)36-28(17-21-7-3-1-4-8-21)37-31(25)33-34(35,29(24)32(26)41-33)15-16-38(27)20-22-11-12-22/h1-10,13-14,22,27,33,39-40H,11-12,15-20H2/t27-,33+,34+,35-/m1/s1
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 100n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50080470
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Cc1cc(-c2ccccc2)c2C[C@@]3(O)[C@H]4Cc5ccc(O)c6OC(c2n1)[C@]3(CCN4CC1CC1)c56
Show InChI InChI=1S/C30H30N2O3/c1-17-13-21(19-5-3-2-4-6-19)22-15-30(34)24-14-20-9-10-23(33)27-25(20)29(30,28(35-27)26(22)31-17)11-12-32(24)16-18-7-8-18/h2-6,9-10,13,18,24,28,33-34H,7-8,11-12,14-16H2,1H3/t24-,28?,29+,30-/m1/s1
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 125n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50080470
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Cc1cc(-c2ccccc2)c2C[C@@]3(O)[C@H]4Cc5ccc(O)c6OC(c2n1)[C@]3(CCN4CC1CC1)c56
Show InChI InChI=1S/C30H30N2O3/c1-17-13-21(19-5-3-2-4-6-19)22-15-30(34)24-14-20-9-10-23(33)27-25(20)29(30,28(35-27)26(22)31-17)11-12-32(24)16-18-7-8-18/h2-6,9-10,13,18,24,28,33-34H,7-8,11-12,14-16H2,1H3/t24-,28?,29+,30-/m1/s1
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 154n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50080460
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45C(Oc1c24)c1nccc(-c2ccccc2)c1C[C@@]35O
Show InChI InChI=1S/C29H28N2O3/c32-22-9-8-19-14-23-29(33)15-21-20(18-4-2-1-3-5-18)10-12-30-25(21)27-28(29,24(19)26(22)34-27)11-13-31(23)16-17-6-7-17/h1-5,8-10,12,17,23,27,32-33H,6-7,11,13-16H2/t23-,27?,28+,29-/m1/s1
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 191n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001163
PNG
(CHEMBL2112570)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(ncnc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C28H27N3O3/c32-20-9-8-18-12-21-28(33)13-19-23(17-4-2-1-3-5-17)29-15-30-24(19)26-27(28,22(18)25(20)34-26)10-11-31(21)14-16-6-7-16/h1-5,8-9,15-16,21,26,32-33H,6-7,10-14H2/t21-,26+,27+,28-/m1/s1
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 216n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001163
PNG
(CHEMBL2112570)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(ncnc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C28H27N3O3/c32-20-9-8-18-12-21-28(33)13-19-23(17-4-2-1-3-5-17)29-15-30-24(19)26-27(28,22(18)25(20)34-26)10-11-31(21)14-16-6-7-16/h1-5,8-9,15-16,21,26,32-33H,6-7,10-14H2/t21-,26+,27+,28-/m1/s1
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 230n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001194
PNG
(CHEMBL2112578)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(nc(Cc4ccccc4)nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C35H33N3O3/c39-26-14-13-24-18-27-35(40)19-25-30(23-9-5-2-6-10-23)36-28(17-21-7-3-1-4-8-21)37-31(25)33-34(35,29(24)32(26)41-33)15-16-38(27)20-22-11-12-22/h1-10,13-14,22,27,33,39-40H,11-12,15-20H2/t27-,33+,34+,35-/m1/s1
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 233n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50080461
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Cc1nc2C3Oc4c5c(C[C@H]6N(CC7CC7)CC[C@@]35[C@@]6(O)Cc2c(n1)-c1ccccc1)ccc4O
Show InChI InChI=1S/C29H29N3O3/c1-16-30-24(18-5-3-2-4-6-18)20-14-29(34)22-13-19-9-10-21(33)26-23(19)28(29,27(35-26)25(20)31-16)11-12-32(22)15-17-7-8-17/h2-6,9-10,17,22,27,33-34H,7-8,11-15H2,1H3/t22-,27?,28+,29-/m1/s1
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 254n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50080460
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45C(Oc1c24)c1nccc(-c2ccccc2)c1C[C@@]35O
Show InChI InChI=1S/C29H28N2O3/c32-22-9-8-19-14-23-29(33)15-21-20(18-4-2-1-3-5-18)10-12-30-25(21)27-28(29,24(19)26(22)34-27)11-13-31(23)16-17-6-7-17/h1-5,8-10,12,17,23,27,32-33H,6-7,11,13-16H2/t23-,27?,28+,29-/m1/s1
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 264n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001189
PNG
(CHEMBL2112573)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c2nc2ccccc2c1-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C33H30N2O3/c36-25-13-12-21-16-26-33(37)17-23-27(20-6-2-1-3-7-20)22-8-4-5-9-24(22)34-29(23)31-32(33,28(21)30(25)38-31)14-15-35(26)18-19-10-11-19/h1-9,12-13,19,26,31,36-37H,10-11,14-18H2/t26-,31+,32+,33-/m1/s1
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 272n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001189
PNG
(CHEMBL2112573)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c2nc2ccccc2c1-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C33H30N2O3/c36-25-13-12-21-16-26-33(37)17-23-27(20-6-2-1-3-7-20)22-8-4-5-9-24(22)34-29(23)31-32(33,28(21)30(25)38-31)14-15-35(26)18-19-10-11-19/h1-9,12-13,19,26,31,36-37H,10-11,14-18H2/t26-,31+,32+,33-/m1/s1
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 308n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50080461
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Cc1nc2C3Oc4c5c(C[C@H]6N(CC7CC7)CC[C@@]35[C@@]6(O)Cc2c(n1)-c1ccccc1)ccc4O
Show InChI InChI=1S/C29H29N3O3/c1-16-30-24(18-5-3-2-4-6-18)20-14-29(34)22-13-19-9-10-21(33)26-23(19)28(29,27(35-26)25(20)31-16)11-12-32(22)15-17-7-8-17/h2-6,9-10,17,22,27,33-34H,7-8,11-15H2,1H3/t22-,27?,28+,29-/m1/s1
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 325n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001193
PNG
(CHEMBL2112577)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(nc(nc21)-c1ccccc1)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C34H31N3O3/c38-25-14-13-23-17-26-34(39)18-24-28(21-7-3-1-4-8-21)35-32(22-9-5-2-6-10-22)36-29(24)31-33(34,27(23)30(25)40-31)15-16-37(26)19-20-11-12-20/h1-10,13-14,20,26,31,38-39H,11-12,15-19H2/t26-,31+,33+,34-/m1/s1
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 344n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001163
PNG
(CHEMBL2112570)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(ncnc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C28H27N3O3/c32-20-9-8-18-12-21-28(33)13-19-23(17-4-2-1-3-5-17)29-15-30-24(19)26-27(28,22(18)25(20)34-26)10-11-31(21)14-16-6-7-16/h1-5,8-9,15-16,21,26,32-33H,6-7,10-14H2/t21-,26+,27+,28-/m1/s1
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 348n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50080461
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Cc1nc2C3Oc4c5c(C[C@H]6N(CC7CC7)CC[C@@]35[C@@]6(O)Cc2c(n1)-c1ccccc1)ccc4O
Show InChI InChI=1S/C29H29N3O3/c1-16-30-24(18-5-3-2-4-6-18)20-14-29(34)22-13-19-9-10-21(33)26-23(19)28(29,27(35-26)25(20)31-16)11-12-32(22)15-17-7-8-17/h2-6,9-10,17,22,27,33-34H,7-8,11-15H2,1H3/t22-,27?,28+,29-/m1/s1
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 565n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001192
PNG
(CHEMBL2112568)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(cc(nc21)-c1ccccc1)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C35H32N2O3/c38-28-14-13-24-17-29-35(39)19-26-25(22-7-3-1-4-8-22)18-27(23-9-5-2-6-10-23)36-31(26)33-34(35,30(24)32(28)40-33)15-16-37(29)20-21-11-12-21/h1-10,13-14,18,21,29,33,38-39H,11-12,15-17,19-20H2/t29-,33+,34+,35-/m1/s1
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 652n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50080470
PNG
(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Show SMILES Cc1cc(-c2ccccc2)c2C[C@@]3(O)[C@H]4Cc5ccc(O)c6OC(c2n1)[C@]3(CCN4CC1CC1)c56
Show InChI InChI=1S/C30H30N2O3/c1-17-13-21(19-5-3-2-4-6-19)22-15-30(34)24-14-20-9-10-23(33)27-25(20)29(30,28(35-27)26(22)31-17)11-12-32(24)16-18-7-8-18/h2-6,9-10,13,18,24,28,33-34H,7-8,11-12,14-16H2,1H3/t24-,28?,29+,30-/m1/s1
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 677n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001193
PNG
(CHEMBL2112577)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(nc(nc21)-c1ccccc1)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C34H31N3O3/c38-25-14-13-23-17-26-34(39)18-24-28(21-7-3-1-4-8-21)35-32(22-9-5-2-6-10-22)36-29(24)31-33(34,27(23)30(25)40-31)15-16-37(26)19-20-11-12-20/h1-10,13-14,20,26,31,38-39H,11-12,15-19H2/t26-,31+,33+,34-/m1/s1
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 1.17E+3n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001194
PNG
(CHEMBL2112578)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(nc(Cc4ccccc4)nc21)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C35H33N3O3/c39-26-14-13-24-18-27-35(40)19-25-30(23-9-5-2-6-10-23)36-28(17-21-7-3-1-4-8-21)37-31(25)33-34(35,29(24)32(26)41-33)15-16-38(27)20-22-11-12-22/h1-10,13-14,22,27,33,39-40H,11-12,15-20H2/t27-,33+,34+,35-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
 1.27E+3n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001192
PNG
(CHEMBL2112568)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(cc(nc21)-c1ccccc1)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C35H32N2O3/c38-28-14-13-24-17-29-35(39)19-26-25(22-7-3-1-4-8-22)18-27(23-9-5-2-6-10-23)36-31(26)33-34(35,30(24)32(28)40-33)15-16-37(29)20-21-11-12-21/h1-10,13-14,18,21,29,33,38-39H,11-12,15-17,19-20H2/t29-,33+,34+,35-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
 2.12E+3n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001193
PNG
(CHEMBL2112577)
Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c(nc(nc21)-c1ccccc1)-c1ccccc1)ccc3O |THB:10:9:17:4.5.6|
Show InChI InChI=1S/C34H31N3O3/c38-25-14-13-23-17-26-34(39)18-24-28(21-7-3-1-4-8-21)35-32(22-9-5-2-6-10-22)36-29(24)31-33(34,27(23)30(25)40-31)15-16-37(26)19-20-11-12-20/h1-10,13-14,20,26,31,38-39H,11-12,15-19H2/t26-,31+,33+,34-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.54E+3n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes

J Med Chem 42: 3527-38 (1999)


Article DOI: 10.1021/jm990039i
BindingDB Entry DOI: 10.7270/Q2QR4XSQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%