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PubMed code 10579829

Compile data set for download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 2b


(Zea mays)		BDBM19130
PNG
((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)
KEGG

UniProtKB/TrEMBL

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n/an/a 3n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082666
PNG
(4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]b...)
Show SMILES CN(C)c1ccc(cc1)C(=O)NCCCCCC(=O)NO
Show InChI InChI=1S/C15H23N3O3/c1-18(2)13-9-7-12(8-10-13)15(20)16-11-5-3-4-6-14(19)17-21/h7-10,21H,3-6,11H2,1-2H3,(H,16,20)(H,17,19)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082665
PNG
(4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)...)
Show SMILES CN(C)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082660
PNG
(Biphenyl-4-carboxylic acid (5-hydroxycarbamoyl-pen...)
Show SMILES ONC(=O)CCCCCNC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H22N2O3/c22-18(21-24)9-5-2-6-14-20-19(23)17-12-10-16(11-13-17)15-7-3-1-4-8-15/h1,3-4,7-8,10-13,24H,2,5-6,9,14H2,(H,20,23)(H,21,22)
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n/an/a 100n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082663
PNG
(CHEMBL143802 | N-(5-Hydroxycarbamoyl-pentyl)-4-met...)
Show SMILES COc1ccc(cc1)C(=O)NCCCCCC(=O)NO
Show InChI InChI=1S/C14H20N2O4/c1-20-12-8-6-11(7-9-12)14(18)15-10-4-2-3-5-13(17)16-19/h6-9,19H,2-5,10H2,1H3,(H,15,18)(H,16,17)
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n/an/a 140n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082664
PNG
(4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide |...)
Show SMILES ONC(=O)CCCCCNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C13H17ClN2O3/c14-11-7-5-10(6-8-11)13(18)15-9-3-1-2-4-12(17)16-19/h5-8,19H,1-4,9H2,(H,15,18)(H,16,17)
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n/an/a 150n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082659
PNG
(4-(dimethylamino)-N-{4-[(hydroxyamino)carbonyl]ben...)
Show SMILES CN(C)c1ccc(cc1)C(=O)NCc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C17H19N3O3/c1-20(2)15-9-7-13(8-10-15)16(21)18-11-12-3-5-14(6-4-12)17(22)19-23/h3-10,23H,11H2,1-2H3,(H,18,21)(H,19,22)
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n/an/a 180n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082661
PNG
(CHEMBL139999 | N-(5-Hydroxycarbamoyl-pentyl)-4-nit...)
Show SMILES ONC(=O)CCCCCNC(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C13H17N3O5/c17-12(15-19)4-2-1-3-9-14-13(18)10-5-7-11(8-6-10)16(20)21/h5-8,19H,1-4,9H2,(H,14,18)(H,15,17)
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Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082657
PNG
(4-Dimethylamino-N-(7-hydroxycarbamoyl-heptyl)-benz...)
Show SMILES CN(C)c1ccc(cc1)C(=O)NCCCCCCCC(=O)NO
Show InChI InChI=1S/C17H27N3O3/c1-20(2)15-11-9-14(10-12-15)17(22)18-13-7-5-3-4-6-8-16(21)19-23/h9-12,23H,3-8,13H2,1-2H3,(H,18,22)(H,19,21)
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n/an/a 300n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082658
PNG
(CHEMBL143849 | N-(5-Hydroxycarbamoyl-pentyl)-benza...)
Show SMILES ONC(=O)CCCCCNC(=O)c1ccccc1
Show InChI InChI=1S/C13H18N2O3/c16-12(15-18)9-5-2-6-10-14-13(17)11-7-3-1-4-8-11/h1,3-4,7-8,18H,2,5-6,9-10H2,(H,14,17)(H,15,16)
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n/an/a 900n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50082662
PNG
(4-Dimethylamino-N-(4-hydroxycarbamoyl-butyl)-benza...)
Show SMILES CN(C)c1ccc(cc1)C(=O)NCCCCC(=O)NO
Show InChI InChI=1S/C14H21N3O3/c1-17(2)12-8-6-11(7-9-12)14(19)15-10-4-3-5-13(18)16-20/h6-9,20H,3-5,10H2,1-2H3,(H,15,19)(H,16,18)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
Inhibition of maize Histone deacetylase 2 (HD-2) activity

J Med Chem 42: 4669-79 (1999)


BindingDB Entry DOI: 10.7270/Q2PC31M7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%