BindingDB logo
myBDB logout

PubMed code 10639279

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084127
PNG
((4S,7S,13S)-13-[(2S,3R)-2-Amino-3-(4-hydroxy-2,6-d...)
Show SMILES C[C@@H]([C@H](N)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(O)=O)C(C)(C)SSC1(C)C)c1c(C)cc(O)cc1C
Show InChI InChI=1S/C33H45N5O7S2/c1-17-13-21(39)14-18(2)24(17)19(3)25(34)29(42)37-26-30(43)35-16-23(40)36-22(15-20-11-9-8-10-12-20)28(41)38-27(31(44)45)33(6,7)47-46-32(26,4)5/h8-14,19,22,25-27,39H,15-16,34H2,1-7H3,(H,35,43)(H,36,40)(H,37,42)(H,38,41)(H,44,45)/t19-,22+,25+,26+,27+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 5n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50068132
PNG
(3-[(4-Benzyl-piperazin-1-yl)-(4-tert-butyl-phenyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)CC1)c1cccc(O)c1
Show InChI InChI=1S/C28H34N2O/c1-28(2,3)25-14-12-23(13-15-25)27(24-10-7-11-26(31)20-24)30-18-16-29(17-19-30)21-22-8-5-4-6-9-22/h4-15,20,27,31H,16-19,21H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 8.40n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084135
PNG
(3-[((S)-4-Benzyl-2-methyl-piperazin-1-yl)-(4-tert-...)
Show SMILES C[C@H]1CN(Cc2ccccc2)CCN1C(c1ccc(cc1)C(C)(C)C)c1cccc(O)c1
Show InChI InChI=1S/C29H36N2O/c1-22-20-30(21-23-9-6-5-7-10-23)17-18-31(22)28(25-11-8-12-27(32)19-25)24-13-15-26(16-14-24)29(2,3)4/h5-16,19,22,28,32H,17-18,20-21H2,1-4H3/t22-,28?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 11n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084129
PNG
(3-[(1-Benzyl-piperidin-4-yl)-(4-tert-butyl-phenyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(C1CCN(Cc2ccccc2)CC1)c1cccc(O)c1
Show InChI InChI=1S/C29H35NO/c1-29(2,3)26-14-12-23(13-15-26)28(25-10-7-11-27(31)20-25)24-16-18-30(19-17-24)21-22-8-5-4-6-9-22/h4-15,20,24,28,31H,16-19,21H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 33n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084134
PNG
(3-[((R)-4-Benzyl-2-hydroxymethyl-piperazin-1-yl)-(...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1CO)c1cccc(O)c1
Show InChI InChI=1S/C29H36N2O2/c1-29(2,3)25-14-12-23(13-15-25)28(24-10-7-11-27(33)18-24)31-17-16-30(20-26(31)21-32)19-22-8-5-4-6-9-22/h4-15,18,26,28,32-33H,16-17,19-21H2,1-3H3/t26-,28?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 38n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084133
PNG
(3-[((R)-4-Benzyl-2-benzyloxymethyl-piperazin-1-yl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1COCc1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C36H42N2O2/c1-36(2,3)32-19-17-30(18-20-32)35(31-15-10-16-34(39)23-31)38-22-21-37(24-28-11-6-4-7-12-28)25-33(38)27-40-26-29-13-8-5-9-14-29/h4-20,23,33,35,39H,21-22,24-27H2,1-3H3/t33-,35?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 38n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(MOUSE)		BDBM50084135
PNG
(3-[((S)-4-Benzyl-2-methyl-piperazin-1-yl)-(4-tert-...)
Show SMILES C[C@H]1CN(Cc2ccccc2)CCN1C(c1ccc(cc1)C(C)(C)C)c1cccc(O)c1
Show InChI InChI=1S/C29H36N2O/c1-22-20-30(21-23-9-6-5-7-10-23)17-18-31(22)28(25-11-8-12-27(32)19-25)24-13-15-26(16-14-24)29(2,3)4/h5-16,19,22,28,32H,17-18,20-21H2,1-4H3/t22-,28?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 290n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Agonist activity of the compound was determined using electrically induced smooth muscle contraction of mouse vas deferens.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(MOUSE)		BDBM50084129
PNG
(3-[(1-Benzyl-piperidin-4-yl)-(4-tert-butyl-phenyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(C1CCN(Cc2ccccc2)CC1)c1cccc(O)c1
Show InChI InChI=1S/C29H35NO/c1-29(2,3)26-14-12-23(13-15-26)28(25-10-7-11-27(31)20-25)24-16-18-30(19-17-24)21-22-8-5-4-6-9-22/h4-15,20,24,28,31H,16-19,21H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 390n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Agonist activity of the compound was determined using electrically induced smooth muscle contraction of mouse vas deferens.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(MOUSE)		BDBM50084134
PNG
(3-[((R)-4-Benzyl-2-hydroxymethyl-piperazin-1-yl)-(...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1CO)c1cccc(O)c1
Show InChI InChI=1S/C29H36N2O2/c1-29(2,3)25-14-12-23(13-15-25)28(24-10-7-11-27(33)18-24)31-17-16-30(20-26(31)21-32)19-22-8-5-4-6-9-22/h4-15,18,26,28,32-33H,16-17,19-21H2,1-3H3/t26-,28?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.26E+3n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Agonist activity of the compound was determined using electrically induced smooth muscle contraction of mouse vas deferens.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084135
PNG
(3-[((S)-4-Benzyl-2-methyl-piperazin-1-yl)-(4-tert-...)
Show SMILES C[C@H]1CN(Cc2ccccc2)CCN1C(c1ccc(cc1)C(C)(C)C)c1cccc(O)c1
Show InChI InChI=1S/C29H36N2O/c1-22-20-30(21-23-9-6-5-7-10-23)17-18-31(22)28(25-11-8-12-27(32)19-25)24-13-15-26(16-14-24)29(2,3)4/h5-16,19,22,28,32H,17-18,20-21H2,1-4H3/t22-,28?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.30E+3n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084129
PNG
(3-[(1-Benzyl-piperidin-4-yl)-(4-tert-butyl-phenyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(C1CCN(Cc2ccccc2)CC1)c1cccc(O)c1
Show InChI InChI=1S/C29H35NO/c1-29(2,3)26-14-12-23(13-15-26)28(25-10-7-11-27(31)20-25)24-16-18-30(19-17-24)21-22-8-5-4-6-9-22/h4-15,20,24,28,31H,16-19,21H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084127
PNG
((4S,7S,13S)-13-[(2S,3R)-2-Amino-3-(4-hydroxy-2,6-d...)
Show SMILES C[C@@H]([C@H](N)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(O)=O)C(C)(C)SSC1(C)C)c1c(C)cc(O)cc1C
Show InChI InChI=1S/C33H45N5O7S2/c1-17-13-21(39)14-18(2)24(17)19(3)25(34)29(42)37-26-30(43)35-16-23(40)36-22(15-20-11-9-8-10-12-20)28(41)38-27(31(44)45)33(6,7)47-46-32(26,4)5/h8-14,19,22,25-27,39H,15-16,34H2,1-7H3,(H,35,43)(H,36,40)(H,37,42)(H,38,41)(H,44,45)/t19-,22+,25+,26+,27+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084134
PNG
(3-[((R)-4-Benzyl-2-hydroxymethyl-piperazin-1-yl)-(...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1CO)c1cccc(O)c1
Show InChI InChI=1S/C29H36N2O2/c1-29(2,3)25-14-12-23(13-15-25)28(24-10-7-11-27(33)18-24)31-17-16-30(20-26(31)21-32)19-22-8-5-4-6-9-22/h4-15,18,26,28,32-33H,16-17,19-21H2,1-3H3/t26-,28?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 7.98E+3n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084131
PNG
(3-[(4-tert-Butyl-phenyl)-((S)-2,4-dibenzyl-piperaz...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1Cc1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C35H40N2O/c1-35(2,3)31-19-17-29(18-20-31)34(30-15-10-16-33(38)24-30)37-22-21-36(25-28-13-8-5-9-14-28)26-32(37)23-27-11-6-4-7-12-27/h4-20,24,32,34,38H,21-23,25-26H2,1-3H3/t32-,34?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084128
PNG
(3-[(4-Benzyl-piperidin-1-yl)-(4-tert-butyl-phenyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCC(Cc2ccccc2)CC1)c1cccc(O)c1
Show InChI InChI=1S/C29H35NO/c1-29(2,3)26-14-12-24(13-15-26)28(25-10-7-11-27(31)21-25)30-18-16-23(17-19-30)20-22-8-5-4-6-9-22/h4-15,21,23,28,31H,16-20H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.26E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50084129
PNG
(3-[(1-Benzyl-piperidin-4-yl)-(4-tert-butyl-phenyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(C1CCN(Cc2ccccc2)CC1)c1cccc(O)c1
Show InChI InChI=1S/C29H35NO/c1-29(2,3)26-14-12-23(13-15-26)28(25-10-7-11-27(31)20-25)24-16-18-30(19-17-24)21-22-8-5-4-6-9-22/h4-15,20,24,28,31H,16-19,21H2,1-3H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.56E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Agonist activity of the compound was determined using strips of guinea pig ileum longitudinal muscle myenteric plexus.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50068132
PNG
(3-[(4-Benzyl-piperazin-1-yl)-(4-tert-butyl-phenyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)CC1)c1cccc(O)c1
Show InChI InChI=1S/C28H34N2O/c1-28(2,3)25-14-12-23(13-15-25)27(24-10-7-11-26(31)20-24)30-18-16-29(17-19-30)21-22-8-5-4-6-9-22/h4-15,20,27,31H,16-19,21H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084131
PNG
(3-[(4-tert-Butyl-phenyl)-((S)-2,4-dibenzyl-piperaz...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1Cc1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C35H40N2O/c1-35(2,3)31-19-17-29(18-20-31)34(30-15-10-16-33(38)24-30)37-22-21-36(25-28-13-8-5-9-14-28)26-32(37)23-27-11-6-4-7-12-27/h4-20,24,32,34,38H,21-23,25-26H2,1-3H3/t32-,34?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 2.13E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-deltorphin binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084128
PNG
(3-[(4-Benzyl-piperidin-1-yl)-(4-tert-butyl-phenyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCC(Cc2ccccc2)CC1)c1cccc(O)c1
Show InChI InChI=1S/C29H35NO/c1-29(2,3)26-14-12-24(13-15-26)28(25-10-7-11-27(31)21-25)30-18-16-23(17-19-30)20-22-8-5-4-6-9-22/h4-15,21,23,28,31H,16-20H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.29E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084133
PNG
(3-[((R)-4-Benzyl-2-benzyloxymethyl-piperazin-1-yl)...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1COCc1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C36H42N2O2/c1-36(2,3)32-19-17-30(18-20-32)35(31-15-10-16-34(39)23-31)38-22-21-37(24-28-11-6-4-7-12-28)25-33(38)27-40-26-29-13-8-5-9-14-29/h4-20,23,33,35,39H,21-22,24-27H2,1-3H3/t33-,35?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084132
PNG
(3,5-Dibenzyl-[1,3,5]thiadiazinane-2-thione | CHEMB...)
Show SMILES S=C1SCN(Cc2ccccc2)CN1Cc1ccccc1
Show InChI InChI=1S/C17H18N2S2/c20-17-19(12-16-9-5-2-6-10-16)13-18(14-21-17)11-15-7-3-1-4-8-15/h1-10H,11-14H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 2.79E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084132
PNG
(3,5-Dibenzyl-[1,3,5]thiadiazinane-2-thione | CHEMB...)
Show SMILES S=C1SCN(Cc2ccccc2)CN1Cc1ccccc1
Show InChI InChI=1S/C17H18N2S2/c20-17-19(12-16-9-5-2-6-10-16)13-18(14-21-17)11-15-7-3-1-4-8-15/h1-10H,11-14H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 2.86E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]- [p-Cl-Phe4]DPDPE binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084130
PNG
(5-Benzyl-6-thioxo-[1,3,5]thiadiazinane-3-carboxyli...)
Show SMILES Oc1ccc(COC(=O)N2CSC(=S)N(Cc3ccccc3)C2)cc1
Show InChI InChI=1S/C18H18N2O3S2/c21-16-8-6-15(7-9-16)11-23-17(22)20-12-19(18(24)25-13-20)10-14-4-2-1-3-5-14/h1-9,21H,10-13H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 3.83E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084130
PNG
(5-Benzyl-6-thioxo-[1,3,5]thiadiazinane-3-carboxyli...)
Show SMILES Oc1ccc(COC(=O)N2CSC(=S)N(Cc3ccccc3)C2)cc1
Show InChI InChI=1S/C18H18N2O3S2/c21-16-8-6-15(7-9-16)11-23-17(22)20-12-19(18(24)25-13-20)10-14-4-2-1-3-5-14/h1-9,21H,10-13H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 4.47E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]- [p-Cl-Phe4]DPDPE binding to Opioid receptor delta 1 using rat brain membranes.

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084131
PNG
(3-[(4-tert-Butyl-phenyl)-((S)-2,4-dibenzyl-piperaz...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1Cc1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C35H40N2O/c1-35(2,3)31-19-17-29(18-20-31)34(30-15-10-16-33(38)24-30)37-22-21-36(25-28-13-8-5-9-14-28)26-32(37)23-27-11-6-4-7-12-27/h4-20,24,32,34,38H,21-23,25-26H2,1-3H3/t32-,34?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 4.63E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50084131
PNG
(3-[(4-tert-Butyl-phenyl)-((S)-2,4-dibenzyl-piperaz...)
Show SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1Cc1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C35H40N2O/c1-35(2,3)31-19-17-29(18-20-31)34(30-15-10-16-33(38)24-30)37-22-21-36(25-28-13-8-5-9-14-28)26-32(37)23-27-11-6-4-7-12-27/h4-20,24,32,34,38H,21-23,25-26H2,1-3H3/t32-,34?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>8.00E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes

J Med Chem 42: 5359-68 (2000)


BindingDB Entry DOI: 10.7270/Q23777XM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%