Found 18 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085576
(5-(4-{2-[1-(4-Pyridin-3-yl-phenyl)-eth-(E)-ylidene...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C25H23N3O4S/c1-17(19-6-8-20(9-7-19)21-3-2-12-26-16-21)28-32-14-13-31-22-10-4-18(5-11-22)15-23-24(29)27-25(30)33-23/h2-12,16,29H,13-15H2,1H3,(H,27,30)/b28-17+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085578
(5-(4-{2-[1-Biphenyl-4-yl-but-(E)-ylideneaminooxy]-...)Show SMILES CCC\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C28H28N2O4S/c1-2-6-25(23-13-11-22(12-14-23)21-7-4-3-5-8-21)30-34-18-17-33-24-15-9-20(10-16-24)19-26-27(31)29-28(32)35-26/h3-5,7-16,31H,2,6,17-19H2,1H3,(H,29,32)/b30-25+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085581
(5-(4-{2-[1-(4-Pyridin-2-yl-phenyl)-eth-(E)-ylidene...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(cc1)-c1ccccn1 Show InChI InChI=1S/C25H23N3O4S/c1-17(19-7-9-20(10-8-19)22-4-2-3-13-26-22)28-32-15-14-31-21-11-5-18(6-12-21)16-23-24(29)27-25(30)33-23/h2-13,29H,14-16H2,1H3,(H,27,30)/b28-17+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 640 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM28681
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
PubMed
| n/a | n/a | n/a | n/a | 730 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085577
(5-(4-{2-[1-Biphenyl-4-yl-prop-(E)-ylideneaminooxy]...)Show SMILES CC\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C27H26N2O4S/c1-2-24(22-12-10-21(11-13-22)20-6-4-3-5-7-20)29-33-17-16-32-23-14-8-19(9-15-23)18-25-26(30)28-27(31)34-25/h3-15,30H,2,16-18H2,1H3,(H,28,31)/b29-24+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085583
(5-(4-{2-[1-Phenyl-eth-(E)-ylideneaminooxy]-ethoxy}...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccc1 Show InChI InChI=1S/C20H20N2O4S/c1-14(16-5-3-2-4-6-16)22-26-12-11-25-17-9-7-15(8-10-17)13-18-19(23)21-20(24)27-18/h2-10,23H,11-13H2,1H3,(H,21,24)/b22-14+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085585
(5-(4-{2-[1-Pyridin-4-yl-eth-(E)-ylideneaminooxy]-e...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccncc1 Show InChI InChI=1S/C19H19N3O4S/c1-13(15-6-8-20-9-7-15)22-26-11-10-25-16-4-2-14(3-5-16)12-17-18(23)21-19(24)27-17/h2-9,23H,10-12H2,1H3,(H,21,24)/b22-13+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50049240
((+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)m...)Show InChI InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,22H,2,9-11H2,1H3,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085584
(5-(4-{2-[1-(6-Phenyl-pyridin-3-yl)-eth-(E)-ylidene...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(nc1)-c1ccccc1 Show InChI InChI=1S/C25H23N3O4S/c1-17(20-9-12-22(26-16-20)19-5-3-2-4-6-19)28-32-14-13-31-21-10-7-18(8-11-21)15-23-24(29)27-25(30)33-23/h2-12,16,29H,13-15H2,1H3,(H,27,30)/b28-17+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 190 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085580
(5-(4-{3-[1-Biphenyl-4-yl-eth-(E)-ylideneaminooxy]-...)Show SMILES C\C(=N/OCCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C27H26N2O4S/c1-19(21-10-12-23(13-11-21)22-6-3-2-4-7-22)29-33-17-5-16-32-24-14-8-20(9-15-24)18-25-26(30)28-27(31)34-25/h2-4,6-15,30H,5,16-18H2,1H3,(H,28,31)/b29-19+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085582
(5-(4-{2-[1-Biphenyl-2-yl-eth-(E)-ylideneaminooxy]-...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccc1-c1ccccc1 Show InChI InChI=1S/C26H24N2O4S/c1-18(22-9-5-6-10-23(22)20-7-3-2-4-8-20)28-32-16-15-31-21-13-11-19(12-14-21)17-24-25(29)27-26(30)33-24/h2-14,29H,15-17H2,1H3,(H,27,30)/b28-18+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085587
(5-(4-{2-[1-Biphenyl-4-yl-eth-(E)-ylideneaminooxy]-...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C26H24N2O4S/c1-18(20-9-11-22(12-10-20)21-5-3-2-4-6-21)28-32-16-15-31-23-13-7-19(8-14-23)17-24-25(29)27-26(30)33-24/h2-14,29H,15-17H2,1H3,(H,27,30)/b28-18+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085575
(5-(4-{2-[1-Biphenyl-3-yl-eth-(E)-ylideneaminooxy]-...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C26H24N2O4S/c1-18(21-8-5-9-22(17-21)20-6-3-2-4-7-20)28-32-15-14-31-23-12-10-19(11-13-23)16-24-25(29)27-26(30)33-24/h2-13,17,29H,14-16H2,1H3,(H,27,30)/b28-18+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 330 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085588
(5-(4-{2-[1-Pyridin-3-yl-eth-(E)-ylideneaminooxy]-e...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1cccnc1 Show InChI InChI=1S/C19H19N3O4S/c1-13(15-3-2-8-20-12-15)22-26-10-9-25-16-6-4-14(5-7-16)11-17-18(23)21-19(24)27-17/h2-8,12,23H,9-11H2,1H3,(H,21,24)/b22-13+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085589
(Biphenyl-4-carbaldehyde O-{2-[4-(2,4-dioxo-thiazol...)Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(OCCO\N=C\c2ccc(cc2)-c2ccccc2)cc1 Show InChI InChI=1S/C25H22N2O4S/c28-24-23(32-25(29)27-24)16-18-8-12-22(13-9-18)30-14-15-31-26-17-19-6-10-21(11-7-19)20-4-2-1-3-5-20/h1-13,17,28H,14-16H2,(H,27,29)/b26-17+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085590
(5-(4-{2-[1-Pyridin-2-yl-eth-(E)-ylideneaminooxy]-e...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccn1 Show InChI InChI=1S/C19H19N3O4S/c1-13(16-4-2-3-9-20-16)22-26-11-10-25-15-7-5-14(6-8-15)12-17-18(23)21-19(24)27-17/h2-9,23H,10-12H2,1H3,(H,21,24)/b22-13+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085586
(5-(4-{2-[1-(5-Phenyl-pyridin-2-yl)-eth-(E)-ylidene...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(cn1)-c1ccccc1 Show InChI InChI=1S/C25H23N3O4S/c1-17(22-12-9-20(16-26-22)19-5-3-2-4-6-19)28-32-14-13-31-21-10-7-18(8-11-21)15-23-24(29)27-25(30)33-23/h2-12,16,29H,13-15H2,1H3,(H,27,30)/b28-17+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085579
(5-(4-{2-[1-(4-Pyridin-4-yl-phenyl)-eth-(E)-ylidene...)Show SMILES C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(cc1)-c1ccncc1 Show InChI InChI=1S/C25H23N3O4S/c1-17(19-4-6-20(7-5-19)21-10-12-26-13-11-21)28-32-15-14-31-22-8-2-18(3-9-22)16-23-24(29)27-25(30)33-23/h2-13,29H,14-16H2,1H3,(H,27,30)/b28-17+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells. |
Bioorg Med Chem Lett 10: 373-5 (2000)
BindingDB Entry DOI: 10.7270/Q22B8ZJG |
More data for this
Ligand-Target Pair | |
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