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PubMed code 10743949

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086666
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3
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 1.30n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086666
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3
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 2.70n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086666
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3
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 5.30n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086668
PNG
(7-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-18-21(12-17)30-15-22(27)23-18/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
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 8.30n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218566
PNG
(CHEMBL140477)
Show SMILES COc1ccccc1N1CCN(CCCOc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-19-8-3-2-7-18(19)25-13-11-24(12-14-25)10-5-15-28-20-9-4-6-17-22(20)29-16-21(26)23-17/h2-4,6-9H,5,10-16H2,1H3,(H,23,26)
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 14n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218562
PNG
(CHEMBL141194)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-20-6-3-2-5-19(20)25-12-10-24(11-13-25)9-4-14-28-17-7-8-21-18(15-17)23-22(26)16-29-21/h2-3,5-8,15H,4,9-14,16H2,1H3,(H,23,26)
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 15n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086677
PNG
(6-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-21-18(12-17)23-22(27)15-30-21/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
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 16n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086665
PNG
(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
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 20n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086673
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4H-benzo[1...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CSc12
Show InChI InChI=1S/C15H22N2O3S/c1-15(2,3)16-7-10(18)8-20-12-6-4-5-11-14(12)21-9-13(19)17-11/h4-6,10,16,18H,7-9H2,1-3H3,(H,17,19)
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 20n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218565
PNG
(CHEMBL143288)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-20-6-3-2-5-19(20)25-12-10-24(11-13-25)9-4-14-28-17-7-8-18-21(15-17)29-16-22(26)23-18/h2-3,5-8,15H,4,9-14,16H2,1H3,(H,23,26)
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 23n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086673
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4H-benzo[1...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CSc12
Show InChI InChI=1S/C15H22N2O3S/c1-15(2,3)16-7-10(18)8-20-12-6-4-5-11-14(12)21-9-13(19)17-11/h4-6,10,16,18H,7-9H2,1-3H3,(H,17,19)
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 23n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218563
PNG
(CHEMBL341723)
Show SMILES COc1ccccc1N1CCN(CCOc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-19-5-3-2-4-18(19)24-10-8-23(9-11-24)12-13-27-16-6-7-17-20(14-16)28-15-21(25)22-17/h2-7,14H,8-13,15H2,1H3,(H,22,25)
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 23n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086670
PNG
(8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-19-7-3-2-6-18(19)25-11-9-24(10-12-25)13-16(26)14-29-20-8-4-5-17-22(20)30-15-21(27)23-17/h2-8,16,26H,9-15H2,1H3,(H,23,27)
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 27n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218563
PNG
(CHEMBL341723)
Show SMILES COc1ccccc1N1CCN(CCOc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-19-5-3-2-4-18(19)24-10-8-23(9-11-24)12-13-27-16-6-7-17-20(14-16)28-15-21(25)22-17/h2-7,14H,8-13,15H2,1H3,(H,22,25)
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 32n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086662
PNG
(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3ccccc23)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-27-20-9-4-2-7-18(20)24-15-13-23(14-16-24)11-6-12-25-19-8-3-5-10-21(19)28-17-22(25)26/h2-5,7-10H,6,11-17H2,1H3
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 38n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50773
PNG
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
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 39n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086679
PNG
(8-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-4-6-16(7-5-15)25-10-8-24(9-11-25)12-17(26)13-28-19-3-1-2-18-21(19)29-14-20(27)23-18/h1-7,17,26H,8-14H2,(H,23,27)
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 60n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218567
PNG
(CHEMBL142859)
Show SMILES COc1ccccc1N1CCN(CCOc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-18-7-3-2-6-17(18)24-11-9-23(10-12-24)13-14-27-19-8-4-5-16-21(19)28-15-20(25)22-16/h2-8H,9-15H2,1H3,(H,22,25)
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 73n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086670
PNG
(8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-19-7-3-2-6-18(19)25-11-9-24(10-12-25)13-16(26)14-29-20-8-4-5-17-22(20)30-15-21(27)23-17/h2-8,16,26H,9-15H2,1H3,(H,23,27)
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 88n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086663
PNG
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
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 90n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218566
PNG
(CHEMBL140477)
Show SMILES COc1ccccc1N1CCN(CCCOc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-19-8-3-2-7-18(19)25-13-11-24(12-14-25)10-5-15-28-20-9-4-6-17-22(20)29-16-21(26)23-17/h2-4,6-9H,5,10-16H2,1H3,(H,23,26)
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 99n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086660
PNG
(6-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-20-19(11-18)24-21(28)14-31-20/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
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 100n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086670
PNG
(8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-19-7-3-2-6-18(19)25-11-9-24(10-12-25)13-16(26)14-29-20-8-4-5-17-22(20)30-15-21(27)23-17/h2-8,16,26H,9-15H2,1H3,(H,23,27)
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 330n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218562
PNG
(CHEMBL141194)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-20-6-3-2-5-19(20)25-12-10-24(11-13-25)9-4-14-28-17-7-8-21-18(15-17)23-22(26)16-29-21/h2-3,5-8,15H,4,9-14,16H2,1H3,(H,23,26)
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 370n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086662
PNG
(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3ccccc23)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-27-20-9-4-2-7-18(20)24-15-13-23(14-16-24)11-6-12-25-19-8-3-5-10-21(19)28-17-22(25)26/h2-5,7-10H,6,11-17H2,1H3
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 440n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086666
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3
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 530n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218564
PNG
(CHEMBL143923)
Show SMILES COc1ccccc1N1CCN(CCOc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-19-5-3-2-4-18(19)24-10-8-23(9-11-24)12-13-27-16-6-7-20-17(14-16)22-21(25)15-28-20/h2-7,14H,8-13,15H2,1H3,(H,22,25)
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 540n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086672
PNG
(7-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-16-18(10-15)29-13-19(25)21-16)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086678
PNG
(7-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-19-20(11-18)31-14-21(28)24-19/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
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>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086677
PNG
(6-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-21-18(12-17)23-22(27)15-30-21/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
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Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086673
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4H-benzo[1...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CSc12
Show InChI InChI=1S/C15H22N2O3S/c1-15(2,3)16-7-10(18)8-20-12-6-4-5-11-14(12)21-9-13(19)17-11/h4-6,10,16,18H,7-9H2,1-3H3,(H,17,19)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-prazosin binding in rat brain; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086663
PNG
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086663
PNG
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086674
PNG
(6-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-18-16(10-15)21-19(25)13-29-18)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-prazosin binding in rat brain; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086675
PNG
(8-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-6-4-15(5-7-16)22(29)26-10-8-25(9-11-26)12-17(27)13-30-19-3-1-2-18-21(19)31-14-20(28)24-18/h1-7,17,27H,8-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086665
PNG
(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086679
PNG
(8-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-4-6-16(7-5-15)25-10-8-24(9-11-25)12-17(26)13-28-19-3-1-2-18-21(19)29-14-20(27)23-18/h1-7,17,26H,8-14H2,(H,23,27)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50773
PNG
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
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 1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086675
PNG
(8-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-6-4-15(5-7-16)22(29)26-10-8-25(9-11-26)12-17(27)13-30-19-3-1-2-18-21(19)31-14-20(28)24-18/h1-7,17,27H,8-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086662
PNG
(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3ccccc23)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-27-20-9-4-2-7-18(20)24-15-13-23(14-16-24)11-6-12-25-19-8-3-5-10-21(19)28-17-22(25)26/h2-5,7-10H,6,11-17H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086675
PNG
(8-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-6-4-15(5-7-16)22(29)26-10-8-25(9-11-26)12-17(27)13-30-19-3-1-2-18-21(19)31-14-20(28)24-18/h1-7,17,27H,8-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086675
PNG
(8-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-6-4-15(5-7-16)22(29)26-10-8-25(9-11-26)12-17(27)13-30-19-3-1-2-18-21(19)31-14-20(28)24-18/h1-7,17,27H,8-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-prazosin binding in rat brain; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086660
PNG
(6-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-20-19(11-18)24-21(28)14-31-20/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-prazosin binding in rat brain; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086668
PNG
(7-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-18-21(12-17)30-15-22(27)23-18/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086668
PNG
(7-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-18-21(12-17)30-15-22(27)23-18/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
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Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086678
PNG
(7-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-19-20(11-18)31-14-21(28)24-19/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-prazosin binding in rat brain; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086678
PNG
(7-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-19-20(11-18)31-14-21(28)24-19/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086672
PNG
(7-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-16-18(10-15)29-13-19(25)21-16)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-prazosin binding in rat brain; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50773
PNG
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
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Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086660
PNG
(6-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-20-19(11-18)24-21(28)14-31-20/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086674
PNG
(6-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-18-16(10-15)21-19(25)13-29-18)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086673
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4H-benzo[1...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CSc12
Show InChI InChI=1S/C15H22N2O3S/c1-15(2,3)16-7-10(18)8-20-12-6-4-5-11-14(12)21-9-13(19)17-11/h4-6,10,16,18H,7-9H2,1-3H3,(H,17,19)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086660
PNG
(6-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-20-19(11-18)24-21(28)14-31-20/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086662
PNG
(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3ccccc23)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-27-20-9-4-2-7-18(20)24-15-13-23(14-16-24)11-6-12-25-19-8-3-5-10-21(19)28-17-22(25)26/h2-5,7-10H,6,11-17H2,1H3
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086678
PNG
(7-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-19-20(11-18)31-14-21(28)24-19/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086670
PNG
(8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-19-7-3-2-6-18(19)25-11-9-24(10-12-25)13-16(26)14-29-20-8-4-5-17-22(20)30-15-21(27)23-17/h2-8,16,26H,9-15H2,1H3,(H,23,27)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086664
PNG
(8-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-16-4-1-3-15-19(16)29-13-18(25)21-15)11-22-6-8-23(9-7-22)20(26)17-5-2-10-27-17/h1-5,10,14,24H,6-9,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086674
PNG
(6-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-18-16(10-15)21-19(25)13-29-18)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086674
PNG
(6-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-18-16(10-15)21-19(25)13-29-18)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086664
PNG
(8-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-16-4-1-3-15-19(16)29-13-18(25)21-15)11-22-6-8-23(9-7-22)20(26)17-5-2-10-27-17/h1-5,10,14,24H,6-9,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086672
PNG
(7-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-16-18(10-15)29-13-19(25)21-16)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086664
PNG
(8-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-16-4-1-3-15-19(16)29-13-18(25)21-15)11-22-6-8-23(9-7-22)20(26)17-5-2-10-27-17/h1-5,10,14,24H,6-9,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086672
PNG
(7-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-16-18(10-15)29-13-19(25)21-16)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
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Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086679
PNG
(8-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-4-6-16(7-5-15)25-10-8-24(9-11-25)12-17(26)13-28-19-3-1-2-18-21(19)29-14-20(27)23-18/h1-7,17,26H,8-14H2,(H,23,27)
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 1.50E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50773
PNG
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
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 1.60E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218565
PNG
(CHEMBL143288)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-20-6-3-2-5-19(20)25-12-10-24(11-13-25)9-4-14-28-17-7-8-18-21(15-17)29-16-22(26)23-18/h2-3,5-8,15H,4,9-14,16H2,1H3,(H,23,26)
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 1.71E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218567
PNG
(CHEMBL142859)
Show SMILES COc1ccccc1N1CCN(CCOc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-18-7-3-2-6-17(18)24-11-9-23(10-12-24)13-14-27-19-8-4-5-16-21(19)28-15-20(25)22-16/h2-8H,9-15H2,1H3,(H,22,25)
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 2.30E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086664
PNG
(8-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-16-4-1-3-15-19(16)29-13-18(25)21-15)11-22-6-8-23(9-7-22)20(26)17-5-2-10-27-17/h1-5,10,14,24H,6-9,11-13H2,(H,21,25)
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 2.40E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086668
PNG
(7-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-18-21(12-17)30-15-22(27)23-18/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
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 3.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086677
PNG
(6-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-21-18(12-17)23-22(27)15-30-21/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
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 3.30E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086677
PNG
(6-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-21-18(12-17)23-22(27)15-30-21/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
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 4.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218564
PNG
(CHEMBL143923)
Show SMILES COc1ccccc1N1CCN(CCOc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-19-5-3-2-4-18(19)24-10-8-23(9-11-24)12-13-27-16-6-7-20-17(14-16)22-21(25)15-28-20/h2-7,14H,8-13,15H2,1H3,(H,22,25)
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 4.60E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086665
PNG
(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
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 4.60E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086665
PNG
(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
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 4.80E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086663
PNG
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
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 5.30E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086679
PNG
(8-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-4-6-16(7-5-15)25-10-8-24(9-11-25)12-17(26)13-28-19-3-1-2-18-21(19)29-14-20(27)23-18/h1-7,17,26H,8-14H2,(H,23,27)
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 6.70E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%