Affinity Data by PubMed id=11052796

PubMed code 11052796

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	2.95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 1 with guinea pig membranes and [3H]- pentazocine as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	46.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 2 with rat liver membranes and [3H]- DTG as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092739 (CHEMBL126131 \| N-(2-Diethylamino-ethyl)-5-iodo-2-m...) Show SMILES CCN(CC)CCNC(=O)c1cc(I)ccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	92	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 1 with guinea pig membranes and [3H]- pentazocine as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092741 (CHEMBL338468 \| N-(2-Diethylamino-ethyl)-3-iodo-4-m...) Show SMILES CCN(CC)CCNC(=O)c1ccc(OC)c(I)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	249	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 1 with guinea pig membranes and [3H]- pentazocine as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092738 (4-Amino-5-bromo-N-(2-diethylamino-ethyl)-3-iodo-2-...) Show SMILES CCN(CC)CCNC(=O)c1cc(Br)c(N)c(I)c1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	278	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 1 with guinea pig membranes and [3H]- pentazocine as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092737 (CHEMBL339009 \| N-(2-Diethylamino-ethyl)-2-iodo-5-m...) Show SMILES CCN(CC)CCNC(=O)c1cc(OC)ccc1I Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	347	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 2 with rat liver membranes and [3H]- DTG as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092737 (CHEMBL339009 \| N-(2-Diethylamino-ethyl)-2-iodo-5-m...) Show SMILES CCN(CC)CCNC(=O)c1cc(OC)ccc1I Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	455	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 1 with guinea pig membranes and [3H]- pentazocine as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092736 (4-Amino-N-(2-diethylamino-ethyl)-5-iodo-2-methoxy-...) Show SMILES CCN(CC)CCNC(=O)c1cc(I)c(N)cc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	484	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 1 with guinea pig membranes and [3H]- pentazocine as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092739 (CHEMBL126131 \| N-(2-Diethylamino-ethyl)-5-iodo-2-m...) Show SMILES CCN(CC)CCNC(=O)c1cc(I)ccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 2 with rat liver membranes and [3H]- DTG as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092738 (4-Amino-5-bromo-N-(2-diethylamino-ethyl)-3-iodo-2-...) Show SMILES CCN(CC)CCNC(=O)c1cc(Br)c(N)c(I)c1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	2.35E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 2 with rat liver membranes and [3H]- DTG as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092742 (4-Acetylamino-N-(2-diethylamino-ethyl)-3-iodo-benz...) Show SMILES CCN(CC)CCNC(=O)c1ccc(NC(C)=O)c(I)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	4.65E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 1 with guinea pig membranes and [3H]- pentazocine as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092740 (4-Acetylamino-N-(2-diethylamino-ethyl)-5-iodo-2-me...) Show SMILES CCN(CC)CCNC(=O)c1cc(I)c(NC(C)=O)cc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.19E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 1 with guinea pig membranes and [3H]- pentazocine as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092741 (CHEMBL338468 \| N-(2-Diethylamino-ethyl)-3-iodo-4-m...) Show SMILES CCN(CC)CCNC(=O)c1ccc(OC)c(I)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	6.52E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 2 with rat liver membranes and [3H]- DTG as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092736 (4-Amino-N-(2-diethylamino-ethyl)-5-iodo-2-methoxy-...) Show SMILES CCN(CC)CCNC(=O)c1cc(I)c(N)cc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 2 with rat liver membranes and [3H]- DTG as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092740 (4-Acetylamino-N-(2-diethylamino-ethyl)-5-iodo-2-me...) Show SMILES CCN(CC)CCNC(=O)c1cc(I)c(NC(C)=O)cc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.15E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 2 with rat liver membranes and [3H]- DTG as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50092742 (4-Acetylamino-N-(2-diethylamino-ethyl)-3-iodo-benz...) Show SMILES CCN(CC)CCNC(=O)c1ccc(NC(C)=O)c(I)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	1.48E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Heidelberg Curated by ChEMBL					Assay Description Binding affinity was measured on Sigma receptor type 2 with rat liver membranes and [3H]- DTG as ligand.				J Med Chem 43: 3913-22 (2000) BindingDB Entry DOI: 10.7270/Q2G44PJ9
University of Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%