Found 4 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50105862
(CHEMBL410632 | pGlu-His-Trp-Ser-Tyr-D-Lys(2-(hydro...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNOC(=O)c1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NOC(=O)C1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O Show InChI InChI=1S/C74H90N18O21/c1-36(2)23-50(65(103)86-48(12-7-20-79-74(76)77)71(109)92-22-8-13-55(92)70(108)81-33-58(75)98)87-64(102)47(11-5-6-21-83-112-72(110)38-25-44-60(56(96)27-38)63(101)61-45(62(44)100)29-42(95)30-57(61)97)85-66(104)51(24-37-14-16-41(94)17-15-37)88-69(107)54(34-93)90-67(105)52(26-39-31-80-46-10-4-3-9-43(39)46)89-68(106)53(28-40-32-78-35-82-40)91-113-73(111)49-18-19-59(99)84-49/h3-4,9-10,14-17,25,27,29-32,35-36,47-55,80,83,91,93-97H,5-8,11-13,18-24,26,28,33-34H2,1-2H3,(H2,75,98)(H,78,82)(H,81,108)(H,84,99)(H,85,104)(H,86,103)(H,87,102)(H,88,107)(H,89,106)(H,90,105)(H4,76,77,79)/t47-,48-,49?,50-,51-,52-,53-,54-,55-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.00200 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description
Evaluated for gonadotropin-releasing hormone receptor binding by displacing the 50% of the bound tracer [125I]-[D-Lys6]-GnRH radioligand in rat pitui... |
J Med Chem 44: 3645-52 (2001)
BindingDB Entry DOI: 10.7270/Q2W66K2Z |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50105860
(CHEMBL385043 | pGlu-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O Show InChI InChI=1S/C59H84N18O13/c1-32(2)23-42(52(84)71-41(12-7-21-65-59(62)63)58(90)77-22-8-13-47(77)57(89)67-29-48(61)80)72-50(82)39(11-5-6-20-60)70-53(85)43(24-33-14-16-36(79)17-15-33)73-56(88)46(30-78)76-54(86)44(25-34-27-66-38-10-4-3-9-37(34)38)74-55(87)45(26-35-28-64-31-68-35)75-51(83)40-18-19-49(81)69-40/h3-4,9-10,14-17,27-28,31-32,39-47,66,78-79H,5-8,11-13,18-26,29-30,60H2,1-2H3,(H2,61,80)(H,64,68)(H,67,89)(H,69,81)(H,70,85)(H,71,84)(H,72,82)(H,73,88)(H,74,87)(H,75,83)(H,76,86)(H4,62,63,65)/t39-,40?,41+,42+,43+,44+,45+,46+,47-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description
Evaluated for gonadotropin-releasing hormone receptor binding by displacing the 50% of the bound tracer [125I]-[D-Lys6]-GnRH radioligand in rat pitui... |
J Med Chem 44: 3645-52 (2001)
BindingDB Entry DOI: 10.7270/Q2W66K2Z |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50105861
(CHEMBL414239 | pGlu-His-Trp-Ser-Tyr-D-Lys(N-(2 chl...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(=O)CC=Nc1c(O)c2ccccc2c(O)c1Cl)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NOC(=O)C1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O |w:17.16| Show InChI InChI=1S/C72H92ClN19O17/c1-38(2)29-50(64(101)86-48(16-9-26-80-72(75)76)70(107)92-28-10-17-55(92)69(106)82-35-56(74)95)87-63(100)47(15-7-8-25-78-57(96)24-27-79-60-59(73)61(98)44-12-3-4-13-45(44)62(60)99)85-65(102)51(30-39-18-20-42(94)21-19-39)88-68(105)54(36-93)90-66(103)52(31-40-33-81-46-14-6-5-11-43(40)46)89-67(104)53(32-41-34-77-37-83-41)91-109-71(108)49-22-23-58(97)84-49/h3-6,11-14,18-21,27,33-34,37-38,47-55,81,91,93-94,98-99H,7-10,15-17,22-26,28-32,35-36H2,1-2H3,(H2,74,95)(H,77,83)(H,78,96)(H,82,106)(H,84,97)(H,85,102)(H,86,101)(H,87,100)(H,88,105)(H,89,104)(H,90,103)(H4,75,76,80)/t47-,48-,49?,50-,51-,52-,53-,54-,55-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description
Evaluated for gonadotropin-releasing hormone receptor binding by displacing the 50% of the bound tracer [125I]-[D-Lys6]-GnRH radioligand in rat pitui... |
J Med Chem 44: 3645-52 (2001)
BindingDB Entry DOI: 10.7270/Q2W66K2Z |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50105863
(CHEMBL438099 | pGlu-His-Trp-Ser-Tyr-D-Lys(emodic a...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNCc1cc(O)c2C(=O)c3c(O)cc(cc3C(=O)c2c1)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NOC(=O)C1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O Show InChI InChI=1S/C75H92N18O20/c1-37(2)23-51(66(103)87-49(12-7-21-81-75(77)78)72(109)93-22-8-13-56(93)71(108)83-34-59(76)98)88-65(102)48(11-5-6-20-79-31-39-24-45-61(57(96)26-39)64(101)62-46(63(45)100)27-40(73(110)111)29-58(62)97)86-67(104)52(25-38-14-16-43(95)17-15-38)89-70(107)55(35-94)91-68(105)53(28-41-32-82-47-10-4-3-9-44(41)47)90-69(106)54(30-42-33-80-36-84-42)92-113-74(112)50-18-19-60(99)85-50/h3-4,9-10,14-17,24,26-27,29,32-33,36-37,48-56,79,82,92,94-97H,5-8,11-13,18-23,25,28,30-31,34-35H2,1-2H3,(H2,76,98)(H,80,84)(H,83,108)(H,85,99)(H,86,104)(H,87,103)(H,88,102)(H,89,107)(H,90,106)(H,91,105)(H,110,111)(H4,77,78,81)/t48-,49-,50?,51-,52-,53-,54-,55-,56-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description
Evaluated for gonadotropin-releasing hormone receptor binding by displacing the 50% of the bound tracer [125I]-[D-Lys6]-GnRH radioligand in rat pitui... |
J Med Chem 44: 3645-52 (2001)
BindingDB Entry DOI: 10.7270/Q2W66K2Z |
More data for this
Ligand-Target Pair | |
Search and Browse
