Affinity Data by PubMed id=11606139

PubMed code 11606139

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50105987 (CHEMBL125441 \| [5-(1-Benzyl-6-methoxy-1H-indazol-3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50105986 (1-Benzyl-6-fluoro-3-(5-methoxymethyl-furan-2-yl)-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50105994 (CHEMBL440716 \| [5-(1-Benzyl-6-methyl-1H-indazol-3-...) Show SMILES Cc1ccc2c(nn(Cc3ccccc3)c2c1)-c1ccc(CO)o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50106010 (1-Benzyl-3-(5-methoxymethyl-furan-2-yl)-6-methyl-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50105983 (1-Benzyl-3-(5-methoxymethyl-furan-2-yl)-1H-indazol...) Show SMILES COCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50105999 (CHEMBL123034 \| [5-(1-Benzyl-6-fluoro-1H-indazol-3-...) Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2cc(F)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50105989 (1-Benzyl-3-(5-methyl-furan-2-yl)-1H-indazole \| CHE...) Show SMILES Cc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50095469 ((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol \|...) Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50106006 (CHEMBL340558 \| [5-(1-Phenyl-1H-indazol-3-yl)-furan...) Show SMILES OCc1ccc(o1)-c1nn(-c2ccccc2)c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50105996 (CHEMBL121831 \| [5-(1-Benzyl-1H-indazol-3-yl)-furan...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM15336 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) Show SMILES CC(C)Cn1c2nc[nH]c2c(=O)n(C)c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	6.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of PDE5 from platelets				J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%