Found 14 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108781
(2-{[1-(2-Amino-3-mercapto-propionyl)-piperidin-4-y...)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(CC1)C(=O)C(N)CS)C(=O)c1ccccc1 Show InChI InChI=1S/C21H31N3O4S2/c1-28-21(27)18(10-13-30-2)24(19(25)15-6-4-3-5-7-15)16-8-11-23(12-9-16)20(26)17(22)14-29/h3-7,16-18,29H,8-14,22H2,1-2H3/t17?,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLS |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108780
(2-{2-[4-(2-Amino-3-methylsulfanyl-propylamino)-3-m...)Show SMILES CSCCC(NC(=O)[C@H](Cc1ccccc1)NCC[C@@H](C)CNC[C@H](N)CSC)C(O)=O Show InChI InChI=1S/C23H40N4O3S2/c1-17(14-25-15-19(24)16-32-3)9-11-26-21(13-18-7-5-4-6-8-18)22(28)27-20(23(29)30)10-12-31-2/h4-8,17,19-21,25-26H,9-16,24H2,1-3H3,(H,27,28)(H,29,30)/t17-,19+,20?,21+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLS |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048955
((S)-2-[4-((R)-2-Amino-3-mercapto-propionylamino)-b...)Show SMILES CSCC[C@H](NC(=O)c1ccc(NC(=O)[C@@H](N)CS)cc1)C(O)=O Show InChI InChI=1S/C15H21N3O4S2/c1-24-7-6-12(15(21)22)18-13(19)9-2-4-10(5-3-9)17-14(20)11(16)8-23/h2-5,11-12,23H,6-8,16H2,1H3,(H,17,20)(H,18,19)(H,21,22)/t11-,12-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLS |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108780
(2-{2-[4-(2-Amino-3-methylsulfanyl-propylamino)-3-m...)Show SMILES CSCCC(NC(=O)[C@H](Cc1ccccc1)NCC[C@@H](C)CNC[C@H](N)CSC)C(O)=O Show InChI InChI=1S/C23H40N4O3S2/c1-17(14-25-15-19(24)16-32-3)9-11-26-21(13-18-7-5-4-6-8-18)22(28)27-20(23(29)30)10-12-31-2/h4-8,17,19-21,25-26H,9-16,24H2,1-3H3,(H,27,28)(H,29,30)/t17-,19+,20?,21+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I (GGPT I) catalyzed transfer of GGPP to dansyl-GCVLL |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108784
(2-{Benzoyl-[1-(1H-imidazol-4-ylmethyl)-piperidin-4...)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(Cc2cnc[nH]2)CC1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H30N4O3S/c1-29-22(28)20(10-13-30-2)26(21(27)17-6-4-3-5-7-17)19-8-11-25(12-9-19)15-18-14-23-16-24-18/h3-7,14,16,19-20H,8-13,15H2,1-2H3,(H,23,24)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLS |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108785
(2-[Benzoyl-(1-thiazol-4-ylmethyl-piperidin-4-yl)-a...)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(Cc2cscn2)CC1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H29N3O3S2/c1-28-22(27)20(10-13-29-2)25(21(26)17-6-4-3-5-7-17)19-8-11-24(12-9-19)14-18-15-30-16-23-18/h3-7,15-16,19-20H,8-14H2,1-2H3/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLS |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108783
(2-{Benzoyl-[1-(thiazole-4-carbonyl)-piperidin-4-yl...)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(CC1)C(=O)c1cscn1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H27N3O4S2/c1-29-22(28)19(10-13-30-2)25(20(26)16-6-4-3-5-7-16)17-8-11-24(12-9-17)21(27)18-14-31-15-23-18/h3-7,14-15,17,19H,8-13H2,1-2H3/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLS |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108785
(2-[Benzoyl-(1-thiazol-4-ylmethyl-piperidin-4-yl)-a...)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(Cc2cscn2)CC1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H29N3O3S2/c1-28-22(27)20(10-13-29-2)25(21(26)17-6-4-3-5-7-17)19-8-11-24(12-9-19)14-18-15-30-16-23-18/h3-7,15-16,19-20H,8-14H2,1-2H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I (GGPT I) catalyzed transfer of GGPP to dansyl-GCVLL |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108784
(2-{Benzoyl-[1-(1H-imidazol-4-ylmethyl)-piperidin-4...)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(Cc2cnc[nH]2)CC1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H30N4O3S/c1-29-22(28)20(10-13-30-2)26(21(27)17-6-4-3-5-7-17)19-8-11-25(12-9-19)15-18-14-23-16-24-18/h3-7,14,16,19-20H,8-13,15H2,1-2H3,(H,23,24)/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I (GGPT I) catalyzed transfer of GGPP to dansyl-GCVLL |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048955
((S)-2-[4-((R)-2-Amino-3-mercapto-propionylamino)-b...)Show SMILES CSCC[C@H](NC(=O)c1ccc(NC(=O)[C@@H](N)CS)cc1)C(O)=O Show InChI InChI=1S/C15H21N3O4S2/c1-24-7-6-12(15(21)22)18-13(19)9-2-4-10(5-3-9)17-14(20)11(16)8-23/h2-5,11-12,23H,6-8,16H2,1H3,(H,17,20)(H,18,19)(H,21,22)/t11-,12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I (GGPT I) catalyzed transfer of GGPP to dansyl-GCVLL |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108781
(2-{[1-(2-Amino-3-mercapto-propionyl)-piperidin-4-y...)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(CC1)C(=O)C(N)CS)C(=O)c1ccccc1 Show InChI InChI=1S/C21H31N3O4S2/c1-28-21(27)18(10-13-30-2)24(19(25)15-6-4-3-5-7-15)16-8-11-23(12-9-16)20(26)17(22)14-29/h3-7,16-18,29H,8-14,22H2,1-2H3/t17?,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I (GGPT I) catalyzed transfer of GGPP to dansyl-GCVLL |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108783
(2-{Benzoyl-[1-(thiazole-4-carbonyl)-piperidin-4-yl...)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(CC1)C(=O)c1cscn1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H27N3O4S2/c1-29-22(28)19(10-13-30-2)25(20(26)16-6-4-3-5-7-16)17-8-11-24(12-9-17)21(27)18-14-31-15-23-18/h3-7,14-15,17,19H,8-13H2,1-2H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I (GGPT I) catalyzed transfer of GGPP to dansyl-GCVLL |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108786
(2-(Benzoyl-piperidin-4-yl-amino)-4-methylsulfanyl-...)Show InChI InChI=1S/C18H26N2O3S/c1-23-18(22)16(10-13-24-2)20(15-8-11-19-12-9-15)17(21)14-6-4-3-5-7-14/h3-7,15-16,19H,8-13H2,1-2H3/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLS |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50409604
(CHEMBL2094059)Show SMILES COC(=O)[C@H](CCSC)N(C1CCN(CC1)C(=O)[C@@H]1CSCN1)C(=O)c1ccccc1 |r| Show InChI InChI=1S/C22H31N3O4S2/c1-29-22(28)19(10-13-30-2)25(20(26)16-6-4-3-5-7-16)17-8-11-24(12-9-17)21(27)18-14-31-15-23-18/h3-7,17-19,23H,8-15H2,1-2H3/t18-,19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I (GGPT I) catalyzed transfer of GGPP to dansyl-GCVLL |
J Med Chem 45: 533-6 (2002)
BindingDB Entry DOI: 10.7270/Q29Z95N2 |
More data for this
Ligand-Target Pair | |
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