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PubMed code 11844663

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22971
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
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n/an/a 40n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22971
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
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n/an/a 50n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109676
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-octyl-benz...)
Show SMILES CCCCCCCCNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C22H28Cl2N2O/c1-3-4-5-6-7-10-15-25-22(27)17-11-8-9-12-19(17)26-21-18(23)14-13-16(2)20(21)24/h8-9,11-14,26H,3-7,10,15H2,1-2H3,(H,25,27)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109676
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-octyl-benz...)
Show SMILES CCCCCCCCNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C22H28Cl2N2O/c1-3-4-5-6-7-10-15-25-22(27)17-11-8-9-12-19(17)26-21-18(23)14-13-16(2)20(21)24/h8-9,11-14,26H,3-7,10,15H2,1-2H3,(H,25,27)
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n/an/a 60n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22973
PNG
(CHEMBL149213 | Meclofenamic acid derivative, 25 | ...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCCCl)c1Cl
Show InChI InChI=1S/C17H17Cl3N2O/c1-11-7-8-13(19)16(15(11)20)22-14-6-3-2-5-12(14)17(23)21-10-4-9-18/h2-3,5-8,22H,4,9-10H2,1H3,(H,21,23)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22979
PNG
(CHEMBL148629 | Meclofenamic acid derivative, 31 | ...)
Show SMILES COC(=O)CNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C17H16Cl2N2O3/c1-10-7-8-12(18)16(15(10)19)21-13-6-4-3-5-11(13)17(23)20-9-14(22)24-2/h3-8,21H,9H2,1-2H3,(H,20,23)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109680
PNG
(CHEMBL356203 | N-(2-Bromo-ethyl)-2-(2,6-dichloro-3...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCBr)c1Cl
Show InChI InChI=1S/C16H15BrCl2N2O/c1-10-6-7-12(18)15(14(10)19)21-13-5-3-2-4-11(13)16(22)20-9-8-17/h2-7,21H,8-9H2,1H3,(H,20,22)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50029593
PNG
(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1OC1CCCCC1)[N+]([O-])=O
Show InChI InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109681
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-(2-methoxy...)
Show SMILES COCCNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C17H18Cl2N2O2/c1-11-7-8-13(18)16(15(11)19)21-14-6-4-3-5-12(14)17(22)20-9-10-23-2/h3-8,21H,9-10H2,1-2H3,(H,20,22)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22975
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCOc2ccccc2)c1Cl
Show InChI InChI=1S/C22H20Cl2N2O2/c1-15-11-12-18(23)21(20(15)24)26-19-10-6-5-9-17(19)22(27)25-13-14-28-16-7-3-2-4-8-16/h2-12,26H,13-14H2,1H3,(H,25,27)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM22971
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the murine wild type Prostaglandin G/H synthase 2

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22977
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-[(4-nitro...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NOCc2ccc(cc2)[N+]([O-])=O)c1Cl
Show InChI InChI=1S/C21H17Cl2N3O4/c1-13-6-11-17(22)20(19(13)23)24-18-5-3-2-4-16(18)21(27)25-30-12-14-7-9-15(10-8-14)26(28)29/h2-11,24H,12H2,1H3,(H,25,27)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109685
PNG
(CHEMBL149335 | [2-(2,6-Dichloro-3-methyl-phenylami...)
Show SMILES CCOC(=O)CNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-3-25-15(23)10-21-18(24)12-6-4-5-7-14(12)22-17-13(19)9-8-11(2)16(17)20/h4-9,22H,3,10H2,1-2H3,(H,21,24)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109678
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-(3-methoxy...)
Show SMILES COCCCNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C18H20Cl2N2O2/c1-12-8-9-14(19)17(16(12)20)22-15-7-4-3-6-13(15)18(23)21-10-5-11-24-2/h3-4,6-9,22H,5,10-11H2,1-2H3,(H,21,23)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22980
PNG
(2-({2-[(2,6-dichloro-3-methylphenyl)amino]phenyl}f...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCC(O)=O)c1Cl
Show InChI InChI=1S/C16H14Cl2N2O3/c1-9-6-7-11(17)15(14(9)18)20-12-5-3-2-4-10(12)16(23)19-8-13(21)22/h2-7,20H,8H2,1H3,(H,19,23)(H,21,22)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22980
PNG
(2-({2-[(2,6-dichloro-3-methylphenyl)amino]phenyl}f...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCC(O)=O)c1Cl
Show InChI InChI=1S/C16H14Cl2N2O3/c1-9-6-7-11(17)15(14(9)18)20-12-5-3-2-4-10(12)16(23)19-8-13(21)22/h2-7,20H,8H2,1H3,(H,19,23)(H,21,22)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM22975
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCOc2ccccc2)c1Cl
Show InChI InChI=1S/C22H20Cl2N2O2/c1-15-11-12-18(23)21(20(15)24)26-19-10-6-5-9-17(19)22(27)25-13-14-28-16-7-3-2-4-8-16/h2-12,26H,13-14H2,1H3,(H,25,27)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the wild type murine Prostaglandin G/H synthase 2 wildtype enzyme

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM22971
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the murine Arg120Ala mutant type COX-2

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50012888
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-methoxy-be...)
Show SMILES CONC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C15H14Cl2N2O2/c1-9-7-8-11(16)14(13(9)17)18-12-6-4-3-5-10(12)15(20)19-21-2/h3-8,18H,1-2H3,(H,19,20)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM22975
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCOc2ccccc2)c1Cl
Show InChI InChI=1S/C22H20Cl2N2O2/c1-15-11-12-18(23)21(20(15)24)26-19-10-6-5-9-17(19)22(27)25-13-14-28-16-7-3-2-4-8-16/h2-12,26H,13-14H2,1H3,(H,25,27)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the Arg120Ala murine COX-2 mutant enzyme

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22974
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-hydrox...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCO)c1Cl
Show InChI InChI=1S/C16H16Cl2N2O2/c1-10-6-7-12(17)15(14(10)18)20-13-5-3-2-4-11(13)16(22)19-8-9-21/h2-7,20-21H,8-9H2,1H3,(H,19,22)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109687
PNG
((S)-2-[2-(2,6-Dichloro-3-methyl-phenylamino)-benzo...)
Show SMILES COC(=O)[C@H](C)NC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-10-8-9-13(19)16(15(10)20)22-14-7-5-4-6-12(14)17(23)21-11(2)18(24)25-3/h4-9,11,22H,1-3H3,(H,21,23)/t11-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22974
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-hydrox...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCO)c1Cl
Show InChI InChI=1S/C16H16Cl2N2O2/c1-10-6-7-12(17)15(14(10)18)20-13-5-3-2-4-11(13)16(22)19-8-9-21/h2-7,20-21H,8-9H2,1H3,(H,19,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22976
PNG
(CHEMBL358222 | Meclofenamic acid derivative, 28 | ...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NOCc2ccccc2)c1Cl
Show InChI InChI=1S/C21H18Cl2N2O2/c1-14-11-12-17(22)20(19(14)23)24-18-10-6-5-9-16(18)21(26)25-27-13-15-7-3-2-4-8-15/h2-12,24H,13H2,1H3,(H,25,26)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22979
PNG
(CHEMBL148629 | Meclofenamic acid derivative, 31 | ...)
Show SMILES COC(=O)CNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C17H16Cl2N2O3/c1-10-7-8-12(18)16(15(10)19)21-13-6-4-3-5-11(13)17(23)20-9-14(22)24-2/h3-8,21H,9H2,1-2H3,(H,20,23)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22972
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-methylben...)
Show SMILES CNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C15H14Cl2N2O/c1-9-7-8-11(16)14(13(9)17)19-12-6-4-3-5-10(12)15(20)18-2/h3-8,19H,1-2H3,(H,18,20)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22972
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-methylben...)
Show SMILES CNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C15H14Cl2N2O/c1-9-7-8-11(16)14(13(9)17)19-12-6-4-3-5-10(12)15(20)18-2/h3-8,19H,1-2H3,(H,18,20)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109680
PNG
(CHEMBL356203 | N-(2-Bromo-ethyl)-2-(2,6-dichloro-3...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCBr)c1Cl
Show InChI InChI=1S/C16H15BrCl2N2O/c1-10-6-7-12(18)15(14(10)19)21-13-5-3-2-4-11(13)16(22)20-9-8-17/h2-7,21H,8-9H2,1H3,(H,20,22)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22973
PNG
(CHEMBL149213 | Meclofenamic acid derivative, 25 | ...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCCCl)c1Cl
Show InChI InChI=1S/C17H17Cl3N2O/c1-11-7-8-13(19)16(15(11)20)22-14-6-3-2-5-12(14)17(23)21-10-4-9-18/h2-3,5-8,22H,4,9-10H2,1H3,(H,21,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109687
PNG
((S)-2-[2-(2,6-Dichloro-3-methyl-phenylamino)-benzo...)
Show SMILES COC(=O)[C@H](C)NC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-10-8-9-13(19)16(15(10)20)22-14-7-5-4-6-12(14)17(23)21-11(2)18(24)25-3/h4-9,11,22H,1-3H3,(H,21,23)/t11-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109682
PNG
((R)-2-[2-(2,6-Dichloro-3-methyl-phenylamino)-benzo...)
Show SMILES COC(=O)[C@@H](C)NC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-10-8-9-13(19)16(15(10)20)22-14-7-5-4-6-12(14)17(23)21-11(2)18(24)25-3/h4-9,11,22H,1-3H3,(H,21,23)/t11-/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109681
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-(2-methoxy...)
Show SMILES COCCNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C17H18Cl2N2O2/c1-11-7-8-13(18)16(15(11)19)21-14-6-4-3-5-12(14)17(22)20-9-10-23-2/h3-8,21H,9-10H2,1-2H3,(H,20,22)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109686
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-benzoic acid...)
Show SMILES COC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C15H13Cl2NO2/c1-9-7-8-11(16)14(13(9)17)18-12-6-4-3-5-10(12)15(19)20-2/h3-8,18H,1-2H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109685
PNG
(CHEMBL149335 | [2-(2,6-Dichloro-3-methyl-phenylami...)
Show SMILES CCOC(=O)CNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-3-25-15(23)10-21-18(24)12-6-4-5-7-14(12)22-17-13(19)9-8-11(2)16(17)20/h4-9,22H,3,10H2,1-2H3,(H,21,24)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22978
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenyl...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCc2ccccc2)c1Cl
Show InChI InChI=1S/C22H20Cl2N2O/c1-15-11-12-18(23)21(20(15)24)26-19-10-6-5-9-17(19)22(27)25-14-13-16-7-3-2-4-8-16/h2-12,26H,13-14H2,1H3,(H,25,27)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM22978
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenyl...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCc2ccccc2)c1Cl
Show InChI InChI=1S/C22H20Cl2N2O/c1-15-11-12-18(23)21(20(15)24)26-19-10-6-5-9-17(19)22(27)25-14-13-16-7-3-2-4-8-16/h2-12,26H,13-14H2,1H3,(H,25,27)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109675
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-benzoic acid...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NNCc2ccccc2)c1Cl
Show InChI InChI=1S/C21H19Cl2N3O/c1-14-11-12-17(22)20(19(14)23)25-18-10-6-5-9-16(18)21(27)26-24-13-15-7-3-2-4-8-15/h2-12,24-25H,13H2,1H3,(H,26,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109684
PNG
((S)-2-[2-(2,6-Dichloro-3-methyl-phenylamino)-benzo...)
Show SMILES C[C@H](NC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl)C(O)=O
Show InChI InChI=1S/C17H16Cl2N2O3/c1-9-7-8-12(18)15(14(9)19)21-13-6-4-3-5-11(13)16(22)20-10(2)17(23)24/h3-8,10,21H,1-2H3,(H,20,22)(H,23,24)/t10-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109682
PNG
((R)-2-[2-(2,6-Dichloro-3-methyl-phenylamino)-benzo...)
Show SMILES COC(=O)[C@@H](C)NC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-10-8-9-13(19)16(15(10)20)22-14-7-5-4-6-12(14)17(23)21-11(2)18(24)25-3/h4-9,11,22H,1-3H3,(H,21,23)/t11-/m1/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109675
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-benzoic acid...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NNCc2ccccc2)c1Cl
Show InChI InChI=1S/C21H19Cl2N3O/c1-14-11-12-17(22)20(19(14)23)25-18-10-6-5-9-16(18)21(27)26-24-13-15-7-3-2-4-8-15/h2-12,24-25H,13H2,1H3,(H,26,27)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109677
PNG
((R)-2-[2-(2,6-Dichloro-3-methyl-phenylamino)-benzo...)
Show SMILES C[C@@H](NC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl)C(O)=O
Show InChI InChI=1S/C17H16Cl2N2O3/c1-9-7-8-12(18)15(14(9)19)21-13-6-4-3-5-11(13)16(22)20-10(2)17(23)24/h3-8,10,21H,1-2H3,(H,20,22)(H,23,24)/t10-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109683
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-isopropoxy...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NOC(C)(C)C)c1Cl
Show InChI InChI=1S/C18H20Cl2N2O2/c1-11-9-10-13(19)16(15(11)20)21-14-8-6-5-7-12(14)17(23)22-24-18(2,3)4/h5-10,21H,1-4H3,(H,22,23)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109678
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-(3-methoxy...)
Show SMILES COCCCNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C18H20Cl2N2O2/c1-12-8-9-14(19)17(16(12)20)22-15-7-4-3-6-13(15)18(23)21-10-5-11-24-2/h3-4,6-9,22H,5,10-11H2,1-2H3,(H,21,23)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109686
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-benzoic acid...)
Show SMILES COC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C15H13Cl2NO2/c1-9-7-8-11(16)14(13(9)17)18-12-6-4-3-5-10(12)15(19)20-2/h3-8,18H,1-2H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50109679
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-benzoic acid...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccccc2Nc2c(Cl)ccc(C)c2Cl)cc1
Show InChI InChI=1S/C22H18Cl2N2O3/c1-13-7-12-18(23)21(20(13)24)26-19-6-4-3-5-17(19)22(28)29-16-10-8-15(9-11-16)25-14(2)27/h3-12,26H,1-2H3,(H,25,27)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109679
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-benzoic acid...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccccc2Nc2c(Cl)ccc(C)c2Cl)cc1
Show InChI InChI=1S/C22H18Cl2N2O3/c1-13-7-12-18(23)21(20(13)24)26-19-6-4-3-5-17(19)22(28)29-16-10-8-15(9-11-16)25-14(2)27/h3-12,26H,1-2H3,(H,25,27)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109677
PNG
((R)-2-[2-(2,6-Dichloro-3-methyl-phenylamino)-benzo...)
Show SMILES C[C@@H](NC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl)C(O)=O
Show InChI InChI=1S/C17H16Cl2N2O3/c1-9-7-8-12(18)15(14(9)19)21-13-6-4-3-5-11(13)16(22)20-10(2)17(23)24/h3-8,10,21H,1-2H3,(H,20,22)(H,23,24)/t10-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109684
PNG
((S)-2-[2-(2,6-Dichloro-3-methyl-phenylamino)-benzo...)
Show SMILES C[C@H](NC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl)C(O)=O
Show InChI InChI=1S/C17H16Cl2N2O3/c1-9-7-8-12(18)15(14(9)19)21-13-6-4-3-5-11(13)16(22)20-10(2)17(23)24/h3-8,10,21H,1-2H3,(H,20,22)(H,23,24)/t10-/m0/s1
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n/an/a 3.30E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50012888
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-methoxy-be...)
Show SMILES CONC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl
Show InChI InChI=1S/C15H14Cl2N2O2/c1-9-7-8-11(16)14(13(9)17)18-12-6-4-3-5-10(12)15(20)19-21-2/h3-8,18H,1-2H3,(H,19,20)
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n/an/a 5.50E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50109683
PNG
(2-(2,6-Dichloro-3-methyl-phenylamino)-N-isopropoxy...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NOC(C)(C)C)c1Cl
Show InChI InChI=1S/C18H20Cl2N2O2/c1-11-9-10-13(19)16(15(11)20)21-14-8-6-5-7-12(14)17(23)22-24-18(2,3)4/h5-10,21H,1-4H3,(H,22,23)
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n/an/a 6.60E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22977
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-[(4-nitro...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NOCc2ccc(cc2)[N+]([O-])=O)c1Cl
Show InChI InChI=1S/C21H17Cl2N3O4/c1-13-6-11-17(22)20(19(13)23)24-18-5-3-2-4-16(18)21(27)25-30-12-14-7-9-15(10-8-14)26(28)29/h2-11,24H,12H2,1H3,(H,25,27)
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n/an/a 6.60E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22976
PNG
(CHEMBL358222 | Meclofenamic acid derivative, 28 | ...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NOCc2ccccc2)c1Cl
Show InChI InChI=1S/C21H18Cl2N2O2/c1-14-11-12-17(22)20(19(14)23)24-18-10-6-5-9-16(18)21(26)25-27-13-15-7-3-2-4-8-15/h2-12,24H,13H2,1H3,(H,25,26)
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n/an/a 6.60E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))		BDBM50029593
PNG
(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1OC1CCCCC1)[N+]([O-])=O
Show InChI InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
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n/an/a>6.60E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM22975
PNG
(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCOc2ccccc2)c1Cl
Show InChI InChI=1S/C22H20Cl2N2O2/c1-15-11-12-18(23)21(20(15)24)26-19-10-6-5-9-17(19)22(27)25-13-14-28-16-7-3-2-4-8-16/h2-12,26H,13-14H2,1H3,(H,25,27)
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n/an/a 6.60E+4n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay

Bioorg Med Chem Lett 12: 521-4 (2002)


BindingDB Entry DOI: 10.7270/Q2BP0247
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%