Affinity Data by PubMed id=11855979

PubMed code 11855979

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110208 (4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110205 (4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110202 ((4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110200 (4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110206 (3-(benzo[d][1,3]dioxol-5-yl)-2-(pyridin-2-yl)-6,7-...) Show SMILES C1Cc2nc(c(-c3ccc4OCOc4c3)n2C1)-c1ccccn1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110199 (4-(4-(4-fluorophenyl)-5-(pyridin-2-yl)-1H-imidazol...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110201 (5-(4-Fluoro-phenyl)-6-pyridin-2-yl-2,3-dihydro-imi...) Show SMILES Fc1ccc(cc1)-c1c(nc2SCCn12)-c1ccccn1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110197 (4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110198 (3-(4-Methoxy-phenyl)-2-pyridin-2-yl-6,7-dihydro-5H...) Show SMILES COc1ccc(cc1)-c1c(nc2CCCn12)-c1ccccn1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110203 (3-(4-Fluoro-phenyl)-2-pyridin-2-yl-6,7-dihydro-5H-...) Show SMILES Fc1ccc(cc1)-c1c(nc2CCCn12)-c1ccccn1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM13336 (4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110207 (3-(4-Fluoro-phenyl)-2-pyridin-3-yl-6,7-dihydro-5H-...) Show SMILES Fc1ccc(cc1)-c1c(nc2CCCn12)-c1cccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110204 (5-(4-Fluoro-phenyl)-6-pyridin-4-yl-2,3-dihydro-imi...) Show SMILES Fc1ccc(cc1)-c1c(nc2SCCn12)-c1ccncc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Activin like receptor kinase 5, TGF beta type I receptor				J Med Chem 45: 999-1001 (2002) BindingDB Entry DOI: 10.7270/Q2154GBF
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%