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PubMed code 11909711

Compile data set for download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111167
PNG
(2-Amino-5-guanidino-pentanoic acid naphthalen-1-yl...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C28H31N5O/c29-26(13-6-16-32-28(30)31)27(34)33(18-20-14-15-21-7-1-2-9-23(21)17-20)19-24-11-5-10-22-8-3-4-12-25(22)24/h1-5,7-12,14-15,17,26H,6,13,16,18-19,29H2,(H4,30,31,32)/t26-/m0/s1
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 690n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111167
PNG
(2-Amino-5-guanidino-pentanoic acid naphthalen-1-yl...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C28H31N5O/c29-26(13-6-16-32-28(30)31)27(34)33(18-20-14-15-21-7-1-2-9-23(21)17-20)19-24-11-5-10-22-8-3-4-12-25(22)24/h1-5,7-12,14-15,17,26H,6,13,16,18-19,29H2,(H4,30,31,32)/t26-/m0/s1
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 690n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111156
PNG
(CHEMBL269776 | N-(3-Amino-propyl)-3-[(1H-indol-3-y...)
Show SMILES NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H31N5O/c27-12-5-13-29-26(32)25(18-28-16-22-17-31-24-9-4-3-8-23(22)24)30-15-19-10-11-20-6-1-2-7-21(20)14-19/h1-4,6-11,14,17,25,28,30-31H,5,12-13,15-16,18,27H2,(H,29,32)/t25-/m0/s1
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 700n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50451494
PNG
(CHEMBL2113315)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)Cc1ccc2ccccc2c1 |wD:1.1,(7.16,-11.51,;7.16,-9.97,;8.68,-9.8,;9.45,-8.45,;10.97,-8.73,;11.93,-7.56,;13.38,-8.1,;13.66,-9.64,;14.55,-7.16,;5.83,-9.2,;4.5,-9.97,;5.83,-7.65,;7.16,-6.88,;7.16,-5.34,;8.5,-4.57,;9.9,-5.2,;10.94,-4.05,;10.17,-2.72,;10.65,-1.25,;9.62,-.1,;8.1,-.43,;7.63,-1.9,;8.66,-3.04,;4.5,-6.88,;3.16,-7.65,;3.14,-9.2,;1.81,-9.97,;.48,-9.2,;-.86,-9.97,;-2.19,-9.2,;-2.19,-7.65,;-.86,-6.88,;.48,-7.65,;1.81,-6.88,)|
Show InChI InChI=1S/C27H32N6O/c28-24(9-5-14-31-27(29)30)26(34)33(15-13-22-17-32-25-10-4-3-8-23(22)25)18-19-11-12-20-6-1-2-7-21(20)16-19/h1-4,6-8,10-12,16-17,24,32H,5,9,13-15,18,28H2,(H4,29,30,31)/t24-/m0/s1
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 1.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111173
PNG
(6-(3-Naphthalen-2-ylmethyl-3-naphthalen-1-ylmethyl...)
Show SMILES OC(=O)CCCCCNC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C29H30N2O3/c32-28(33)15-2-1-7-18-30-29(34)31(20-22-16-17-23-9-3-4-11-25(23)19-22)21-26-13-8-12-24-10-5-6-14-27(24)26/h3-6,8-14,16-17,19H,1-2,7,15,18,20-21H2,(H,30,34)(H,32,33)
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 1.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111173
PNG
(6-(3-Naphthalen-2-ylmethyl-3-naphthalen-1-ylmethyl...)
Show SMILES OC(=O)CCCCCNC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C29H30N2O3/c32-28(33)15-2-1-7-18-30-29(34)31(20-22-16-17-23-9-3-4-11-25(23)19-22)21-26-13-8-12-24-10-5-6-14-27(24)26/h3-6,8-14,16-17,19H,1-2,7,15,18,20-21H2,(H,30,34)(H,32,33)
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 2.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111167
PNG
(2-Amino-5-guanidino-pentanoic acid naphthalen-1-yl...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C28H31N5O/c29-26(13-6-16-32-28(30)31)27(34)33(18-20-14-15-21-7-1-2-9-23(21)17-20)19-24-11-5-10-22-8-3-4-12-25(22)24/h1-5,7-12,14-15,17,26H,6,13,16,18-19,29H2,(H4,30,31,32)/t26-/m0/s1
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 2.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111167
PNG
(2-Amino-5-guanidino-pentanoic acid naphthalen-1-yl...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C28H31N5O/c29-26(13-6-16-32-28(30)31)27(34)33(18-20-14-15-21-7-1-2-9-23(21)17-20)19-24-11-5-10-22-8-3-4-12-25(22)24/h1-5,7-12,14-15,17,26H,6,13,16,18-19,29H2,(H4,30,31,32)/t26-/m0/s1
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 2.70E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111173
PNG
(6-(3-Naphthalen-2-ylmethyl-3-naphthalen-1-ylmethyl...)
Show SMILES OC(=O)CCCCCNC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C29H30N2O3/c32-28(33)15-2-1-7-18-30-29(34)31(20-22-16-17-23-9-3-4-11-25(23)19-22)21-26-13-8-12-24-10-5-6-14-27(24)26/h3-6,8-14,16-17,19H,1-2,7,15,18,20-21H2,(H,30,34)(H,32,33)
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 4.10E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111167
PNG
(2-Amino-5-guanidino-pentanoic acid naphthalen-1-yl...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C28H31N5O/c29-26(13-6-16-32-28(30)31)27(34)33(18-20-14-15-21-7-1-2-9-23(21)17-20)19-24-11-5-10-22-8-3-4-12-25(22)24/h1-5,7-12,14-15,17,26H,6,13,16,18-19,29H2,(H4,30,31,32)/t26-/m0/s1
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 5.40E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111167
PNG
(2-Amino-5-guanidino-pentanoic acid naphthalen-1-yl...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C28H31N5O/c29-26(13-6-16-32-28(30)31)27(34)33(18-20-14-15-21-7-1-2-9-23(21)17-20)19-24-11-5-10-22-8-3-4-12-25(22)24/h1-5,7-12,14-15,17,26H,6,13,16,18-19,29H2,(H4,30,31,32)/t26-/m0/s1
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 5.40E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111174
PNG
(CHEMBL8743 | N*1*-Naphthalen-2-ylmethyl-ethane-1,2...)
Show SMILES NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C13H16N2/c14-7-8-15-10-11-5-6-12-3-1-2-4-13(12)9-11/h1-6,9,15H,7-8,10,14H2
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 8.80E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111167
PNG
(2-Amino-5-guanidino-pentanoic acid naphthalen-1-yl...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C28H31N5O/c29-26(13-6-16-32-28(30)31)27(34)33(18-20-14-15-21-7-1-2-9-23(21)17-20)19-24-11-5-10-22-8-3-4-12-25(22)24/h1-5,7-12,14-15,17,26H,6,13,16,18-19,29H2,(H4,30,31,32)/t26-/m0/s1
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 9.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111167
PNG
(2-Amino-5-guanidino-pentanoic acid naphthalen-1-yl...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C28H31N5O/c29-26(13-6-16-32-28(30)31)27(34)33(18-20-14-15-21-7-1-2-9-23(21)17-20)19-24-11-5-10-22-8-3-4-12-25(22)24/h1-5,7-12,14-15,17,26H,6,13,16,18-19,29H2,(H4,30,31,32)/t26-/m0/s1
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 9.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111172
PNG
(6-[(1H-Indol-3-ylmethyl)-amino]-2-[(naphthalen-2-y...)
Show SMILES NCCCCNC(=O)[C@H](CCCCNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C30H39N5O/c31-16-6-8-18-33-30(36)29(34-20-23-14-15-24-9-1-2-10-25(24)19-23)13-5-7-17-32-21-26-22-35-28-12-4-3-11-27(26)28/h1-4,9-12,14-15,19,22,29,32,34-35H,5-8,13,16-18,20-21,31H2,(H,33,36)/t29-/m0/s1
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 9.80E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50451494
PNG
(CHEMBL2113315)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)Cc1ccc2ccccc2c1 |wD:1.1,(7.16,-11.51,;7.16,-9.97,;8.68,-9.8,;9.45,-8.45,;10.97,-8.73,;11.93,-7.56,;13.38,-8.1,;13.66,-9.64,;14.55,-7.16,;5.83,-9.2,;4.5,-9.97,;5.83,-7.65,;7.16,-6.88,;7.16,-5.34,;8.5,-4.57,;9.9,-5.2,;10.94,-4.05,;10.17,-2.72,;10.65,-1.25,;9.62,-.1,;8.1,-.43,;7.63,-1.9,;8.66,-3.04,;4.5,-6.88,;3.16,-7.65,;3.14,-9.2,;1.81,-9.97,;.48,-9.2,;-.86,-9.97,;-2.19,-9.2,;-2.19,-7.65,;-.86,-6.88,;.48,-7.65,;1.81,-6.88,)|
Show InChI InChI=1S/C27H32N6O/c28-24(9-5-14-31-27(29)30)26(34)33(15-13-22-17-32-25-10-4-3-8-23(22)25)18-19-11-12-20-6-1-2-7-21(20)16-19/h1-4,6-8,10-12,16-17,24,32H,5,9,13-15,18,28H2,(H4,29,30,31)/t24-/m0/s1
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 1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50451493
PNG
(CHEMBL2113280)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(Cc1c[nH]c2ccccc12)Cc1cccc2ccccc12 |wD:1.1,(9.22,-7.05,;9.22,-5.51,;10.74,-5.33,;11.51,-3.99,;13.02,-4.25,;13.98,-3.09,;15.43,-3.62,;15.71,-5.18,;16.59,-2.69,;7.89,-4.74,;6.56,-5.51,;7.89,-3.2,;6.56,-2.43,;5.23,-3.2,;5.05,-4.74,;3.55,-5.06,;2.8,-3.72,;1.29,-3.39,;.82,-1.92,;1.87,-.78,;3.37,-1.12,;3.83,-2.57,;9.22,-2.43,;9.22,-.89,;7.89,-.12,;7.89,1.42,;9.22,2.19,;10.55,1.42,;11.9,2.19,;13.23,1.42,;13.23,-.12,;11.9,-.89,;10.55,-.12,)|
Show InChI InChI=1S/C26H30N6O/c27-23(12-6-14-30-26(28)29)25(33)32(17-20-15-31-24-13-4-3-11-22(20)24)16-19-9-5-8-18-7-1-2-10-21(18)19/h1-5,7-11,13,15,23,31H,6,12,14,16-17,27H2,(H4,28,29,30)/t23-/m0/s1
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 1.10E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50451493
PNG
(CHEMBL2113280)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(Cc1c[nH]c2ccccc12)Cc1cccc2ccccc12 |wD:1.1,(9.22,-7.05,;9.22,-5.51,;10.74,-5.33,;11.51,-3.99,;13.02,-4.25,;13.98,-3.09,;15.43,-3.62,;15.71,-5.18,;16.59,-2.69,;7.89,-4.74,;6.56,-5.51,;7.89,-3.2,;6.56,-2.43,;5.23,-3.2,;5.05,-4.74,;3.55,-5.06,;2.8,-3.72,;1.29,-3.39,;.82,-1.92,;1.87,-.78,;3.37,-1.12,;3.83,-2.57,;9.22,-2.43,;9.22,-.89,;7.89,-.12,;7.89,1.42,;9.22,2.19,;10.55,1.42,;11.9,2.19,;13.23,1.42,;13.23,-.12,;11.9,-.89,;10.55,-.12,)|
Show InChI InChI=1S/C26H30N6O/c27-23(12-6-14-30-26(28)29)25(33)32(17-20-15-31-24-13-4-3-11-22(20)24)16-19-9-5-8-18-7-1-2-10-21(18)19/h1-5,7-11,13,15,23,31H,6,12,14,16-17,27H2,(H4,28,29,30)/t23-/m0/s1
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 1.20E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111169
PNG
(CHEMBL8742 | N-{3-[(1H-Indol-3-ylmethyl)-amino]-pr...)
Show SMILES NC(=N)NCCCNCc1c[nH]c2ccccc12
Show InChI InChI=1S/C13H19N5/c14-13(15)17-7-3-6-16-8-10-9-18-12-5-2-1-4-11(10)12/h1-2,4-5,9,16,18H,3,6-8H2,(H4,14,15,17)
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 1.20E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111160
PNG
(CHEMBL8045 | [2-(1H-Indol-3-yl)-ethyl]-naphthalen-...)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C21H20N2/c1-2-6-18-13-16(9-10-17(18)5-1)14-22-12-11-19-15-23-21-8-4-3-7-20(19)21/h1-10,13,15,22-23H,11-12,14H2
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 1.40E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50451494
PNG
(CHEMBL2113315)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)Cc1ccc2ccccc2c1 |wD:1.1,(7.16,-11.51,;7.16,-9.97,;8.68,-9.8,;9.45,-8.45,;10.97,-8.73,;11.93,-7.56,;13.38,-8.1,;13.66,-9.64,;14.55,-7.16,;5.83,-9.2,;4.5,-9.97,;5.83,-7.65,;7.16,-6.88,;7.16,-5.34,;8.5,-4.57,;9.9,-5.2,;10.94,-4.05,;10.17,-2.72,;10.65,-1.25,;9.62,-.1,;8.1,-.43,;7.63,-1.9,;8.66,-3.04,;4.5,-6.88,;3.16,-7.65,;3.14,-9.2,;1.81,-9.97,;.48,-9.2,;-.86,-9.97,;-2.19,-9.2,;-2.19,-7.65,;-.86,-6.88,;.48,-7.65,;1.81,-6.88,)|
Show InChI InChI=1S/C27H32N6O/c28-24(9-5-14-31-27(29)30)26(34)33(15-13-22-17-32-25-10-4-3-8-23(22)25)18-19-11-12-20-6-1-2-7-21(20)16-19/h1-4,6-8,10-12,16-17,24,32H,5,9,13-15,18,28H2,(H4,29,30,31)/t24-/m0/s1
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 1.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111160
PNG
(CHEMBL8045 | [2-(1H-Indol-3-yl)-ethyl]-naphthalen-...)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C21H20N2/c1-2-6-18-13-16(9-10-17(18)5-1)14-22-12-11-19-15-23-21-8-4-3-7-20(19)21/h1-10,13,15,22-23H,11-12,14H2
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 1.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111161
PNG
(CHEMBL269653 | [2-(1H-Indol-3-yl)-ethyl]-(1H-indol...)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1c[nH]c2ccccc12
Show InChI InChI=1S/C19H19N3/c1-3-7-18-16(5-1)14(12-21-18)9-10-20-11-15-13-22-19-8-4-2-6-17(15)19/h1-8,12-13,20-22H,9-11H2
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 1.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50451494
PNG
(CHEMBL2113315)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)Cc1ccc2ccccc2c1 |wD:1.1,(7.16,-11.51,;7.16,-9.97,;8.68,-9.8,;9.45,-8.45,;10.97,-8.73,;11.93,-7.56,;13.38,-8.1,;13.66,-9.64,;14.55,-7.16,;5.83,-9.2,;4.5,-9.97,;5.83,-7.65,;7.16,-6.88,;7.16,-5.34,;8.5,-4.57,;9.9,-5.2,;10.94,-4.05,;10.17,-2.72,;10.65,-1.25,;9.62,-.1,;8.1,-.43,;7.63,-1.9,;8.66,-3.04,;4.5,-6.88,;3.16,-7.65,;3.14,-9.2,;1.81,-9.97,;.48,-9.2,;-.86,-9.97,;-2.19,-9.2,;-2.19,-7.65,;-.86,-6.88,;.48,-7.65,;1.81,-6.88,)|
Show InChI InChI=1S/C27H32N6O/c28-24(9-5-14-31-27(29)30)26(34)33(15-13-22-17-32-25-10-4-3-8-23(22)25)18-19-11-12-20-6-1-2-7-21(20)16-19/h1-4,6-8,10-12,16-17,24,32H,5,9,13-15,18,28H2,(H4,29,30,31)/t24-/m0/s1
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 1.90E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111155
PNG
(CHEMBL269689 | N-{3-[(Naphthalen-2-ylmethyl)-amino...)
Show SMILES NC(=N)NCCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C15H20N4/c16-15(17)19-9-3-8-18-11-12-6-7-13-4-1-2-5-14(13)10-12/h1-2,4-7,10,18H,3,8-9,11H2,(H4,16,17,19)
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 1.90E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111172
PNG
(6-[(1H-Indol-3-ylmethyl)-amino]-2-[(naphthalen-2-y...)
Show SMILES NCCCCNC(=O)[C@H](CCCCNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C30H39N5O/c31-16-6-8-18-33-30(36)29(34-20-23-14-15-24-9-1-2-10-25(24)19-23)13-5-7-17-32-21-26-22-35-28-12-4-3-11-27(26)28/h1-4,9-12,14-15,19,22,29,32,34-35H,5-8,13,16-18,20-21,31H2,(H,33,36)/t29-/m0/s1
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 2.40E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111162
PNG
((1H-Indol-3-ylmethyl)-naphthalen-1-ylmethyl-amine ...)
Show SMILES C(NCc1cccc2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H18N2/c1-2-9-18-15(6-1)7-5-8-16(18)12-21-13-17-14-22-20-11-4-3-10-19(17)20/h1-11,14,21-22H,12-13H2
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 2.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111156
PNG
(CHEMBL269776 | N-(3-Amino-propyl)-3-[(1H-indol-3-y...)
Show SMILES NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H31N5O/c27-12-5-13-29-26(32)25(18-28-16-22-17-31-24-9-4-3-8-23(22)24)30-15-19-10-11-20-6-1-2-7-21(20)14-19/h1-4,6-11,14,17,25,28,30-31H,5,12-13,15-16,18,27H2,(H,29,32)/t25-/m0/s1
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 2.70E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111165
PNG
(CHEMBL266305 | N-(2-Amino-ethyl)-2,3-bis-[(naphtha...)
Show SMILES NCCNC(=O)[C@H](CNCc1ccc2ccccc2c1)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C27H30N4O/c28-13-14-30-27(32)26(31-18-21-10-12-23-6-2-4-8-25(23)16-21)19-29-17-20-9-11-22-5-1-3-7-24(22)15-20/h1-12,15-16,26,29,31H,13-14,17-19,28H2,(H,30,32)/t26-/m0/s1
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 2.70E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111165
PNG
(CHEMBL266305 | N-(2-Amino-ethyl)-2,3-bis-[(naphtha...)
Show SMILES NCCNC(=O)[C@H](CNCc1ccc2ccccc2c1)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C27H30N4O/c28-13-14-30-27(32)26(31-18-21-10-12-23-6-2-4-8-25(23)16-21)19-29-17-20-9-11-22-5-1-3-7-24(22)15-20/h1-12,15-16,26,29,31H,13-14,17-19,28H2,(H,30,32)/t26-/m0/s1
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 2.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111164
PNG
(CHEMBL8552 | N*1*-(1H-Indol-3-ylmethyl)-propane-1,...)
Show SMILES NCCCNCc1c[nH]c2ccccc12
Show InChI InChI=1S/C12H17N3/c13-6-3-7-14-8-10-9-15-12-5-2-1-4-11(10)12/h1-2,4-5,9,14-15H,3,6-8,13H2
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 2.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111155
PNG
(CHEMBL269689 | N-{3-[(Naphthalen-2-ylmethyl)-amino...)
Show SMILES NC(=N)NCCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C15H20N4/c16-15(17)19-9-3-8-18-11-12-6-7-13-4-1-2-5-14(13)10-12/h1-2,4-7,10,18H,3,8-9,11H2,(H4,16,17,19)
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 3.10E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111161
PNG
(CHEMBL269653 | [2-(1H-Indol-3-yl)-ethyl]-(1H-indol...)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1c[nH]c2ccccc12
Show InChI InChI=1S/C19H19N3/c1-3-7-18-16(5-1)14(12-21-18)9-10-20-11-15-13-22-19-8-4-2-6-17(15)19/h1-8,12-13,20-22H,9-11H2
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 3.20E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111173
PNG
(6-(3-Naphthalen-2-ylmethyl-3-naphthalen-1-ylmethyl...)
Show SMILES OC(=O)CCCCCNC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C29H30N2O3/c32-28(33)15-2-1-7-18-30-29(34)31(20-22-16-17-23-9-3-4-11-25(23)19-22)21-26-13-8-12-24-10-5-6-14-27(24)26/h3-6,8-14,16-17,19H,1-2,7,15,18,20-21H2,(H,30,34)(H,32,33)
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 3.30E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111156
PNG
(CHEMBL269776 | N-(3-Amino-propyl)-3-[(1H-indol-3-y...)
Show SMILES NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H31N5O/c27-12-5-13-29-26(32)25(18-28-16-22-17-31-24-9-4-3-8-23(22)24)30-15-19-10-11-20-6-1-2-7-21(20)14-19/h1-4,6-11,14,17,25,28,30-31H,5,12-13,15-16,18,27H2,(H,29,32)/t25-/m0/s1
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 3.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111155
PNG
(CHEMBL269689 | N-{3-[(Naphthalen-2-ylmethyl)-amino...)
Show SMILES NC(=N)NCCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C15H20N4/c16-15(17)19-9-3-8-18-11-12-6-7-13-4-1-2-5-14(13)10-12/h1-2,4-7,10,18H,3,8-9,11H2,(H4,16,17,19)
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 3.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111162
PNG
((1H-Indol-3-ylmethyl)-naphthalen-1-ylmethyl-amine ...)
Show SMILES C(NCc1cccc2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H18N2/c1-2-9-18-15(6-1)7-5-8-16(18)12-21-13-17-14-22-20-11-4-3-10-19(17)20/h1-11,14,21-22H,12-13H2
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 3.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111154
PNG
(CHEMBL8201 | N*1*-Naphthalen-2-ylmethyl-propane-1,...)
Show SMILES NCCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C14H18N2/c15-8-3-9-16-11-12-6-7-13-4-1-2-5-14(13)10-12/h1-2,4-7,10,16H,3,8-9,11,15H2
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 4.30E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111165
PNG
(CHEMBL266305 | N-(2-Amino-ethyl)-2,3-bis-[(naphtha...)
Show SMILES NCCNC(=O)[C@H](CNCc1ccc2ccccc2c1)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C27H30N4O/c28-13-14-30-27(32)26(31-18-21-10-12-23-6-2-4-8-25(23)16-21)19-29-17-20-9-11-22-5-1-3-7-24(22)15-20/h1-12,15-16,26,29,31H,13-14,17-19,28H2,(H,30,32)/t26-/m0/s1
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 4.40E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111169
PNG
(CHEMBL8742 | N-{3-[(1H-Indol-3-ylmethyl)-amino]-pr...)
Show SMILES NC(=N)NCCCNCc1c[nH]c2ccccc12
Show InChI InChI=1S/C13H19N5/c14-13(15)17-7-3-6-16-8-10-9-18-12-5-2-1-4-11(10)12/h1-2,4-5,9,16,18H,3,6-8H2,(H4,14,15,17)
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 4.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111157
PNG
((R)-4-Amino-4-(naphthalen-2-ylmethyl-naphthalen-1-...)
Show SMILES N[C@H](CCC(O)=O)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C27H26N2O3/c28-25(14-15-26(30)31)27(32)29(17-19-12-13-20-6-1-2-8-22(20)16-19)18-23-10-5-9-21-7-3-4-11-24(21)23/h1-13,16,25H,14-15,17-18,28H2,(H,30,31)/t25-/m1/s1
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 4.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111157
PNG
((R)-4-Amino-4-(naphthalen-2-ylmethyl-naphthalen-1-...)
Show SMILES N[C@H](CCC(O)=O)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C27H26N2O3/c28-25(14-15-26(30)31)27(32)29(17-19-12-13-20-6-1-2-8-22(20)16-19)18-23-10-5-9-21-7-3-4-11-24(21)23/h1-13,16,25H,14-15,17-18,28H2,(H,30,31)/t25-/m1/s1
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 4.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111169
PNG
(CHEMBL8742 | N-{3-[(1H-Indol-3-ylmethyl)-amino]-pr...)
Show SMILES NC(=N)NCCCNCc1c[nH]c2ccccc12
Show InChI InChI=1S/C13H19N5/c14-13(15)17-7-3-6-16-8-10-9-18-12-5-2-1-4-11(10)12/h1-2,4-5,9,16,18H,3,6-8H2,(H4,14,15,17)
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 4.70E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50451493
PNG
(CHEMBL2113280)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(Cc1c[nH]c2ccccc12)Cc1cccc2ccccc12 |wD:1.1,(9.22,-7.05,;9.22,-5.51,;10.74,-5.33,;11.51,-3.99,;13.02,-4.25,;13.98,-3.09,;15.43,-3.62,;15.71,-5.18,;16.59,-2.69,;7.89,-4.74,;6.56,-5.51,;7.89,-3.2,;6.56,-2.43,;5.23,-3.2,;5.05,-4.74,;3.55,-5.06,;2.8,-3.72,;1.29,-3.39,;.82,-1.92,;1.87,-.78,;3.37,-1.12,;3.83,-2.57,;9.22,-2.43,;9.22,-.89,;7.89,-.12,;7.89,1.42,;9.22,2.19,;10.55,1.42,;11.9,2.19,;13.23,1.42,;13.23,-.12,;11.9,-.89,;10.55,-.12,)|
Show InChI InChI=1S/C26H30N6O/c27-23(12-6-14-30-26(28)29)25(33)32(17-20-15-31-24-13-4-3-11-22(20)24)16-19-9-5-8-18-7-1-2-10-21(18)19/h1-5,7-11,13,15,23,31H,6,12,14,16-17,27H2,(H4,28,29,30)/t23-/m0/s1
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 5.20E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111156
PNG
(CHEMBL269776 | N-(3-Amino-propyl)-3-[(1H-indol-3-y...)
Show SMILES NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H31N5O/c27-12-5-13-29-26(32)25(18-28-16-22-17-31-24-9-4-3-8-23(22)24)30-15-19-10-11-20-6-1-2-7-21(20)14-19/h1-4,6-11,14,17,25,28,30-31H,5,12-13,15-16,18,27H2,(H,29,32)/t25-/m0/s1
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 5.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111155
PNG
(CHEMBL269689 | N-{3-[(Naphthalen-2-ylmethyl)-amino...)
Show SMILES NC(=N)NCCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C15H20N4/c16-15(17)19-9-3-8-18-11-12-6-7-13-4-1-2-5-14(13)10-12/h1-2,4-7,10,18H,3,8-9,11H2,(H4,16,17,19)
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 5.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111154
PNG
(CHEMBL8201 | N*1*-Naphthalen-2-ylmethyl-propane-1,...)
Show SMILES NCCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C14H18N2/c15-8-3-9-16-11-12-6-7-13-4-1-2-5-14(13)10-12/h1-2,4-7,10,16H,3,8-9,11,15H2
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 5.70E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111165
PNG
(CHEMBL266305 | N-(2-Amino-ethyl)-2,3-bis-[(naphtha...)
Show SMILES NCCNC(=O)[C@H](CNCc1ccc2ccccc2c1)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C27H30N4O/c28-13-14-30-27(32)26(31-18-21-10-12-23-6-2-4-8-25(23)16-21)19-29-17-20-9-11-22-5-1-3-7-24(22)15-20/h1-12,15-16,26,29,31H,13-14,17-19,28H2,(H,30,32)/t26-/m0/s1
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 5.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111160
PNG
(CHEMBL8045 | [2-(1H-Indol-3-yl)-ethyl]-naphthalen-...)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C21H20N2/c1-2-6-18-13-16(9-10-17(18)5-1)14-22-12-11-19-15-23-21-8-4-3-7-20(19)21/h1-10,13,15,22-23H,11-12,14H2
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 5.90E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111168
PNG
(4-Naphthalen-2-ylmethyl-piperazine-1-carboxamidine...)
Show SMILES NC(=N)N1CCN(Cc2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C16H20N4/c17-16(18)20-9-7-19(8-10-20)12-13-5-6-14-3-1-2-4-15(14)11-13/h1-6,11H,7-10,12H2,(H3,17,18)
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 6.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50451493
PNG
(CHEMBL2113280)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(Cc1c[nH]c2ccccc12)Cc1cccc2ccccc12 |wD:1.1,(9.22,-7.05,;9.22,-5.51,;10.74,-5.33,;11.51,-3.99,;13.02,-4.25,;13.98,-3.09,;15.43,-3.62,;15.71,-5.18,;16.59,-2.69,;7.89,-4.74,;6.56,-5.51,;7.89,-3.2,;6.56,-2.43,;5.23,-3.2,;5.05,-4.74,;3.55,-5.06,;2.8,-3.72,;1.29,-3.39,;.82,-1.92,;1.87,-.78,;3.37,-1.12,;3.83,-2.57,;9.22,-2.43,;9.22,-.89,;7.89,-.12,;7.89,1.42,;9.22,2.19,;10.55,1.42,;11.9,2.19,;13.23,1.42,;13.23,-.12,;11.9,-.89,;10.55,-.12,)|
Show InChI InChI=1S/C26H30N6O/c27-23(12-6-14-30-26(28)29)25(33)32(17-20-15-31-24-13-4-3-11-22(20)24)16-19-9-5-8-18-7-1-2-10-21(18)19/h1-5,7-11,13,15,23,31H,6,12,14,16-17,27H2,(H4,28,29,30)/t23-/m0/s1
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 7.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111168
PNG
(4-Naphthalen-2-ylmethyl-piperazine-1-carboxamidine...)
Show SMILES NC(=N)N1CCN(Cc2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C16H20N4/c17-16(18)20-9-7-19(8-10-20)12-13-5-6-14-3-1-2-4-15(14)11-13/h1-6,11H,7-10,12H2,(H3,17,18)
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 7.40E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111174
PNG
(CHEMBL8743 | N*1*-Naphthalen-2-ylmethyl-ethane-1,2...)
Show SMILES NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C13H16N2/c14-7-8-15-10-11-5-6-12-3-1-2-4-13(12)9-11/h1-6,9,15H,7-8,10,14H2
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 8.30E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111161
PNG
(CHEMBL269653 | [2-(1H-Indol-3-yl)-ethyl]-(1H-indol...)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1c[nH]c2ccccc12
Show InChI InChI=1S/C19H19N3/c1-3-7-18-16(5-1)14(12-21-18)9-10-20-11-15-13-22-19-8-4-2-6-17(15)19/h1-8,12-13,20-22H,9-11H2
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 8.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111157
PNG
((R)-4-Amino-4-(naphthalen-2-ylmethyl-naphthalen-1-...)
Show SMILES N[C@H](CCC(O)=O)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C27H26N2O3/c28-25(14-15-26(30)31)27(32)29(17-19-12-13-20-6-1-2-8-22(20)16-19)18-23-10-5-9-21-7-3-4-11-24(21)23/h1-13,16,25H,14-15,17-18,28H2,(H,30,31)/t25-/m1/s1
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 8.90E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111154
PNG
(CHEMBL8201 | N*1*-Naphthalen-2-ylmethyl-propane-1,...)
Show SMILES NCCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C14H18N2/c15-8-3-9-16-11-12-6-7-13-4-1-2-5-14(13)10-12/h1-2,4-7,10,16H,3,8-9,11,15H2
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 9.40E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111163
PNG
(CHEMBL8129 | Naphthalen-2-ylmethyl-naphthalen-1-yl...)
Show SMILES C(NCc1cccc2ccccc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H19N/c1-2-8-20-14-17(12-13-18(20)6-1)15-23-16-21-10-5-9-19-7-3-4-11-22(19)21/h1-14,23H,15-16H2
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 1.00E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111164
PNG
(CHEMBL8552 | N*1*-(1H-Indol-3-ylmethyl)-propane-1,...)
Show SMILES NCCCNCc1c[nH]c2ccccc12
Show InChI InChI=1S/C12H17N3/c13-6-3-7-14-8-10-9-15-12-5-2-1-4-11(10)12/h1-2,4-5,9,14-15H,3,6-8,13H2
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 1.04E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111169
PNG
(CHEMBL8742 | N-{3-[(1H-Indol-3-ylmethyl)-amino]-pr...)
Show SMILES NC(=N)NCCCNCc1c[nH]c2ccccc12
Show InChI InChI=1S/C13H19N5/c14-13(15)17-7-3-6-16-8-10-9-18-12-5-2-1-4-11(10)12/h1-2,4-5,9,16,18H,3,6-8H2,(H4,14,15,17)
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 1.07E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111160
PNG
(CHEMBL8045 | [2-(1H-Indol-3-yl)-ethyl]-naphthalen-...)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C21H20N2/c1-2-6-18-13-16(9-10-17(18)5-1)14-22-12-11-19-15-23-21-8-4-3-7-20(19)21/h1-10,13,15,22-23H,11-12,14H2
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 1.18E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111166
PNG
(1-Naphthalen-2-ylmethyl-piperazine | CHEMBL8756)
Show SMILES C(N1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2/c1-2-4-15-11-13(5-6-14(15)3-1)12-17-9-7-16-8-10-17/h1-6,11,16H,7-10,12H2
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 1.41E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111164
PNG
(CHEMBL8552 | N*1*-(1H-Indol-3-ylmethyl)-propane-1,...)
Show SMILES NCCCNCc1c[nH]c2ccccc12
Show InChI InChI=1S/C12H17N3/c13-6-3-7-14-8-10-9-15-12-5-2-1-4-11(10)12/h1-2,4-5,9,14-15H,3,6-8,13H2
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 1.45E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111164
PNG
(CHEMBL8552 | N*1*-(1H-Indol-3-ylmethyl)-propane-1,...)
Show SMILES NCCCNCc1c[nH]c2ccccc12
Show InChI InChI=1S/C12H17N3/c13-6-3-7-14-8-10-9-15-12-5-2-1-4-11(10)12/h1-2,4-5,9,14-15H,3,6-8,13H2
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 1.50E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111161
PNG
(CHEMBL269653 | [2-(1H-Indol-3-yl)-ethyl]-(1H-indol...)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1c[nH]c2ccccc12
Show InChI InChI=1S/C19H19N3/c1-3-7-18-16(5-1)14(12-21-18)9-10-20-11-15-13-22-19-8-4-2-6-17(15)19/h1-8,12-13,20-22H,9-11H2
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 1.61E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111162
PNG
((1H-Indol-3-ylmethyl)-naphthalen-1-ylmethyl-amine ...)
Show SMILES C(NCc1cccc2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H18N2/c1-2-9-18-15(6-1)7-5-8-16(18)12-21-13-17-14-22-20-11-4-3-10-19(17)20/h1-11,14,21-22H,12-13H2
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 1.61E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111172
PNG
(6-[(1H-Indol-3-ylmethyl)-amino]-2-[(naphthalen-2-y...)
Show SMILES NCCCCNC(=O)[C@H](CCCCNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C30H39N5O/c31-16-6-8-18-33-30(36)29(34-20-23-14-15-24-9-1-2-10-25(24)19-23)13-5-7-17-32-21-26-22-35-28-12-4-3-11-27(26)28/h1-4,9-12,14-15,19,22,29,32,34-35H,5-8,13,16-18,20-21,31H2,(H,33,36)/t29-/m0/s1
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 1.67E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111172
PNG
(6-[(1H-Indol-3-ylmethyl)-amino]-2-[(naphthalen-2-y...)
Show SMILES NCCCCNC(=O)[C@H](CCCCNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1
Show InChI InChI=1S/C30H39N5O/c31-16-6-8-18-33-30(36)29(34-20-23-14-15-24-9-1-2-10-25(24)19-23)13-5-7-17-32-21-26-22-35-28-12-4-3-11-27(26)28/h1-4,9-12,14-15,19,22,29,32,34-35H,5-8,13,16-18,20-21,31H2,(H,33,36)/t29-/m0/s1
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 1.73E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111162
PNG
((1H-Indol-3-ylmethyl)-naphthalen-1-ylmethyl-amine ...)
Show SMILES C(NCc1cccc2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H18N2/c1-2-9-18-15(6-1)7-5-8-16(18)12-21-13-17-14-22-20-11-4-3-10-19(17)20/h1-11,14,21-22H,12-13H2
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 2.14E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111159
PNG
(3-Piperazin-1-ylmethyl-1H-indole | CHEMBL276397)
Show SMILES C(N1CCNCC1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C13H17N3/c1-2-4-13-12(3-1)11(9-15-13)10-16-7-5-14-6-8-16/h1-4,9,14-15H,5-8,10H2
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 2.56E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111157
PNG
((R)-4-Amino-4-(naphthalen-2-ylmethyl-naphthalen-1-...)
Show SMILES N[C@H](CCC(O)=O)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C27H26N2O3/c28-25(14-15-26(30)31)27(32)29(17-19-12-13-20-6-1-2-8-22(20)16-19)18-23-10-5-9-21-7-3-4-11-24(21)23/h1-13,16,25H,14-15,17-18,28H2,(H,30,31)/t25-/m1/s1
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 2.94E+5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111163
PNG
(CHEMBL8129 | Naphthalen-2-ylmethyl-naphthalen-1-yl...)
Show SMILES C(NCc1cccc2ccccc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H19N/c1-2-8-20-14-17(12-13-18(20)6-1)15-23-16-21-10-5-9-19-7-3-4-11-22(19)21/h1-14,23H,15-16H2
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Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111168
PNG
(4-Naphthalen-2-ylmethyl-piperazine-1-carboxamidine...)
Show SMILES NC(=N)N1CCN(Cc2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C16H20N4/c17-16(18)20-9-7-19(8-10-20)12-13-5-6-14-3-1-2-4-15(14)11-13/h1-6,11H,7-10,12H2,(H3,17,18)
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111166
PNG
(1-Naphthalen-2-ylmethyl-piperazine | CHEMBL8756)
Show SMILES C(N1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2/c1-2-4-15-11-13(5-6-14(15)3-1)12-17-9-7-16-8-10-17/h1-6,11,16H,7-10,12H2
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Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111159
PNG
(3-Piperazin-1-ylmethyl-1H-indole | CHEMBL276397)
Show SMILES C(N1CCNCC1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C13H17N3/c1-2-4-13-12(3-1)11(9-15-13)10-16-7-5-14-6-8-16/h1-4,9,14-15H,5-8,10H2
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Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111171
PNG
(4-(1H-Indol-3-ylmethyl)-piperazine-1-carboxamidine...)
Show SMILES NC(=N)N1CCN(Cc2c[nH]c3ccccc23)CC1
Show InChI InChI=1S/C14H19N5/c15-14(16)19-7-5-18(6-8-19)10-11-9-17-13-4-2-1-3-12(11)13/h1-4,9,17H,5-8,10H2,(H3,15,16)
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Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111166
PNG
(1-Naphthalen-2-ylmethyl-piperazine | CHEMBL8756)
Show SMILES C(N1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2/c1-2-4-15-11-13(5-6-14(15)3-1)12-17-9-7-16-8-10-17/h1-6,11,16H,7-10,12H2
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Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50111171
PNG
(4-(1H-Indol-3-ylmethyl)-piperazine-1-carboxamidine...)
Show SMILES NC(=N)N1CCN(Cc2c[nH]c3ccccc23)CC1
Show InChI InChI=1S/C14H19N5/c15-14(16)19-7-5-18(6-8-19)10-11-9-17-13-4-2-1-3-12(11)13/h1-4,9,17H,5-8,10H2,(H3,15,16)
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Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 4 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50111171
PNG
(4-(1H-Indol-3-ylmethyl)-piperazine-1-carboxamidine...)
Show SMILES NC(=N)N1CCN(Cc2c[nH]c3ccccc23)CC1
Show InChI InChI=1S/C14H19N5/c15-14(16)19-7-5-18(6-8-19)10-11-9-17-13-4-2-1-3-12(11)13/h1-4,9,17H,5-8,10H2,(H3,15,16)
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 5 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111171
PNG
(4-(1H-Indol-3-ylmethyl)-piperazine-1-carboxamidine...)
Show SMILES NC(=N)N1CCN(Cc2c[nH]c3ccccc23)CC1
Show InChI InChI=1S/C14H19N5/c15-14(16)19-7-5-18(6-8-19)10-11-9-17-13-4-2-1-3-12(11)13/h1-4,9,17H,5-8,10H2,(H3,15,16)
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111159
PNG
(3-Piperazin-1-ylmethyl-1H-indole | CHEMBL276397)
Show SMILES C(N1CCNCC1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C13H17N3/c1-2-4-13-12(3-1)11(9-15-13)10-16-7-5-14-6-8-16/h1-4,9,14-15H,5-8,10H2
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111166
PNG
(1-Naphthalen-2-ylmethyl-piperazine | CHEMBL8756)
Show SMILES C(N1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2/c1-2-4-15-11-13(5-6-14(15)3-1)12-17-9-7-16-8-10-17/h1-6,11,16H,7-10,12H2
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111154
PNG
(CHEMBL8201 | N*1*-Naphthalen-2-ylmethyl-propane-1,...)
Show SMILES NCCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C14H18N2/c15-8-3-9-16-11-12-6-7-13-4-1-2-5-14(13)10-12/h1-2,4-7,10,16H,3,8-9,11,15H2
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50111163
PNG
(CHEMBL8129 | Naphthalen-2-ylmethyl-naphthalen-1-yl...)
Show SMILES C(NCc1cccc2ccccc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H19N/c1-2-8-20-14-17(12-13-18(20)6-1)15-23-16-21-10-5-9-19-7-3-4-11-22(19)21/h1-14,23H,15-16H2
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 1 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111168
PNG
(4-Naphthalen-2-ylmethyl-piperazine-1-carboxamidine...)
Show SMILES NC(=N)N1CCN(Cc2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C16H20N4/c17-16(18)20-9-7-19(8-10-20)12-13-5-6-14-3-1-2-4-15(14)11-13/h1-6,11H,7-10,12H2,(H3,17,18)
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111163
PNG
(CHEMBL8129 | Naphthalen-2-ylmethyl-naphthalen-1-yl...)
Show SMILES C(NCc1cccc2ccccc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H19N/c1-2-8-20-14-17(12-13-18(20)6-1)15-23-16-21-10-5-9-19-7-3-4-11-22(19)21/h1-14,23H,15-16H2
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50111159
PNG
(3-Piperazin-1-ylmethyl-1H-indole | CHEMBL276397)
Show SMILES C(N1CCNCC1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C13H17N3/c1-2-4-13-12(3-1)11(9-15-13)10-16-7-5-14-6-8-16/h1-4,9,14-15H,5-8,10H2
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>1.00E+6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay

Bioorg Med Chem Lett 12: 1035-8 (2002)


BindingDB Entry DOI: 10.7270/Q2D799RR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%