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PubMed code 11958997

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50112002
PNG
(CHEMBL176993 | N-Hydroxy-N'-[2-(hydroxyaminooxalyl...)
Show SMILES ONC(=O)C(=O)NCCN(C(=O)C(=O)NO)c1cccc2ccccc12
Show InChI InChI=1S/C16H16N4O6/c21-13(14(22)18-25)17-8-9-20(16(24)15(23)19-26)12-7-3-5-10-4-1-2-6-11(10)12/h1-7,25-26H,8-9H2,(H,17,21)(H,18,22)(H,19,23)
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 100n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50112003
PNG
(CHEMBL435713 | N-Hydroxy-N'-[(S)-2-(1H-indol-3-yl)...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C21H22N4O4/c1-13(14-7-3-2-4-8-14)23-19(26)18(24-20(27)21(28)25-29)11-15-12-22-17-10-6-5-9-16(15)17/h2-10,12-13,18,22,29H,11H2,1H3,(H,23,26)(H,24,27)(H,25,28)/t13-,18-/m0/s1
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 100n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50112004
PNG
(CHEMBL171466 | N-Hydroxy-N'-[(S)-2-naphthalen-1-yl...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C23H23N3O4/c1-15(16-8-3-2-4-9-16)24-21(27)20(25-22(28)23(29)26-30)14-18-12-7-11-17-10-5-6-13-19(17)18/h2-13,15,20,30H,14H2,1H3,(H,24,27)(H,25,28)(H,26,29)/t15-,20-/m0/s1
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 150n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111984
PNG
(CHEMBL174865 | N-Hydroxy-N'-[(S)-2-(4-hydroxy-phen...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C19H21N3O5/c1-12(14-5-3-2-4-6-14)20-17(24)16(21-18(25)19(26)22-27)11-13-7-9-15(23)10-8-13/h2-10,12,16,23,27H,11H2,1H3,(H,20,24)(H,21,25)(H,22,26)/t12-,16-/m0/s1
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 250n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111999
PNG
(CHEMBL172874 | N-[3-(2-Ethyl-hexyloxy)-propyl]-N'-...)
Show SMILES CCCCC(CC)COCCCNC(=O)C(=O)NO
Show InChI InChI=1S/C13H26N2O4/c1-3-5-7-11(4-2)10-19-9-6-8-14-12(16)13(17)15-18/h11,18H,3-10H2,1-2H3,(H,14,16)(H,15,17)
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 250n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50112004
PNG
(CHEMBL171466 | N-Hydroxy-N'-[(S)-2-naphthalen-1-yl...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C23H23N3O4/c1-15(16-8-3-2-4-9-16)24-21(27)20(25-22(28)23(29)26-30)14-18-12-7-11-17-10-5-6-13-19(17)18/h2-13,15,20,30H,14H2,1H3,(H,24,27)(H,25,28)(H,26,29)/t15-,20-/m0/s1
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 300n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111996
PNG
(CHEMBL173382 | N-[2-(5-Chloro-1H-indol-3-yl)-ethyl...)
Show SMILES ONC(=O)C(=O)NCCc1c[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C12H12ClN3O3/c13-8-1-2-10-9(5-8)7(6-15-10)3-4-14-11(17)12(18)16-19/h1-2,5-6,15,19H,3-4H2,(H,14,17)(H,16,18)
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 350n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50112003
PNG
(CHEMBL435713 | N-Hydroxy-N'-[(S)-2-(1H-indol-3-yl)...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C21H22N4O4/c1-13(14-7-3-2-4-8-14)23-19(26)18(24-20(27)21(28)25-29)11-15-12-22-17-10-6-5-9-16(15)17/h2-10,12-13,18,22,29H,11H2,1H3,(H,23,26)(H,24,27)(H,25,28)/t13-,18-/m0/s1
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 400n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111995
PNG
(CHEMBL369184 | N-Hydroxy-N'-[(S)-2-phenyl-1-((S)-1...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C19H21N3O4/c1-13(15-10-6-3-7-11-15)20-17(23)16(21-18(24)19(25)22-26)12-14-8-4-2-5-9-14/h2-11,13,16,26H,12H2,1H3,(H,20,23)(H,21,24)(H,22,25)/t13-,16-/m0/s1
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 430n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111989
PNG
(CHEMBL172180 | N-Hydroxy-N'-[(S)-2-naphthalen-2-yl...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C23H23N3O4/c1-15(17-7-3-2-4-8-17)24-21(27)20(25-22(28)23(29)26-30)14-16-11-12-18-9-5-6-10-19(18)13-16/h2-13,15,20,30H,14H2,1H3,(H,24,27)(H,25,28)(H,26,29)/t15-,20-/m0/s1
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 500n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111984
PNG
(CHEMBL174865 | N-Hydroxy-N'-[(S)-2-(4-hydroxy-phen...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C19H21N3O5/c1-12(14-5-3-2-4-6-14)20-17(24)16(21-18(25)19(26)22-27)11-13-7-9-15(23)10-8-13/h2-10,12,16,23,27H,11H2,1H3,(H,20,24)(H,21,25)(H,22,26)/t12-,16-/m0/s1
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 600n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50112000
PNG
((S)-3-(Hydroxyaminooxalyl-amino)-N-((S)-1-phenyl-e...)
Show SMILES C[C@H](NC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C21H23N3O6/c1-14(16-10-6-3-7-11-16)22-19(26)17(23-20(27)21(28)24-29)12-18(25)30-13-15-8-4-2-5-9-15/h2-11,14,17,29H,12-13H2,1H3,(H,22,26)(H,23,27)(H,24,28)/t14-,17-/m0/s1
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 600n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50112007
PNG
(CHEMBL171949 | N-Hydroxy-N'-[2-(1H-indol-3-yl)-eth...)
Show SMILES ONC(=O)C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C12H13N3O3/c16-11(12(17)15-18)13-6-5-8-7-14-10-4-2-1-3-9(8)10/h1-4,7,14,18H,5-6H2,(H,13,16)(H,15,17)
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 800n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111990
PNG
(CHEMBL170103 | N-Hydroxy-N'-{(S)-1-((S)-1-phenyl-e...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(NC(=O)Nc2ccccc2)cc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C26H27N5O5/c1-17(19-8-4-2-5-9-19)27-23(32)22(30-24(33)25(34)31-36)16-18-12-14-21(15-13-18)29-26(35)28-20-10-6-3-7-11-20/h2-15,17,22,36H,16H2,1H3,(H,27,32)(H,30,33)(H,31,34)(H2,28,29,35)/t17-,22-/m0/s1
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 800n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111995
PNG
(CHEMBL369184 | N-Hydroxy-N'-[(S)-2-phenyl-1-((S)-1...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C19H21N3O4/c1-13(15-10-6-3-7-11-15)20-17(23)16(21-18(24)19(25)22-26)12-14-8-4-2-5-9-14/h2-11,13,16,26H,12H2,1H3,(H,20,23)(H,21,24)(H,22,25)/t13-,16-/m0/s1
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 900n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111989
PNG
(CHEMBL172180 | N-Hydroxy-N'-[(S)-2-naphthalen-2-yl...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C23H23N3O4/c1-15(17-7-3-2-4-8-17)24-21(27)20(25-22(28)23(29)26-30)14-16-11-12-18-9-5-6-10-19(18)13-16/h2-13,15,20,30H,14H2,1H3,(H,24,27)(H,25,28)(H,26,29)/t15-,20-/m0/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111992
PNG
(CHEMBL173533 | N-{(S)-1-[(R)-2-(4-Benzyloxy-phenyl...)
Show SMILES CN(C)C(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C29H32N4O6/c1-33(2)29(37)25(18-21-13-15-23(16-14-21)39-19-22-11-7-4-8-12-22)31-26(34)24(30-27(35)28(36)32-38)17-20-9-5-3-6-10-20/h3-16,24-25,38H,17-19H2,1-2H3,(H,30,35)(H,31,34)(H,32,36)/t24-,25+/m0/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111990
PNG
(CHEMBL170103 | N-Hydroxy-N'-{(S)-1-((S)-1-phenyl-e...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(NC(=O)Nc2ccccc2)cc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C26H27N5O5/c1-17(19-8-4-2-5-9-19)27-23(32)22(30-24(33)25(34)31-36)16-18-12-14-21(15-13-18)29-26(35)28-20-10-6-3-7-11-20/h2-15,17,22,36H,16H2,1H3,(H,27,32)(H,30,33)(H,31,34)(H2,28,29,35)/t17-,22-/m0/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50111992
PNG
(CHEMBL173533 | N-{(S)-1-[(R)-2-(4-Benzyloxy-phenyl...)
Show SMILES CN(C)C(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C29H32N4O6/c1-33(2)29(37)25(18-21-13-15-23(16-14-21)39-19-22-11-7-4-8-12-22)31-26(34)24(30-27(35)28(36)32-38)17-20-9-5-3-6-10-20/h3-16,24-25,38H,17-19H2,1-2H3,(H,30,35)(H,31,34)(H,32,36)/t24-,25+/m0/s1
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 1.40E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111997
PNG
(CHEMBL366997 | N-[(S)-2-(4-Benzyloxy-phenyl)-1-met...)
Show SMILES CNC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C19H21N3O5/c1-20-17(23)16(21-18(24)19(25)22-26)11-13-7-9-15(10-8-13)27-12-14-5-3-2-4-6-14/h2-10,16,26H,11-12H2,1H3,(H,20,23)(H,21,24)(H,22,25)/t16-/m0/s1
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 1.50E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50112006
PNG
(CHEMBL367959 | N-Hydroxy-N'-[(S)-3-methyl-1-((S)-1...)
Show SMILES CC(C)C[C@H](NC(=O)C(=O)NO)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C16H23N3O4/c1-10(2)9-13(18-15(21)16(22)19-23)14(20)17-11(3)12-7-5-4-6-8-12/h4-8,10-11,13,23H,9H2,1-3H3,(H,17,20)(H,18,21)(H,19,22)/t11-,13-/m0/s1
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 1.70E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111997
PNG
(CHEMBL366997 | N-[(S)-2-(4-Benzyloxy-phenyl)-1-met...)
Show SMILES CNC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C19H21N3O5/c1-20-17(23)16(21-18(24)19(25)22-26)11-13-7-9-15(10-8-13)27-12-14-5-3-2-4-6-14/h2-10,16,26H,11-12H2,1H3,(H,20,23)(H,21,24)(H,22,25)/t16-/m0/s1
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 2.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111988
PNG
(CHEMBL368180 | N-[(S)-2-Benzyloxy-1-((S)-1-phenyl-...)
Show SMILES CC(OCc1ccccc1)[C@H](NC(=O)C(=O)NO)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C21H25N3O5/c1-14(17-11-7-4-8-12-17)22-19(25)18(23-20(26)21(27)24-28)15(2)29-13-16-9-5-3-6-10-16/h3-12,14-15,18,28H,13H2,1-2H3,(H,22,25)(H,23,26)(H,24,27)/t14-,15?,18-/m0/s1
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 3.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111998
PNG
(CHEMBL174993 | N-[(S)-1-Dimethylcarbamoyl-2-(4-phe...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccc(COc2ccccc2)cc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C20H23N3O5/c1-23(2)20(26)17(21-18(24)19(25)22-27)12-14-8-10-15(11-9-14)13-28-16-6-4-3-5-7-16/h3-11,17,27H,12-13H2,1-2H3,(H,21,24)(H,22,25)/t17-/m0/s1
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 3.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111988
PNG
(CHEMBL368180 | N-[(S)-2-Benzyloxy-1-((S)-1-phenyl-...)
Show SMILES CC(OCc1ccccc1)[C@H](NC(=O)C(=O)NO)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C21H25N3O5/c1-14(17-11-7-4-8-12-17)22-19(25)18(23-20(26)21(27)24-28)15(2)29-13-16-9-5-3-6-10-16/h3-12,14-15,18,28H,13H2,1-2H3,(H,22,25)(H,23,26)(H,24,27)/t14-,15?,18-/m0/s1
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 3.20E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111991
PNG
(CHEMBL174422 | N-[(S)-2-Benzyloxy-1-((S)-1-phenyl-...)
Show SMILES C[C@H](NC(=O)[C@H](COCc1ccccc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C20H23N3O5/c1-14(16-10-6-3-7-11-16)21-18(24)17(22-19(25)20(26)23-27)13-28-12-15-8-4-2-5-9-15/h2-11,14,17,27H,12-13H2,1H3,(H,21,24)(H,22,25)(H,23,26)/t14-,17-/m0/s1
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 3.30E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111994
PNG
(CHEMBL369419 | N-Hydroxy-N'-((R)-1-naphthalen-2-yl...)
Show SMILES C[C@@H](NC(=O)C(=O)NO)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H14N2O3/c1-9(15-13(17)14(18)16-19)11-7-6-10-4-2-3-5-12(10)8-11/h2-9,19H,1H3,(H,15,17)(H,16,18)/t9-/m1/s1
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 3.30E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111985
PNG
(CHEMBL367331 | N-((S)-2-Benzyloxy-1-dimethylcarbam...)
Show SMILES CC(OCc1ccccc1)[C@H](NC(=O)C(=O)NO)C(=O)N(C)C
Show InChI InChI=1S/C15H21N3O5/c1-10(23-9-11-7-5-4-6-8-11)12(15(21)18(2)3)16-13(19)14(20)17-22/h4-8,10,12,22H,9H2,1-3H3,(H,16,19)(H,17,20)/t10?,12-/m0/s1
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 4.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111993
PNG
(CHEMBL174373 | N-[(S)-1-Dimethylcarbamoyl-2-(1H-in...)
Show SMILES CN(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(=O)NO
Show InChI InChI=1S/C15H18N4O4/c1-19(2)15(22)12(17-13(20)14(21)18-23)7-9-8-16-11-6-4-3-5-10(9)11/h3-6,8,12,16,23H,7H2,1-2H3,(H,17,20)(H,18,21)/t12-/m0/s1
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 4.40E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50112006
PNG
(CHEMBL367959 | N-Hydroxy-N'-[(S)-3-methyl-1-((S)-1...)
Show SMILES CC(C)C[C@H](NC(=O)C(=O)NO)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C16H23N3O4/c1-10(2)9-13(18-15(21)16(22)19-23)14(20)17-11(3)12-7-5-4-6-8-12/h4-8,10-11,13,23H,9H2,1-3H3,(H,17,20)(H,18,21)(H,19,22)/t11-,13-/m0/s1
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 5.50E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50112001
PNG
(CHEMBL355727 | N-Hydroxy-N'-[(S)-1-((S)-1-phenyl-e...)
Show SMILES C[C@H](NC(=O)C(=O)NO)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C13H17N3O4/c1-8(10-6-4-3-5-7-10)14-11(17)9(2)15-12(18)13(19)16-20/h3-9,20H,1-2H3,(H,14,17)(H,15,18)(H,16,19)/t8-,9-/m0/s1
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 6.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111987
PNG
(CHEMBL177048 | N-((S)-1-Dimethylcarbamoyl-2-naphth...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C(=O)NO
Show InChI InChI=1S/C17H19N3O4/c1-20(2)17(23)14(18-15(21)16(22)19-24)10-11-7-8-12-5-3-4-6-13(12)9-11/h3-9,14,24H,10H2,1-2H3,(H,18,21)(H,19,22)/t14-/m0/s1
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 6.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111999
PNG
(CHEMBL172874 | N-[3-(2-Ethyl-hexyloxy)-propyl]-N'-...)
Show SMILES CCCCC(CC)COCCCNC(=O)C(=O)NO
Show InChI InChI=1S/C13H26N2O4/c1-3-5-7-11(4-2)10-19-9-6-8-14-12(16)13(17)15-18/h11,18H,3-10H2,1-2H3,(H,14,16)(H,15,17)
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 7.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111983
PNG
(CHEMBL367722 | N-{(S)-1-[(R)-2-(4-Benzyloxy-phenyl...)
Show SMILES CCCC[C@H](NC(=O)C(=O)NO)C(=O)N[C@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N(C)C
Show InChI InChI=1S/C26H34N4O6/c1-4-5-11-21(27-24(32)25(33)29-35)23(31)28-22(26(34)30(2)3)16-18-12-14-20(15-13-18)36-17-19-9-7-6-8-10-19/h6-10,12-15,21-22,35H,4-5,11,16-17H2,1-3H3,(H,27,32)(H,28,31)(H,29,33)/t21-,22+/m0/s1
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 7.50E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111986
PNG
(CHEMBL174084 | N-((S)-1-Dimethylcarbamoyl-2-naphth...)
Show SMILES CN(C)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(=O)NO
Show InChI InChI=1S/C17H19N3O4/c1-20(2)17(23)14(18-15(21)16(22)19-24)10-12-8-5-7-11-6-3-4-9-13(11)12/h3-9,14,24H,10H2,1-2H3,(H,18,21)(H,19,22)/t14-/m0/s1
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 8.20E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50112001
PNG
(CHEMBL355727 | N-Hydroxy-N'-[(S)-1-((S)-1-phenyl-e...)
Show SMILES C[C@H](NC(=O)C(=O)NO)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C13H17N3O4/c1-8(10-6-4-3-5-7-10)14-11(17)9(2)15-12(18)13(19)16-20/h3-9,20H,1-2H3,(H,14,17)(H,15,18)(H,16,19)/t8-,9-/m0/s1
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 9.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50111999
PNG
(CHEMBL172874 | N-[3-(2-Ethyl-hexyloxy)-propyl]-N'-...)
Show SMILES CCCCC(CC)COCCCNC(=O)C(=O)NO
Show InChI InChI=1S/C13H26N2O4/c1-3-5-7-11(4-2)10-19-9-6-8-14-12(16)13(17)15-18/h11,18H,3-10H2,1-2H3,(H,14,16)(H,15,17)
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 9.00E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50112005
PNG
(CHEMBL355756 | N-((S)-1-Dimethylcarbamoyl-2-phenyl...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C13H17N3O4/c1-16(2)13(19)10(14-11(17)12(18)15-20)8-9-6-4-3-5-7-9/h3-7,10,20H,8H2,1-2H3,(H,14,17)(H,15,18)/t10-/m0/s1
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 9.50E+3n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50111991
PNG
(CHEMBL174422 | N-[(S)-2-Benzyloxy-1-((S)-1-phenyl-...)
Show SMILES C[C@H](NC(=O)[C@H](COCc1ccccc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C20H23N3O5/c1-14(16-10-6-3-7-11-16)21-18(24)17(22-19(25)20(26)23-27)13-28-12-15-8-4-2-5-9-15/h2-11,14,17,27H,12-13H2,1H3,(H,21,24)(H,22,25)(H,23,26)/t14-,17-/m0/s1
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 1.10E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111996
PNG
(CHEMBL173382 | N-[2-(5-Chloro-1H-indol-3-yl)-ethyl...)
Show SMILES ONC(=O)C(=O)NCCc1c[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C12H12ClN3O3/c13-8-1-2-10-9(5-8)7(6-15-10)3-4-14-11(17)12(18)16-19/h1-2,5-6,15,19H,3-4H2,(H,14,17)(H,16,18)
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 1.40E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50112005
PNG
(CHEMBL355756 | N-((S)-1-Dimethylcarbamoyl-2-phenyl...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C13H17N3O4/c1-16(2)13(19)10(14-11(17)12(18)15-20)8-9-6-4-3-5-7-9/h3-7,10,20H,8H2,1-2H3,(H,14,17)(H,15,18)/t10-/m0/s1
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 1.40E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50111995
PNG
(CHEMBL369184 | N-Hydroxy-N'-[(S)-2-phenyl-1-((S)-1...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C19H21N3O4/c1-13(15-10-6-3-7-11-15)20-17(23)16(21-18(24)19(25)22-26)12-14-8-4-2-5-9-14/h2-11,13,16,26H,12H2,1H3,(H,20,23)(H,21,24)(H,22,25)/t13-,16-/m0/s1
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 1.40E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50111993
PNG
(CHEMBL174373 | N-[(S)-1-Dimethylcarbamoyl-2-(1H-in...)
Show SMILES CN(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(=O)NO
Show InChI InChI=1S/C15H18N4O4/c1-19(2)15(22)12(17-13(20)14(21)18-23)7-9-8-16-11-6-4-3-5-10(9)11/h3-6,8,12,16,23H,7H2,1-2H3,(H,17,20)(H,18,21)/t12-/m0/s1
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 1.50E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50112006
PNG
(CHEMBL367959 | N-Hydroxy-N'-[(S)-3-methyl-1-((S)-1...)
Show SMILES CC(C)C[C@H](NC(=O)C(=O)NO)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C16H23N3O4/c1-10(2)9-13(18-15(21)16(22)19-23)14(20)17-11(3)12-7-5-4-6-8-12/h4-8,10-11,13,23H,9H2,1-3H3,(H,17,20)(H,18,21)(H,19,22)/t11-,13-/m0/s1
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 2.00E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111998
PNG
(CHEMBL174993 | N-[(S)-1-Dimethylcarbamoyl-2-(4-phe...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccc(COc2ccccc2)cc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C20H23N3O5/c1-23(2)20(26)17(21-18(24)19(25)22-27)12-14-8-10-15(11-9-14)13-28-16-6-4-3-5-7-16/h3-11,17,27H,12-13H2,1-2H3,(H,21,24)(H,22,25)/t17-/m0/s1
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 2.20E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111993
PNG
(CHEMBL174373 | N-[(S)-1-Dimethylcarbamoyl-2-(1H-in...)
Show SMILES CN(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(=O)NO
Show InChI InChI=1S/C15H18N4O4/c1-19(2)15(22)12(17-13(20)14(21)18-23)7-9-8-16-11-6-4-3-5-10(9)11/h3-6,8,12,16,23H,7H2,1-2H3,(H,17,20)(H,18,21)/t12-/m0/s1
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 2.80E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50112004
PNG
(CHEMBL171466 | N-Hydroxy-N'-[(S)-2-naphthalen-1-yl...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C23H23N3O4/c1-15(16-8-3-2-4-9-16)24-21(27)20(25-22(28)23(29)26-30)14-18-12-7-11-17-10-5-6-13-19(17)18/h2-13,15,20,30H,14H2,1H3,(H,24,27)(H,25,28)(H,26,29)/t15-,20-/m0/s1
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 2.90E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50111983
PNG
(CHEMBL367722 | N-{(S)-1-[(R)-2-(4-Benzyloxy-phenyl...)
Show SMILES CCCC[C@H](NC(=O)C(=O)NO)C(=O)N[C@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N(C)C
Show InChI InChI=1S/C26H34N4O6/c1-4-5-11-21(27-24(32)25(33)29-35)23(31)28-22(26(34)30(2)3)16-18-12-14-20(15-13-18)36-17-19-9-7-6-8-10-19/h6-10,12-15,21-22,35H,4-5,11,16-17H2,1-3H3,(H,27,32)(H,28,31)(H,29,33)/t21-,22+/m0/s1
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 3.30E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50111996
PNG
(CHEMBL173382 | N-[2-(5-Chloro-1H-indol-3-yl)-ethyl...)
Show SMILES ONC(=O)C(=O)NCCc1c[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C12H12ClN3O3/c13-8-1-2-10-9(5-8)7(6-15-10)3-4-14-11(17)12(18)16-19/h1-2,5-6,15,19H,3-4H2,(H,14,17)(H,16,18)
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 3.50E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50112005
PNG
(CHEMBL355756 | N-((S)-1-Dimethylcarbamoyl-2-phenyl...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)C(=O)NO
Show InChI InChI=1S/C13H17N3O4/c1-16(2)13(19)10(14-11(17)12(18)15-20)8-9-6-4-3-5-7-9/h3-7,10,20H,8H2,1-2H3,(H,14,17)(H,15,18)/t10-/m0/s1
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 3.80E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50111987
PNG
(CHEMBL177048 | N-((S)-1-Dimethylcarbamoyl-2-naphth...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C(=O)NO
Show InChI InChI=1S/C17H19N3O4/c1-20(2)17(23)14(18-15(21)16(22)19-24)10-11-7-8-12-5-3-4-6-13(12)9-11/h3-9,14,24H,10H2,1-2H3,(H,18,21)(H,19,22)/t14-/m0/s1
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 4.40E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (matrix metalloproteinase-9)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50111985
PNG
(CHEMBL367331 | N-((S)-2-Benzyloxy-1-dimethylcarbam...)
Show SMILES CC(OCc1ccccc1)[C@H](NC(=O)C(=O)NO)C(=O)N(C)C
Show InChI InChI=1S/C15H21N3O5/c1-10(23-9-11-7-5-4-6-8-11)12(15(21)18(2)3)16-13(19)14(20)17-22/h4-8,10,12,22H,9H2,1-3H3,(H,16,19)(H,17,20)/t10?,12-/m0/s1
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 7.50E+4n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against neutrophil collagenase (Matrix metalloproteinase-8)

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50112001
PNG
(CHEMBL355727 | N-Hydroxy-N'-[(S)-1-((S)-1-phenyl-e...)
Show SMILES C[C@H](NC(=O)C(=O)NO)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C13H17N3O4/c1-8(10-6-4-3-5-7-10)14-11(17)9(2)15-12(18)13(19)16-20/h3-9,20H,1-2H3,(H,14,17)(H,15,18)(H,16,19)/t8-,9-/m0/s1
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 1.80E+5n/an/an/an/an/an/an/an/a



University of Bielefeld

Curated by ChEMBL


Assay Description
Inhibition of membrane type MT1-MMP (Matrix metalloproteinase-14)catalytic domain

Bioorg Med Chem Lett 12: 933-6 (2002)


BindingDB Entry DOI: 10.7270/Q20V8C35
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%