Affinity Data by PubMed id=11960485

PubMed code 11960485

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7501 (4-{(Z)-[4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-3...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.2	30
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7501 (4-{(Z)-[4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7500 ((2Z)-4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-2-(4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	7.2	30
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM5655 (2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	7.2	30
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7498 ((2Z)-2-benzylidene-4,6-dihydroxy-7-(1-methylpiperi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	7.2	30
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM5655 (2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7500 ((2Z)-4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-2-(4...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM5655 (2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7499 ((2Z)-2-(2-chlorobenzylidene)-4,6-dihydroxy-7-(1-me...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	7.2	30
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7502 ((2Z)-4,6-dihydroxy-2-[4-(4-methylpiperazin-1-yl)be...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	7.2	30
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7498 ((2Z)-2-benzylidene-4,6-dihydroxy-7-(1-methylpiperi...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM7501 (4-{(Z)-[4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM7502 ((2Z)-4,6-dihydroxy-2-[4-(4-methylpiperazin-1-yl)be...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.92E+3	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM7500 ((2Z)-4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-2-(4...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7502 ((2Z)-4,6-dihydroxy-2-[4-(4-methylpiperazin-1-yl)be...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.98E+3	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7499 ((2Z)-2-(2-chlorobenzylidene)-4,6-dihydroxy-7-(1-me...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.97E+3	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM7498 ((2Z)-2-benzylidene-4,6-dihydroxy-7-(1-methylpiperi...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.41E+3	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM7499 ((2Z)-2-(2-chlorobenzylidene)-4,6-dihydroxy-7-(1-me...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.53E+4	n/a	n/a	n/a	n/a	7.2	37
Novartis Pharmaceuticals					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...				J Med Chem 45: 1741-7 (2002) Article DOI: 10.1021/jm0108348 BindingDB Entry DOI: 10.7270/Q2707ZNJ
Novartis Pharmaceuticals					More data for this Ligand-Target Pair

* indicates data uncertainty>20%