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PubMed code 12109911

Compile data set for download or QSAR
Found 47 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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 0.160n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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 0.210n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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 0.390n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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 0.550n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2A receptor was determined using [3H]-ketanserin

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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 0.700n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2A receptor was determined using [3H]-ketanserin

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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 0.75n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2A receptor was determined using [3H]-ketanserin

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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 1.40n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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 1.5n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2A receptor was determined using [3H]-ketanserin

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50115641
PNG
((+/-)-7-2-Methyl-1,2,3,4,9,13b-hexahydro-2,4a-diaz...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccc(O)c21
Show InChI InChI=1S/C18H20N2O/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-17(21)18(14)20/h2-8,16,21H,9-12H2,1H3
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 2n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50115644
PNG
((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21
Show InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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 2n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2A receptor was determined using [3H]-ketanserin

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50115644
PNG
((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21
Show InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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 5.5n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50115641
PNG
((+/-)-7-2-Methyl-1,2,3,4,9,13b-hexahydro-2,4a-diaz...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccc(O)c21
Show InChI InChI=1S/C18H20N2O/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-17(21)18(14)20/h2-8,16,21H,9-12H2,1H3
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 12n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2A receptor was determined using [3H]-ketanserin

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50115644
PNG
((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21
Show InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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>18n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-hydroxytryptamine 1A receptor determined using [3H]-5-CT

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50115644
PNG
((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21
Show InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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>20n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D3 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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 20n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D2 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50115644
PNG
((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21
Show InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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>25n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D4 determined using [3H]-YM-09151-2

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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 28n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D2 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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 47n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D4 determined using [3H]-YM-09151-2

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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 70n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 3 receptor was determined using [3H]-LY-278,584

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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 80n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 1D receptor was determined using [3H]-5-CT

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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 92n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D4 determined using [3H]-YM-09151-2

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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 100n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D3 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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 160n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D4 determined using [3H]-YM-09151-2

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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 255n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-hydroxytryptamine 1A receptor determined using [3H]-5-CT

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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 260n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D3 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50115645
PNG
((+/-)-8Trifluoro-methanesulfonic acid 2-methyl-1,2...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccc(OS(=O)(=O)C(F)(F)F)c21
Show InChI InChI=1S/C19H19F3N2O3S/c1-23-9-10-24-16(12-23)15-7-3-2-5-13(15)11-14-6-4-8-17(18(14)24)27-28(25,26)19(20,21)22/h2-8,16H,9-12H2,1H3
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 277n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 2A receptor was determined using [3H]-ketanserin

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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 345n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-hydroxytryptamine 1A receptor determined using [3H]-5-CT

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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 460n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D2 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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>500n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-hydroxytryptamine 1A receptor determined using [3H]-5-CT

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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 800n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-hydroxytryptamine 1A receptor determined using [3H]-5-CT

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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 1.00E+3n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D2 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50115644
PNG
((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21
Show InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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 1.46E+3n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D2 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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 1.47E+3n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 1D receptor was determined using [3H]-5-CT

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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 1.65E+3n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 3 receptor was determined using [3H]-LY-278,584

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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 2.90E+3n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 3 receptor was determined using [3H]-LY-278,584

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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 3.57E+3n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Dopamine receptor D3 determined using [3H]-spiperone

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at 5-hydroxytryptamine 3 receptor was determined using [3H]-LY-278,584

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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n/an/a 22n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Norepinephrin transpoter reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50115644
PNG
((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21
Show InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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n/an/a>100n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-HT reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50115644
PNG
((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21
Show InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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n/an/a 260n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Norepinephrin transpoter reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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n/an/a 1.24E+3n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Norepinephrin transpoter reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50115642
PNG
((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...)
Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m1/s1
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n/an/a 1.65E+3n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-HT reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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n/an/a 1.78E+3n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Norepinephrin transpoter reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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UniProtKB/TrEMBL

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UniChem

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n/an/a 2.86E+3n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the Norepinephrin transpoter reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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n/an/a 2.90E+3n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-HT reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50115643
PNG
((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...)
Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-HT reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50115640
PNG
((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...)
Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-17(13-20)16-8-4-3-6-14(16)12-15-7-5-9-18(22-2)19(15)21/h3-9,17H,10-13H2,1-2H3/t17-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



University Center for Pharmacy

Curated by ChEMBL


Assay Description
The binding affinity of the compound at the 5-HT reputake sites determined using competition binding assay

J Med Chem 45: 3280-5 (2002)


BindingDB Entry DOI: 10.7270/Q28051ZZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%