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PubMed code 12113820

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50115794
PNG
(4-Methyl-7-oxo-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4...)
Show SMILES Cc1nc(nc2N(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)C(=O)CCc12)C(O)=O
Show InChI InChI=1S/C23H19N7O3/c1-13-16-10-11-19(31)30(22(16)25-21(24-13)23(32)33)12-14-6-8-15(9-7-14)17-4-2-3-5-18(17)20-26-28-29-27-20/h2-9H,10-12H2,1H3,(H,32,33)(H,26,27,28,29)
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n/an/a 23n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes

Bioorg Med Chem Lett 12: 1967-71 (2002)


BindingDB Entry DOI: 10.7270/Q2GF0SV5
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50040439
PNG
(2,4-Dimethyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-y...)
Show SMILES Cc1nc(C)c2CCC(=O)N(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2n1
Show InChI InChI=1S/C23H21N7O/c1-14-18-11-12-21(31)30(23(18)25-15(2)24-14)13-16-7-9-17(10-8-16)19-5-3-4-6-20(19)22-26-28-29-27-22/h3-10H,11-13H2,1-2H3,(H,26,27,28,29)
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n/an/a 38n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes

Bioorg Med Chem Lett 12: 1967-71 (2002)


BindingDB Entry DOI: 10.7270/Q2GF0SV5
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50115796
PNG
(2-Methyl-7-oxo-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4...)
Show SMILES Cc1nc2N(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)C(=O)CCc2c(n1)C(O)=O
Show InChI InChI=1S/C23H19N7O3/c1-13-24-20(23(32)33)18-10-11-19(31)30(22(18)25-13)12-14-6-8-15(9-7-14)16-4-2-3-5-17(16)21-26-28-29-27-21/h2-9H,10-12H2,1H3,(H,32,33)(H,26,27,28,29)
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n/an/a 44n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes

Bioorg Med Chem Lett 12: 1967-71 (2002)


BindingDB Entry DOI: 10.7270/Q2GF0SV5
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50115795
PNG
(2,4-Bis-hydroxymethyl-8-[2'-(2H-tetrazol-5-yl)-bip...)
Show SMILES OCc1nc(CO)c2ccc(=O)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2n1
Show InChI InChI=1S/C23H19N7O3/c31-12-19-18-9-10-21(33)30(23(18)25-20(13-32)24-19)11-14-5-7-15(8-6-14)16-3-1-2-4-17(16)22-26-28-29-27-22/h1-10,31-32H,11-13H2,(H,26,27,28,29)
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n/an/a 44n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes

Bioorg Med Chem Lett 12: 1967-71 (2002)


BindingDB Entry DOI: 10.7270/Q2GF0SV5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%