Affinity Data by PubMed id=12419386

PubMed code 12419386

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50121107 (CHEMBL324473 \| {3-[(1Z)-3-(allyloxy)-3-oxoprop-1-e...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	8.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Binding affinity towards protein-tyrosine phosphatase 1B (PTP1B)				Bioorg Med Chem Lett 12: 3471-4 (2002) BindingDB Entry DOI: 10.7270/Q2B27VVM
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50121106 (1,1'-biphenyl-3-yl(difluoro)methylphosphonate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibitory concentration against protein-tyrosine phosphatase 1B (PTB 1B)				Bioorg Med Chem Lett 12: 3471-4 (2002) BindingDB Entry DOI: 10.7270/Q2B27VVM
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50075302 ((3-ethynylphenyl)(difluoro)methylphosphonate \| CHE...) Show SMILES OP(O)(=O)C(F)(F)c1cccc(c1)C#C Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibitory concentration against protein-tyrosine phosphatase 1B (PTB 1B)				Bioorg Med Chem Lett 12: 3471-4 (2002) BindingDB Entry DOI: 10.7270/Q2B27VVM
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50075314 (CHEMBL151300 \| difluoro{3-[(E)-2-phenylvinyl]pheny...) Show SMILES OP(O)(=O)C(F)(F)c1cccc(\C=C\c2ccccc2)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.86E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Concentration at which it inhibits protein-tyrosine phosphatase 1B (PTB 1B) was determined; Weak inhibition				Bioorg Med Chem Lett 12: 3471-4 (2002) BindingDB Entry DOI: 10.7270/Q2B27VVM
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50121107 (CHEMBL324473 \| {3-[(1Z)-3-(allyloxy)-3-oxoprop-1-e...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.22E+7	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibitory concentration against Protein-tyrosine phosphatase 1B (PTP1B)				Bioorg Med Chem Lett 12: 3471-4 (2002) BindingDB Entry DOI: 10.7270/Q2B27VVM
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%