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PubMed code 12672245

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50366775
PNG
(BENZTROPINE | Benzatropine)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20+
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 118n/an/an/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50366564
PNG
(CHEMBL1790051 | CHEMBL83729 | WIN-35065-2)
Show SMILES COC(=O)[C@@H]1C2CC[C@H](C[C@@H]1c1ccccc1)N2C |r,TLB:11:10:17:6.7,THB:2:4:17:6.7|
Show InChI InChI=1S/C16H21NO2/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13-,14?,15+/m1/s1
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n/an/a 23n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50366564
PNG
(CHEMBL1790051 | CHEMBL83729 | WIN-35065-2)
Show SMILES COC(=O)[C@@H]1C2CC[C@H](C[C@@H]1c1ccccc1)N2C |r,TLB:11:10:17:6.7,THB:2:4:17:6.7|
Show InChI InChI=1S/C16H21NO2/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13-,14?,15+/m1/s1
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n/an/a 23n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126803
PNG
(8-(4-Chloro-phenyl)-3-aza-bicyclo[3.2.1]octane | C...)
Show SMILES Clc1ccc(cc1)C1C2CCC1CNC2 |THB:4:7:9.10:13.12.14|
Show InChI InChI=1S/C13H16ClN/c14-12-5-3-9(4-6-12)13-10-1-2-11(13)8-15-7-10/h3-6,10-11,13,15H,1-2,7-8H2
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n/an/a 81.5n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126808
PNG
(3-Benzyl-8-(4-chloro-phenyl)-3-aza-bicyclo[3.2.1]o...)
Show SMILES Clc1ccc(cc1)C1C2CCC1CN(Cc1ccccc1)C2 |THB:4:7:13.21.12:9.10,14:13:7:9.10|
Show InChI InChI=1S/C20H22ClN/c21-19-10-8-16(9-11-19)20-17-6-7-18(20)14-22(13-17)12-15-4-2-1-3-5-15/h1-5,8-11,17-18,20H,6-7,12-14H2
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n/an/a 95.5n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50084717
PNG
((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1C(=O)Oc1ccccc1)N2C |THB:2:4:20:6.7|
Show InChI InChI=1S/C17H21NO4/c1-18-11-8-9-14(18)15(17(20)21-2)13(10-11)16(19)22-12-6-4-3-5-7-12/h3-7,11,13-15H,8-10H2,1-2H3/t11?,13-,14?,15-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126807
PNG
(8-(4-Chloro-phenyl)-3-methyl-3-aza-bicyclo[3.2.1]o...)
Show SMILES CN1CC2CCC(C1)C2c1ccc(Cl)cc1 |TLB:0:1:8:4.5,THB:9:8:1.2.7:4.5|
Show InChI InChI=1S/C14H18ClN/c1-16-8-11-2-3-12(9-16)14(11)10-4-6-13(15)7-5-10/h4-7,11-12,14H,2-3,8-9H2,1H3
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n/an/a 220n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126801
PNG
(3-BENZYL-8-PHENYL-3-AZA-BICYCLO[3.2.1]OCTANE (STER...)
Show SMILES C(N1CC2CCC(C1)C2c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C20H23N/c1-3-7-16(8-4-1)13-21-14-18-11-12-19(15-21)20(18)17-9-5-2-6-10-17/h1-10,18-20H,11-15H2
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n/an/a 234n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126801
PNG
(3-BENZYL-8-PHENYL-3-AZA-BICYCLO[3.2.1]OCTANE (STER...)
Show SMILES C(N1CC2CCC(C1)C2c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C20H23N/c1-3-7-16(8-4-1)13-21-14-18-11-12-19(15-21)20(18)17-9-5-2-6-10-17/h1-10,18-20H,11-15H2
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n/an/a 234n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126799
PNG
(8-Phenyl-3-aza-bicyclo[3.2.1]octane | CHEMBL36059)
Show SMILES C1CC2CNCC1C2c1ccccc1 |THB:8:7:0.1:4.3.5|
Show InChI InChI=1S/C13H17N/c1-2-4-10(5-3-1)13-11-6-7-12(13)9-14-8-11/h1-5,11-14H,6-9H2
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n/an/a 258n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126807
PNG
(8-(4-Chloro-phenyl)-3-methyl-3-aza-bicyclo[3.2.1]o...)
Show SMILES CN1CC2CCC(C1)C2c1ccc(Cl)cc1 |TLB:0:1:8:4.5,THB:9:8:1.2.7:4.5|
Show InChI InChI=1S/C14H18ClN/c1-16-8-11-2-3-12(9-16)14(11)10-4-6-13(15)7-5-10/h4-7,11-12,14H,2-3,8-9H2,1H3
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n/an/a 273n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126801
PNG
(3-BENZYL-8-PHENYL-3-AZA-BICYCLO[3.2.1]OCTANE (STER...)
Show SMILES C(N1CC2CCC(C1)C2c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C20H23N/c1-3-7-16(8-4-1)13-21-14-18-11-12-19(15-21)20(18)17-9-5-2-6-10-17/h1-10,18-20H,11-15H2
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n/an/a 309n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126801
PNG
(3-BENZYL-8-PHENYL-3-AZA-BICYCLO[3.2.1]OCTANE (STER...)
Show SMILES C(N1CC2CCC(C1)C2c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C20H23N/c1-3-7-16(8-4-1)13-21-14-18-11-12-19(15-21)20(18)17-9-5-2-6-10-17/h1-10,18-20H,11-15H2
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n/an/a 309n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126802
PNG
(3-Methyl-8-phenyl-3-aza-bicyclo[3.2.1]octane | CHE...)
Show SMILES CN1CC2CCC(C1)C2c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C14H19N/c1-15-9-12-7-8-13(10-15)14(12)11-5-3-2-4-6-11/h2-6,12-14H,7-10H2,1H3
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n/an/a 360n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126803
PNG
(8-(4-Chloro-phenyl)-3-aza-bicyclo[3.2.1]octane | C...)
Show SMILES Clc1ccc(cc1)C1C2CCC1CNC2 |THB:4:7:9.10:13.12.14|
Show InChI InChI=1S/C13H16ClN/c14-12-5-3-9(4-6-12)13-10-1-2-11(13)8-15-7-10/h3-6,10-11,13,15H,1-2,7-8H2
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n/an/a 363n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50084717
PNG
((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1C(=O)Oc1ccccc1)N2C |THB:2:4:20:6.7|
Show InChI InChI=1S/C17H21NO4/c1-18-11-8-9-14(18)15(17(20)21-2)13(10-11)16(19)22-12-6-4-3-5-7-12/h3-7,11,13-15H,8-10H2,1-2H3/t11?,13-,14?,15-/m0/s1
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n/an/a 389n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126808
PNG
(3-Benzyl-8-(4-chloro-phenyl)-3-aza-bicyclo[3.2.1]o...)
Show SMILES Clc1ccc(cc1)C1C2CCC1CN(Cc1ccccc1)C2 |THB:4:7:13.21.12:9.10,14:13:7:9.10|
Show InChI InChI=1S/C20H22ClN/c21-19-10-8-16(9-11-19)20-17-6-7-18(20)14-22(13-17)12-15-4-2-1-3-5-15/h1-5,8-11,17-18,20H,6-7,12-14H2
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n/an/a 402n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50084717
PNG
((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1C(=O)Oc1ccccc1)N2C |THB:2:4:20:6.7|
Show InChI InChI=1S/C17H21NO4/c1-18-11-8-9-14(18)15(17(20)21-2)13(10-11)16(19)22-12-6-4-3-5-7-12/h3-7,11,13-15H,8-10H2,1-2H3/t11?,13-,14?,15-/m0/s1
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n/an/a 404n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126803
PNG
(8-(4-Chloro-phenyl)-3-aza-bicyclo[3.2.1]octane | C...)
Show SMILES Clc1ccc(cc1)C1C2CCC1CNC2 |THB:4:7:9.10:13.12.14|
Show InChI InChI=1S/C13H16ClN/c14-12-5-3-9(4-6-12)13-10-1-2-11(13)8-15-7-10/h3-6,10-11,13,15H,1-2,7-8H2
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n/an/a 478n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126812
PNG
(8-Benzhydryloxy-3-benzyl-3-aza-bicyclo[3.2.1]octan...)
Show SMILES C(N1CC2CCC(C1)C2OC(c1ccccc1)c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C27H29NO/c1-4-10-21(11-5-1)18-28-19-24-16-17-25(20-28)27(24)29-26(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,24-27H,16-20H2
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n/an/a 536n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126812
PNG
(8-Benzhydryloxy-3-benzyl-3-aza-bicyclo[3.2.1]octan...)
Show SMILES C(N1CC2CCC(C1)C2OC(c1ccccc1)c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C27H29NO/c1-4-10-21(11-5-1)18-28-19-24-16-17-25(20-28)27(24)29-26(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,24-27H,16-20H2
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n/an/a 536n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126808
PNG
(3-Benzyl-8-(4-chloro-phenyl)-3-aza-bicyclo[3.2.1]o...)
Show SMILES Clc1ccc(cc1)C1C2CCC1CN(Cc1ccccc1)C2 |THB:4:7:13.21.12:9.10,14:13:7:9.10|
Show InChI InChI=1S/C20H22ClN/c21-19-10-8-16(9-11-19)20-17-6-7-18(20)14-22(13-17)12-15-4-2-1-3-5-15/h1-5,8-11,17-18,20H,6-7,12-14H2
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n/an/a 601n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126799
PNG
(8-Phenyl-3-aza-bicyclo[3.2.1]octane | CHEMBL36059)
Show SMILES C1CC2CNCC1C2c1ccccc1 |THB:8:7:0.1:4.3.5|
Show InChI InChI=1S/C13H17N/c1-2-4-10(5-3-1)13-11-6-7-12(13)9-14-8-11/h1-5,11-14H,6-9H2
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n/an/a 893n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126807
PNG
(8-(4-Chloro-phenyl)-3-methyl-3-aza-bicyclo[3.2.1]o...)
Show SMILES CN1CC2CCC(C1)C2c1ccc(Cl)cc1 |TLB:0:1:8:4.5,THB:9:8:1.2.7:4.5|
Show InChI InChI=1S/C14H18ClN/c1-16-8-11-2-3-12(9-16)14(11)10-4-6-13(15)7-5-10/h4-7,11-12,14H,2-3,8-9H2,1H3
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n/an/a 926n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126804
PNG
(3-Benzyl-8-(4-chloro-phenyl)-3-aza-bicyclo[3.2.1]o...)
Show SMILES OC1(C2CCC1CN(Cc1ccccc1)C2)c1ccc(Cl)cc1 |TLB:16:1:7.15.6:3.4,THB:8:7:1:3.4,0:1:7.15.6:3.4|
Show InChI InChI=1S/C20H22ClNO/c21-19-10-8-16(9-11-19)20(23)17-6-7-18(20)14-22(13-17)12-15-4-2-1-3-5-15/h1-5,8-11,17-18,23H,6-7,12-14H2
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n/an/a 997n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126802
PNG
(3-Methyl-8-phenyl-3-aza-bicyclo[3.2.1]octane | CHE...)
Show SMILES CN1CC2CCC(C1)C2c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C14H19N/c1-15-9-12-7-8-13(10-15)14(12)11-5-3-2-4-6-11/h2-6,12-14H,7-10H2,1H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126804
PNG
(3-Benzyl-8-(4-chloro-phenyl)-3-aza-bicyclo[3.2.1]o...)
Show SMILES OC1(C2CCC1CN(Cc1ccccc1)C2)c1ccc(Cl)cc1 |TLB:16:1:7.15.6:3.4,THB:8:7:1:3.4,0:1:7.15.6:3.4|
Show InChI InChI=1S/C20H22ClNO/c21-19-10-8-16(9-11-19)20(23)17-6-7-18(20)14-22(13-17)12-15-4-2-1-3-5-15/h1-5,8-11,17-18,23H,6-7,12-14H2
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n/an/a 1.51E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126802
PNG
(3-Methyl-8-phenyl-3-aza-bicyclo[3.2.1]octane | CHE...)
Show SMILES CN1CC2CCC(C1)C2c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C14H19N/c1-15-9-12-7-8-13(10-15)14(12)11-5-3-2-4-6-11/h2-6,12-14H,7-10H2,1H3
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n/an/a 1.85E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126812
PNG
(8-Benzhydryloxy-3-benzyl-3-aza-bicyclo[3.2.1]octan...)
Show SMILES C(N1CC2CCC(C1)C2OC(c1ccccc1)c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C27H29NO/c1-4-10-21(11-5-1)18-28-19-24-16-17-25(20-28)27(24)29-26(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,24-27H,16-20H2
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n/an/a 1.98E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126812
PNG
(8-Benzhydryloxy-3-benzyl-3-aza-bicyclo[3.2.1]octan...)
Show SMILES C(N1CC2CCC(C1)C2OC(c1ccccc1)c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C27H29NO/c1-4-10-21(11-5-1)18-28-19-24-16-17-25(20-28)27(24)29-26(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,24-27H,16-20H2
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n/an/a 1.98E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126804
PNG
(3-Benzyl-8-(4-chloro-phenyl)-3-aza-bicyclo[3.2.1]o...)
Show SMILES OC1(C2CCC1CN(Cc1ccccc1)C2)c1ccc(Cl)cc1 |TLB:16:1:7.15.6:3.4,THB:8:7:1:3.4,0:1:7.15.6:3.4|
Show InChI InChI=1S/C20H22ClNO/c21-19-10-8-16(9-11-19)20(23)17-6-7-18(20)14-22(13-17)12-15-4-2-1-3-5-15/h1-5,8-11,17-18,23H,6-7,12-14H2
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n/an/a 2.63E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126798
PNG
(3-Benzyl-8-phenyl-3-aza-bicyclo[3.2.1]octan-8-ol |...)
Show SMILES OC1(C2CCC1CN(Cc1ccccc1)C2)c1ccccc1 |TLB:16:1:7.6.15:3.4,THB:8:7:1:3.4,0:1:7.6.15:3.4|
Show InChI InChI=1S/C20H23NO/c22-20(17-9-5-2-6-10-17)18-11-12-19(20)15-21(14-18)13-16-7-3-1-4-8-16/h1-10,18-19,22H,11-15H2
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n/an/a 3.06E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126801
PNG
(3-BENZYL-8-PHENYL-3-AZA-BICYCLO[3.2.1]OCTANE (STER...)
Show SMILES C(N1CC2CCC(C1)C2c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C20H23N/c1-3-7-16(8-4-1)13-21-14-18-11-12-19(15-21)20(18)17-9-5-2-6-10-17/h1-10,18-20H,11-15H2
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n/an/a 3.46E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126801
PNG
(3-BENZYL-8-PHENYL-3-AZA-BICYCLO[3.2.1]OCTANE (STER...)
Show SMILES C(N1CC2CCC(C1)C2c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C20H23N/c1-3-7-16(8-4-1)13-21-14-18-11-12-19(15-21)20(18)17-9-5-2-6-10-17/h1-10,18-20H,11-15H2
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n/an/a 3.46E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126799
PNG
(8-Phenyl-3-aza-bicyclo[3.2.1]octane | CHEMBL36059)
Show SMILES C1CC2CNCC1C2c1ccccc1 |THB:8:7:0.1:4.3.5|
Show InChI InChI=1S/C13H17N/c1-2-4-10(5-3-1)13-11-6-7-12(13)9-14-8-11/h1-5,11-14H,6-9H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126811
PNG
(3-Benzyl-8-bromo-3-aza-bicyclo[3.2.1]octane | CHEM...)
Show SMILES BrC1C2CCC1CN(Cc1ccccc1)C2 |TLB:0:1:7.6.15:3.4,THB:8:7:1:3.4|
Show InChI InChI=1S/C14H18BrN/c15-14-12-6-7-13(14)10-16(9-12)8-11-4-2-1-3-5-11/h1-5,12-14H,6-10H2
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n/an/a 4.63E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126810
PNG
(8-Phenyl-3-aza-bicyclo[3.2.1]octan-8-ol | CHEMBL32...)
Show SMILES OC1(C2CCC1CNC2)c1ccccc1 |TLB:9:1:3.4:7.8.6,THB:0:1:3.4:7.8.6|
Show InChI InChI=1S/C13H17NO/c15-13(10-4-2-1-3-5-10)11-6-7-12(13)9-14-8-11/h1-5,11-12,14-15H,6-9H2
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n/an/a 8.48E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126811
PNG
(3-Benzyl-8-bromo-3-aza-bicyclo[3.2.1]octane | CHEM...)
Show SMILES BrC1C2CCC1CN(Cc1ccccc1)C2 |TLB:0:1:7.6.15:3.4,THB:8:7:1:3.4|
Show InChI InChI=1S/C14H18BrN/c15-14-12-6-7-13(14)10-16(9-12)8-11-4-2-1-3-5-11/h1-5,12-14H,6-10H2
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n/an/a 8.64E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126809
PNG
(3-Methyl-8-phenyl-3-aza-bicyclo[3.2.1]octan-8-ol |...)
Show SMILES CN1CC2CCC(C1)C2(O)c1ccccc1 |TLB:10:8:1.7.2:4.5,0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C14H19NO/c1-15-9-12-7-8-13(10-15)14(12,16)11-5-3-2-4-6-11/h2-6,12-13,16H,7-10H2,1H3
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n/an/a 9.77E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126810
PNG
(8-Phenyl-3-aza-bicyclo[3.2.1]octan-8-ol | CHEMBL32...)
Show SMILES OC1(C2CCC1CNC2)c1ccccc1 |TLB:9:1:3.4:7.8.6,THB:0:1:3.4:7.8.6|
Show InChI InChI=1S/C13H17NO/c15-13(10-4-2-1-3-5-10)11-6-7-12(13)9-14-8-11/h1-5,11-12,14-15H,6-9H2
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n/an/a 9.83E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126811
PNG
(3-Benzyl-8-bromo-3-aza-bicyclo[3.2.1]octane | CHEM...)
Show SMILES BrC1C2CCC1CN(Cc1ccccc1)C2 |TLB:0:1:7.6.15:3.4,THB:8:7:1:3.4|
Show InChI InChI=1S/C14H18BrN/c15-14-12-6-7-13(14)10-16(9-12)8-11-4-2-1-3-5-11/h1-5,12-14H,6-10H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126806
PNG
(3-Benzyl-3-aza-bicyclo[3.2.1]octane | CHEMBL35558)
Show SMILES C(N1CC2CCC(C2)C1)c1ccccc1 |TLB:0:1:7:4.5|
Show InChI InChI=1S/C14H19N/c1-2-4-12(5-3-1)9-15-10-13-6-7-14(8-13)11-15/h1-5,13-14H,6-11H2
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School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126809
PNG
(3-Methyl-8-phenyl-3-aza-bicyclo[3.2.1]octan-8-ol |...)
Show SMILES CN1CC2CCC(C1)C2(O)c1ccccc1 |TLB:10:8:1.7.2:4.5,0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C14H19NO/c1-15-9-12-7-8-13(10-15)14(12,16)11-5-3-2-4-6-11/h2-6,12-13,16H,7-10H2,1H3
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School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126812
PNG
(8-Benzhydryloxy-3-benzyl-3-aza-bicyclo[3.2.1]octan...)
Show SMILES C(N1CC2CCC(C1)C2OC(c1ccccc1)c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C27H29NO/c1-4-10-21(11-5-1)18-28-19-24-16-17-25(20-28)27(24)29-26(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,24-27H,16-20H2
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School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126805
PNG
(3-Benzyl-3-aza-bicyclo[3.2.1]octan-8-ol | CHEMBL32...)
Show SMILES OC1C2CCC1CN(Cc1ccccc1)C2 |THB:8:7:1:3.4,0:1:7.6.15:3.4|
Show InChI InChI=1S/C14H19NO/c16-14-12-6-7-13(14)10-15(9-12)8-11-4-2-1-3-5-11/h1-5,12-14,16H,6-10H2
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School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126810
PNG
(8-Phenyl-3-aza-bicyclo[3.2.1]octan-8-ol | CHEMBL32...)
Show SMILES OC1(C2CCC1CNC2)c1ccccc1 |TLB:9:1:3.4:7.8.6,THB:0:1:3.4:7.8.6|
Show InChI InChI=1S/C13H17NO/c15-13(10-4-2-1-3-5-10)11-6-7-12(13)9-14-8-11/h1-5,11-12,14-15H,6-9H2
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School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50126812
PNG
(8-Benzhydryloxy-3-benzyl-3-aza-bicyclo[3.2.1]octan...)
Show SMILES C(N1CC2CCC(C1)C2OC(c1ccccc1)c1ccccc1)c1ccccc1 |TLB:0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C27H29NO/c1-4-10-21(11-5-1)18-28-19-24-16-17-25(20-28)27(24)29-26(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,24-27H,16-20H2
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School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]citalopram binding to Serotonin transporter (5-HTT) in rat cortical tissue.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126809
PNG
(3-Methyl-8-phenyl-3-aza-bicyclo[3.2.1]octan-8-ol |...)
Show SMILES CN1CC2CCC(C1)C2(O)c1ccccc1 |TLB:10:8:1.7.2:4.5,0:1:8:4.5,THB:9:8:1.7.2:4.5|
Show InChI InChI=1S/C14H19NO/c1-15-9-12-7-8-13(10-15)14(12,16)11-5-3-2-4-6-11/h2-6,12-13,16H,7-10H2,1H3
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n/an/a 1.01E+4n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126798
PNG
(3-Benzyl-8-phenyl-3-aza-bicyclo[3.2.1]octan-8-ol |...)
Show SMILES OC1(C2CCC1CN(Cc1ccccc1)C2)c1ccccc1 |TLB:16:1:7.6.15:3.4,THB:8:7:1:3.4,0:1:7.6.15:3.4|
Show InChI InChI=1S/C20H23NO/c22-20(17-9-5-2-6-10-17)18-11-12-19(20)15-21(14-18)13-16-7-3-1-4-8-16/h1-10,18-19,22H,11-15H2
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n/an/a 1.75E+4n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126805
PNG
(3-Benzyl-3-aza-bicyclo[3.2.1]octan-8-ol | CHEMBL32...)
Show SMILES OC1C2CCC1CN(Cc1ccccc1)C2 |THB:8:7:1:3.4,0:1:7.6.15:3.4|
Show InChI InChI=1S/C14H19NO/c16-14-12-6-7-13(14)10-15(9-12)8-11-4-2-1-3-5-11/h1-5,12-14,16H,6-10H2
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n/an/a 2.21E+4n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126806
PNG
(3-Benzyl-3-aza-bicyclo[3.2.1]octane | CHEMBL35558)
Show SMILES C(N1CC2CCC(C2)C1)c1ccccc1 |TLB:0:1:7:4.5|
Show InChI InChI=1S/C14H19N/c1-2-4-12(5-3-1)9-15-10-13-6-7-14(8-13)11-15/h1-5,13-14H,6-11H2
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n/an/a 2.43E+4n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126798
PNG
(3-Benzyl-8-phenyl-3-aza-bicyclo[3.2.1]octan-8-ol |...)
Show SMILES OC1(C2CCC1CN(Cc1ccccc1)C2)c1ccccc1 |TLB:16:1:7.6.15:3.4,THB:8:7:1:3.4,0:1:7.6.15:3.4|
Show InChI InChI=1S/C20H23NO/c22-20(17-9-5-2-6-10-17)18-11-12-19(20)15-21(14-18)13-16-7-3-1-4-8-16/h1-10,18-19,22H,11-15H2
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n/an/a 2.71E+4n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126806
PNG
(3-Benzyl-3-aza-bicyclo[3.2.1]octane | CHEMBL35558)
Show SMILES C(N1CC2CCC(C2)C1)c1ccccc1 |TLB:0:1:7:4.5|
Show InChI InChI=1S/C14H19N/c1-2-4-12(5-3-1)9-15-10-13-6-7-14(8-13)11-15/h1-5,13-14H,6-11H2
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n/an/a 3.57E+4n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50126805
PNG
(3-Benzyl-3-aza-bicyclo[3.2.1]octan-8-ol | CHEMBL32...)
Show SMILES OC1C2CCC1CN(Cc1ccccc1)C2 |THB:8:7:1:3.4,0:1:7.6.15:3.4|
Show InChI InChI=1S/C14H19NO/c16-14-12-6-7-13(14)10-15(9-12)8-11-4-2-1-3-5-11/h1-5,12-14,16H,6-10H2
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n/an/a 4.50E+4n/an/an/an/an/an/a



School of Chemistry and Biochemistry

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to DAT in rat striatal synaptosomes.

J Med Chem 46: 1456-64 (2003)


Article DOI: 10.1021/jm020410t
BindingDB Entry DOI: 10.7270/Q2W096PJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%