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PubMed code 14698163

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50223719
PNG
(CHEMBL3348530)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(O)=O |wU:22.22,58.61,36.38,4.3,wD:9.8,18.72,47.49,(-2.84,-13.67,;-1.44,-13.06,;-.19,-13.98,;1.22,-13.36,;2.45,-14.28,;2.29,-15.82,;3.87,-13.67,;5.11,-14.58,;4.05,-12.14,;5.46,-11.52,;6.26,-12.84,;7.39,-13.9,;6.5,-15.16,;8.75,-14.6,;10.25,-14.91,;11.79,-14.81,;13.26,-14.29,;14.51,-13.41,;15.48,-12.21,;16.1,-10.8,;16.3,-9.27,;17.84,-9.27,;16.1,-7.75,;17.58,-7.33,;18.66,-6.24,;18.4,-4.7,;19.77,-3.99,;20.87,-5.08,;22.4,-4.98,;23.27,-6.26,;22.57,-7.64,;21.03,-7.74,;20.17,-6.46,;15.48,-6.34,;14.51,-5.13,;15.56,-4.01,;13.26,-4.25,;13.95,-2.87,;15.49,-2.82,;16.21,-1.44,;17.75,-1.37,;18.45,-.01,;19.98,.06,;17.62,1.3,;11.79,-3.73,;10.25,-3.63,;10.16,-2.1,;8.75,-3.94,;8.23,-2.49,;9.23,-1.31,;10.76,-1.59,;11.76,-.43,;11.23,1.02,;9.72,1.3,;8.72,.13,;7.39,-4.66,;6.26,-5.7,;5.06,-4.73,;5.46,-7.02,;4.05,-6.4,;3.87,-4.87,;5.01,-3.84,;4.36,-2.43,;2.84,-2.61,;2.54,-4.11,;5.04,-8.51,;5.04,-10.04,;3.52,-10.25,;16.79,-13.01,;18.14,-12.28,;16.76,-14.55,)|
Show InChI InChI=1S/C48H66N14O9/c1-2-3-15-32(49)41(64)59-39-24-40(63)53-19-10-9-17-35(47(70)71)58-44(67)37(22-29-25-55-33-16-8-7-14-31(29)33)61-42(65)34(18-11-20-54-48(50)51)57-43(66)36(21-28-12-5-4-6-13-28)60-45(68)38(62-46(39)69)23-30-26-52-27-56-30/h4-8,12-14,16,25-27,32,34-39,55H,2-3,9-11,15,17-24,49H2,1H3,(H,52,56)(H,53,63)(H,57,66)(H,58,67)(H,59,64)(H,60,68)(H,61,65)(H,62,69)(H,70,71)(H4,50,51,54)/t32-,34-,35-,36+,37-,38-,39-/m0/s1
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n/an/a 0.0600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138293
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CC(C)(C)CC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C36H50ClN5O5S/c1-36(2,3)25-34(44)40-19-17-39(18-20-40)33(43)24-29(23-27-11-13-30(37)14-12-27)35(45)41-21-15-38(16-22-41)31-7-5-6-8-32(31)42(48(4,46)47)26-28-9-10-28/h5-8,11-14,28-29H,9-10,15-26H2,1-4H3/t29-/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50223719
PNG
(CHEMBL3348530)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(O)=O |wU:22.22,58.61,36.38,4.3,wD:9.8,18.72,47.49,(-2.84,-13.67,;-1.44,-13.06,;-.19,-13.98,;1.22,-13.36,;2.45,-14.28,;2.29,-15.82,;3.87,-13.67,;5.11,-14.58,;4.05,-12.14,;5.46,-11.52,;6.26,-12.84,;7.39,-13.9,;6.5,-15.16,;8.75,-14.6,;10.25,-14.91,;11.79,-14.81,;13.26,-14.29,;14.51,-13.41,;15.48,-12.21,;16.1,-10.8,;16.3,-9.27,;17.84,-9.27,;16.1,-7.75,;17.58,-7.33,;18.66,-6.24,;18.4,-4.7,;19.77,-3.99,;20.87,-5.08,;22.4,-4.98,;23.27,-6.26,;22.57,-7.64,;21.03,-7.74,;20.17,-6.46,;15.48,-6.34,;14.51,-5.13,;15.56,-4.01,;13.26,-4.25,;13.95,-2.87,;15.49,-2.82,;16.21,-1.44,;17.75,-1.37,;18.45,-.01,;19.98,.06,;17.62,1.3,;11.79,-3.73,;10.25,-3.63,;10.16,-2.1,;8.75,-3.94,;8.23,-2.49,;9.23,-1.31,;10.76,-1.59,;11.76,-.43,;11.23,1.02,;9.72,1.3,;8.72,.13,;7.39,-4.66,;6.26,-5.7,;5.06,-4.73,;5.46,-7.02,;4.05,-6.4,;3.87,-4.87,;5.01,-3.84,;4.36,-2.43,;2.84,-2.61,;2.54,-4.11,;5.04,-8.51,;5.04,-10.04,;3.52,-10.25,;16.79,-13.01,;18.14,-12.28,;16.76,-14.55,)|
Show InChI InChI=1S/C48H66N14O9/c1-2-3-15-32(49)41(64)59-39-24-40(63)53-19-10-9-17-35(47(70)71)58-44(67)37(22-29-25-55-33-16-8-7-14-31(29)33)61-42(65)34(18-11-20-54-48(50)51)57-43(66)36(21-28-12-5-4-6-13-28)60-45(68)38(62-46(39)69)23-30-26-52-27-56-30/h4-8,12-14,16,25-27,32,34-39,55H,2-3,9-11,15,17-24,49H2,1H3,(H,52,56)(H,53,63)(H,57,66)(H,58,67)(H,59,64)(H,60,68)(H,61,65)(H,62,69)(H,70,71)(H4,50,51,54)/t32-,34-,35-,36+,37-,38-,39-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138288
PNG
(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C33H44ClN5O6S/c1-3-45-33(42)38-20-16-36(17-21-38)31(40)23-27(22-25-10-12-28(34)13-11-25)32(41)37-18-14-35(15-19-37)29-6-4-5-7-30(29)39(46(2,43)44)24-26-8-9-26/h4-7,10-13,26-27H,3,8-9,14-24H2,1-2H3/t27-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138301
PNG
(4-[(S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phen...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCN(CC1)C(=O)OC(C)(C)C)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C36H50ClN5O5/c1-7-42(27(3)43)26(2)31-10-8-9-11-32(31)38-16-20-40(21-17-38)34(45)29(24-28-12-14-30(37)15-13-28)25-33(44)39-18-22-41(23-19-39)35(46)47-36(4,5)6/h8-15,26,29H,7,16-25H2,1-6H3/t26?,29-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138290
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCN(CC2CC2)CC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C34H46ClN5O4S/c1-45(43,44)40(25-28-8-9-28)32-5-3-2-4-31(32)37-18-20-39(21-19-37)34(42)29(22-26-10-12-30(35)13-11-26)23-33(41)38-16-14-36(15-17-38)24-27-6-7-27/h2-5,10-13,27-29H,6-9,14-25H2,1H3/t29-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138294
PNG
(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C35H48ClN5O6S/c1-35(2,3)47-34(44)40-21-17-38(18-22-40)32(42)24-28(23-26-11-13-29(36)14-12-26)33(43)39-19-15-37(16-20-39)30-7-5-6-8-31(30)41(48(4,45)46)25-27-9-10-27/h5-8,11-14,27-28H,9-10,15-25H2,1-4H3/t28-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138303
PNG
((S)-4-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-benzy...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCN(CC1)C(=O)c1ccccc1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C37H44ClN5O5S/c1-49(47,48)43(27-29-11-12-29)34-10-6-5-9-33(34)39-17-21-42(22-18-39)37(46)31(25-28-13-15-32(38)16-14-28)26-35(44)40-19-23-41(24-20-40)36(45)30-7-3-2-4-8-30/h2-10,13-16,29,31H,11-12,17-27H2,1H3/t31-/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138305
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CC(C)CCN1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C35H50ClN5O4S/c1-27(2)14-15-37-16-18-39(19-17-37)34(42)25-30(24-28-10-12-31(36)13-11-28)35(43)40-22-20-38(21-23-40)32-6-4-5-7-33(32)41(46(3,44)45)26-29-8-9-29/h4-7,10-13,27,29-30H,8-9,14-26H2,1-3H3/t30-/m0/s1
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n/an/a 4.80n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138296
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NC1CCC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C31H41ClN4O3/c1-4-36(23(3)37)22(2)28-10-5-6-11-29(28)34-16-18-35(19-17-34)31(39)25(20-24-12-14-26(32)15-13-24)21-30(38)33-27-8-7-9-27/h5-6,10-15,22,25,27H,4,7-9,16-21H2,1-3H3,(H,33,38)/t22?,25-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138292
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CCCN1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C33H46ClN5O4S/c1-3-14-35-15-17-37(18-16-35)32(40)24-28(23-26-10-12-29(34)13-11-26)33(41)38-21-19-36(20-22-38)30-6-4-5-7-31(30)39(44(2,42)43)25-27-8-9-27/h4-7,10-13,27-28H,3,8-9,14-25H2,1-2H3/t28-/m0/s1
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n/an/a 8.90n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138302
PNG
(CHEMBL125079 | N-[1-(2-{4-[(S)-2-(4-Chloro-benzyl)...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCSC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C30H39ClN4O3S/c1-4-35(23(3)36)22(2)27-7-5-6-8-28(27)32-13-15-33(16-14-32)30(38)25(19-24-9-11-26(31)12-10-24)20-29(37)34-17-18-39-21-34/h5-12,22,25H,4,13-21H2,1-3H3/t22?,25-/m0/s1
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n/an/a 9.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138291
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CCN1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C32H44ClN5O4S/c1-3-34-14-16-36(17-15-34)31(39)23-27(22-25-10-12-28(33)13-11-25)32(40)37-20-18-35(19-21-37)29-6-4-5-7-30(29)38(43(2,41)42)24-26-8-9-26/h4-7,10-13,26-27H,3,8-9,14-24H2,1-2H3/t27-/m0/s1
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n/an/a 9.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138299
PNG
((S)-4-(4-Acetyl-piperazin-1-yl)-2-(4-chloro-benzyl...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C32H42ClN5O5S/c1-24(39)34-13-17-36(18-14-34)31(40)22-27(21-25-9-11-28(33)12-10-25)32(41)37-19-15-35(16-20-37)29-5-3-4-6-30(29)38(44(2,42)43)23-26-7-8-26/h3-6,9-12,26-27H,7-8,13-23H2,1-2H3/t27-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138304
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NCc1ccccc1F)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C34H40ClFN4O3/c1-4-40(25(3)41)24(2)30-10-6-8-12-32(30)38-17-19-39(20-18-38)34(43)28(21-26-13-15-29(35)16-14-26)22-33(42)37-23-27-9-5-7-11-31(27)36/h5-16,24,28H,4,17-23H2,1-3H3,(H,37,42)/t24?,28-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138300
PNG
(CHEMBL127861 | N-[1-(2-{4-[(S)-4-Azetidin-1-yl-2-(...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C30H39ClN4O3/c1-4-35(23(3)36)22(2)27-8-5-6-9-28(27)32-16-18-34(19-17-32)30(38)25(21-29(37)33-14-7-15-33)20-24-10-12-26(31)13-11-24/h5-6,8-13,22,25H,4,7,14-21H2,1-3H3/t22?,25-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138297
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NCc1ccccn1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C33H40ClN5O3/c1-4-39(25(3)40)24(2)30-10-5-6-11-31(30)37-17-19-38(20-18-37)33(42)27(21-26-12-14-28(34)15-13-26)22-32(41)36-23-29-9-7-8-16-35-29/h5-16,24,27H,4,17-23H2,1-3H3,(H,36,41)/t24?,27-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50223719
PNG
(CHEMBL3348530)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(O)=O |wU:22.22,58.61,36.38,4.3,wD:9.8,18.72,47.49,(-2.84,-13.67,;-1.44,-13.06,;-.19,-13.98,;1.22,-13.36,;2.45,-14.28,;2.29,-15.82,;3.87,-13.67,;5.11,-14.58,;4.05,-12.14,;5.46,-11.52,;6.26,-12.84,;7.39,-13.9,;6.5,-15.16,;8.75,-14.6,;10.25,-14.91,;11.79,-14.81,;13.26,-14.29,;14.51,-13.41,;15.48,-12.21,;16.1,-10.8,;16.3,-9.27,;17.84,-9.27,;16.1,-7.75,;17.58,-7.33,;18.66,-6.24,;18.4,-4.7,;19.77,-3.99,;20.87,-5.08,;22.4,-4.98,;23.27,-6.26,;22.57,-7.64,;21.03,-7.74,;20.17,-6.46,;15.48,-6.34,;14.51,-5.13,;15.56,-4.01,;13.26,-4.25,;13.95,-2.87,;15.49,-2.82,;16.21,-1.44,;17.75,-1.37,;18.45,-.01,;19.98,.06,;17.62,1.3,;11.79,-3.73,;10.25,-3.63,;10.16,-2.1,;8.75,-3.94,;8.23,-2.49,;9.23,-1.31,;10.76,-1.59,;11.76,-.43,;11.23,1.02,;9.72,1.3,;8.72,.13,;7.39,-4.66,;6.26,-5.7,;5.06,-4.73,;5.46,-7.02,;4.05,-6.4,;3.87,-4.87,;5.01,-3.84,;4.36,-2.43,;2.84,-2.61,;2.54,-4.11,;5.04,-8.51,;5.04,-10.04,;3.52,-10.25,;16.79,-13.01,;18.14,-12.28,;16.76,-14.55,)|
Show InChI InChI=1S/C48H66N14O9/c1-2-3-15-32(49)41(64)59-39-24-40(63)53-19-10-9-17-35(47(70)71)58-44(67)37(22-29-25-55-33-16-8-7-14-31(29)33)61-42(65)34(18-11-20-54-48(50)51)57-43(66)36(21-28-12-5-4-6-13-28)60-45(68)38(62-46(39)69)23-30-26-52-27-56-30/h4-8,12-14,16,25-27,32,34-39,55H,2-3,9-11,15,17-24,49H2,1H3,(H,52,56)(H,53,63)(H,57,66)(H,58,67)(H,59,64)(H,60,68)(H,61,65)(H,62,69)(H,70,71)(H4,50,51,54)/t32-,34-,35-,36+,37-,38-,39-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50134495
PNG
(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)c2ccccc12
Show InChI InChI=1S/C32H35ClN4O4S/c1-42(40,41)37-21-32(26-8-4-5-9-29(26)37)14-16-36(17-15-32)31(39)28(18-22-10-12-25(33)13-11-22)35-30(38)27-19-23-6-2-3-7-24(23)20-34-27/h2-13,27-28,34H,14-21H2,1H3,(H,35,38)/t27-,28-/m1/s1
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n/an/a 66n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138298
PNG
(CHEMBL338811 | Piperidine-4-carboxylic acid ((R)-1...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1CCNCC1
Show InChI InChI=1S/C30H40ClN5O4S/c1-41(39,40)36(21-23-6-7-23)28-5-3-2-4-27(28)34-16-18-35(19-17-34)30(38)26(20-22-8-10-25(31)11-9-22)33-29(37)24-12-14-32-15-13-24/h2-5,8-11,23-24,26,32H,6-7,12-21H2,1H3,(H,33,37)/t26-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50134495
PNG
(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)c2ccccc12
Show InChI InChI=1S/C32H35ClN4O4S/c1-42(40,41)37-21-32(26-8-4-5-9-29(26)37)14-16-36(17-15-32)31(39)28(18-22-10-12-25(33)13-11-22)35-30(38)27-19-23-6-2-3-7-24(23)20-34-27/h2-13,27-28,34H,14-21H2,1H3,(H,35,38)/t27-,28-/m1/s1
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n/an/a 153n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138295
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCNCC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C30H40ClN5O4S/c1-41(39,40)36(22-24-6-7-24)28-5-3-2-4-27(28)33-16-18-35(19-17-33)30(38)25(20-23-8-10-26(31)11-9-23)21-29(37)34-14-12-32-13-15-34/h2-5,8-11,24-25,32H,6-7,12-22H2,1H3/t25-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138296
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NC1CCC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C31H41ClN4O3/c1-4-36(23(3)37)22(2)28-10-5-6-11-29(28)34-16-18-35(19-17-34)31(39)25(20-24-12-14-26(32)15-13-24)21-30(38)33-27-8-7-9-27/h5-6,10-15,22,25,27H,4,7-9,16-21H2,1-3H3,(H,33,38)/t22?,25-/m0/s1
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n/an/a>600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138300
PNG
(CHEMBL127861 | N-[1-(2-{4-[(S)-4-Azetidin-1-yl-2-(...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C30H39ClN4O3/c1-4-35(23(3)36)22(2)27-8-5-6-9-28(27)32-16-18-34(19-17-32)30(38)25(21-29(37)33-14-7-15-33)20-24-10-12-26(31)13-11-24/h5-6,8-13,22,25H,4,7,14-21H2,1-3H3/t22?,25-/m0/s1
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n/an/a>1.40E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138304
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NCc1ccccc1F)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C34H40ClFN4O3/c1-4-40(25(3)41)24(2)30-10-6-8-12-32(30)38-17-19-39(20-18-38)34(43)28(21-26-13-15-29(35)16-14-26)22-33(42)37-23-27-9-5-7-11-31(27)36/h5-16,24,28H,4,17-23H2,1-3H3,(H,37,42)/t24?,28-/m0/s1
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n/an/a>1.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138293
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CC(C)(C)CC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C36H50ClN5O5S/c1-36(2,3)25-34(44)40-19-17-39(18-20-40)33(43)24-29(23-27-11-13-30(37)14-12-27)35(45)41-21-15-38(16-22-41)31-7-5-6-8-32(31)42(48(4,46)47)26-28-9-10-28/h5-8,11-14,28-29H,9-10,15-26H2,1-4H3/t29-/m0/s1
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n/an/a>1.80E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50134495
PNG
(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)c2ccccc12
Show InChI InChI=1S/C32H35ClN4O4S/c1-42(40,41)37-21-32(26-8-4-5-9-29(26)37)14-16-36(17-15-32)31(39)28(18-22-10-12-25(33)13-11-22)35-30(38)27-19-23-6-2-3-7-24(23)20-34-27/h2-13,27-28,34H,14-21H2,1H3,(H,35,38)/t27-,28-/m1/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138294
PNG
(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C35H48ClN5O6S/c1-35(2,3)47-34(44)40-21-17-38(18-22-40)32(42)24-28(23-26-11-13-29(36)14-12-26)33(43)39-19-15-37(16-20-39)30-7-5-6-8-31(30)41(48(4,45)46)25-27-9-10-27/h5-8,11-14,27-28H,9-10,15-25H2,1-4H3/t28-/m0/s1
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n/an/a>3.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138295
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCNCC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C30H40ClN5O4S/c1-41(39,40)36(22-24-6-7-24)28-5-3-2-4-27(28)33-16-18-35(19-17-33)30(38)25(20-23-8-10-26(31)11-9-23)21-29(37)34-14-12-32-13-15-34/h2-5,8-11,24-25,32H,6-7,12-22H2,1H3/t25-/m0/s1
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n/an/a>8.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138295
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCNCC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C30H40ClN5O4S/c1-41(39,40)36(22-24-6-7-24)28-5-3-2-4-27(28)33-16-18-35(19-17-33)30(38)25(20-23-8-10-26(31)11-9-23)21-29(37)34-14-12-32-13-15-34/h2-5,8-11,24-25,32H,6-7,12-22H2,1H3/t25-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138299
PNG
((S)-4-(4-Acetyl-piperazin-1-yl)-2-(4-chloro-benzyl...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C32H42ClN5O5S/c1-24(39)34-13-17-36(18-14-34)31(40)22-27(21-25-9-11-28(33)12-10-25)32(41)37-19-15-35(16-20-37)29-5-3-4-6-30(29)38(44(2,42)43)23-26-7-8-26/h3-6,9-12,26-27H,7-8,13-23H2,1-2H3/t27-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138292
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CCCN1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C33H46ClN5O4S/c1-3-14-35-15-17-37(18-16-35)32(40)24-28(23-26-10-12-29(34)13-11-26)33(41)38-21-19-36(20-22-38)30-6-4-5-7-31(30)39(44(2,42)43)25-27-8-9-27/h4-7,10-13,27-28H,3,8-9,14-25H2,1-2H3/t28-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138294
PNG
(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C35H48ClN5O6S/c1-35(2,3)47-34(44)40-21-17-38(18-22-40)32(42)24-28(23-26-11-13-29(36)14-12-26)33(43)39-19-15-37(16-20-39)30-7-5-6-8-31(30)41(48(4,45)46)25-27-9-10-27/h5-8,11-14,27-28H,9-10,15-25H2,1-4H3/t28-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50138288
PNG
(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C33H44ClN5O6S/c1-3-45-33(42)38-20-16-36(17-21-38)31(40)23-27(22-25-10-12-28(34)13-11-25)32(41)37-18-14-35(15-19-37)29-6-4-5-7-30(29)39(46(2,43)44)24-26-8-9-26/h4-7,10-13,26-27H,3,8-9,14-24H2,1-2H3/t27-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138299
PNG
((S)-4-(4-Acetyl-piperazin-1-yl)-2-(4-chloro-benzyl...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C32H42ClN5O5S/c1-24(39)34-13-17-36(18-14-34)31(40)22-27(21-25-9-11-28(33)12-10-25)32(41)37-19-15-35(16-20-37)29-5-3-4-6-30(29)38(44(2,42)43)23-26-7-8-26/h3-6,9-12,26-27H,7-8,13-23H2,1-2H3/t27-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138296
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NC1CCC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C31H41ClN4O3/c1-4-36(23(3)37)22(2)28-10-5-6-11-29(28)34-16-18-35(19-17-34)31(39)25(20-24-12-14-26(32)15-13-24)21-30(38)33-27-8-7-9-27/h5-6,10-15,22,25,27H,4,7-9,16-21H2,1-3H3,(H,33,38)/t22?,25-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138292
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CCCN1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C33H46ClN5O4S/c1-3-14-35-15-17-37(18-16-35)32(40)24-28(23-26-10-12-29(34)13-11-26)33(41)38-21-19-36(20-22-38)30-6-4-5-7-31(30)39(44(2,42)43)25-27-8-9-27/h4-7,10-13,27-28H,3,8-9,14-25H2,1-2H3/t28-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138304
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NCc1ccccc1F)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C34H40ClFN4O3/c1-4-40(25(3)41)24(2)30-10-6-8-12-32(30)38-17-19-39(20-18-38)34(43)28(21-26-13-15-29(35)16-14-26)22-33(42)37-23-27-9-5-7-11-31(27)36/h5-16,24,28H,4,17-23H2,1-3H3,(H,37,42)/t24?,28-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138288
PNG
(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C33H44ClN5O6S/c1-3-45-33(42)38-20-16-36(17-21-38)31(40)23-27(22-25-10-12-28(34)13-11-25)32(41)37-18-14-35(15-19-37)29-6-4-5-7-30(29)39(46(2,43)44)24-26-8-9-26/h4-7,10-13,26-27H,3,8-9,14-24H2,1-2H3/t27-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138293
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CC(C)(C)CC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C36H50ClN5O5S/c1-36(2,3)25-34(44)40-19-17-39(18-20-40)33(43)24-29(23-27-11-13-30(37)14-12-27)35(45)41-21-15-38(16-22-41)31-7-5-6-8-32(31)42(48(4,46)47)26-28-9-10-28/h5-8,11-14,28-29H,9-10,15-26H2,1-4H3/t29-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50138300
PNG
(CHEMBL127861 | N-[1-(2-{4-[(S)-4-Azetidin-1-yl-2-(...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C30H39ClN4O3/c1-4-35(23(3)36)22(2)27-8-5-6-9-28(27)32-16-18-34(19-17-32)30(38)25(21-29(37)33-14-7-15-33)20-24-10-12-26(31)13-11-24/h5-6,8-13,22,25H,4,7,14-21H2,1-3H3/t22?,25-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human melanocortin 3 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138294
PNG
(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C35H48ClN5O6S/c1-35(2,3)47-34(44)40-21-17-38(18-22-40)32(42)24-28(23-26-11-13-29(36)14-12-26)33(43)39-19-15-37(16-20-39)30-7-5-6-8-31(30)41(48(4,45)46)25-27-9-10-27/h5-8,11-14,27-28H,9-10,15-25H2,1-4H3/t28-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138290
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCN(CC2CC2)CC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C34H46ClN5O4S/c1-45(43,44)40(25-28-8-9-28)32-5-3-2-4-31(32)37-18-20-39(21-19-37)34(42)29(22-26-10-12-30(35)13-11-26)23-33(41)38-16-14-36(15-17-38)24-27-6-7-27/h2-5,10-13,27-29H,6-9,14-25H2,1H3/t29-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138304
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NCc1ccccc1F)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C34H40ClFN4O3/c1-4-40(25(3)41)24(2)30-10-6-8-12-32(30)38-17-19-39(20-18-38)34(43)28(21-26-13-15-29(35)16-14-26)22-33(42)37-23-27-9-5-7-11-31(27)36/h5-16,24,28H,4,17-23H2,1-3H3,(H,37,42)/t24?,28-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138288
PNG
(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C33H44ClN5O6S/c1-3-45-33(42)38-20-16-36(17-21-38)31(40)23-27(22-25-10-12-28(34)13-11-25)32(41)37-18-14-35(15-19-37)29-6-4-5-7-30(29)39(46(2,43)44)24-26-8-9-26/h4-7,10-13,26-27H,3,8-9,14-24H2,1-2H3/t27-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138297
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NCc1ccccn1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C33H40ClN5O3/c1-4-39(25(3)40)24(2)30-10-5-6-11-31(30)37-17-19-38(20-18-37)33(42)27(21-26-12-14-28(34)15-13-26)22-32(41)36-23-29-9-7-8-16-35-29/h5-16,24,27H,4,17-23H2,1-3H3,(H,36,41)/t24?,27-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138299
PNG
((S)-4-(4-Acetyl-piperazin-1-yl)-2-(4-chloro-benzyl...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C32H42ClN5O5S/c1-24(39)34-13-17-36(18-14-34)31(40)22-27(21-25-9-11-28(33)12-10-25)32(41)37-19-15-35(16-20-37)29-5-3-4-6-30(29)38(44(2,42)43)23-26-7-8-26/h3-6,9-12,26-27H,7-8,13-23H2,1-2H3/t27-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50134495
PNG
(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)c2ccccc12
Show InChI InChI=1S/C32H35ClN4O4S/c1-42(40,41)37-21-32(26-8-4-5-9-29(26)37)14-16-36(17-15-32)31(39)28(18-22-10-12-25(33)13-11-22)35-30(38)27-19-23-6-2-3-7-24(23)20-34-27/h2-13,27-28,34H,14-21H2,1H3,(H,35,38)/t27-,28-/m1/s1
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n/an/an/an/a 5.20n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138298
PNG
(CHEMBL338811 | Piperidine-4-carboxylic acid ((R)-1...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1CCNCC1
Show InChI InChI=1S/C30H40ClN5O4S/c1-41(39,40)36(21-23-6-7-23)28-5-3-2-4-27(28)34-16-18-35(19-17-34)30(38)26(20-22-8-10-25(31)11-9-22)33-29(37)24-12-14-32-15-13-24/h2-5,8-11,23-24,26,32H,6-7,12-21H2,1H3,(H,33,37)/t26-/m1/s1
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n/an/an/an/a<0.100n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138293
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CC(C)(C)CC(=O)N1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C36H50ClN5O5S/c1-36(2,3)25-34(44)40-19-17-39(18-20-40)33(43)24-29(23-27-11-13-30(37)14-12-27)35(45)41-21-15-38(16-22-41)31-7-5-6-8-32(31)42(48(4,46)47)26-28-9-10-28/h5-8,11-14,28-29H,9-10,15-26H2,1-4H3/t29-/m0/s1
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n/an/an/an/a 74n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138305
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CC(C)CCN1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C35H50ClN5O4S/c1-27(2)14-15-37-16-18-39(19-17-37)34(42)25-30(24-28-10-12-31(36)13-11-28)35(43)40-22-20-38(21-23-40)32-6-4-5-7-33(32)41(46(3,44)45)26-29-8-9-29/h4-7,10-13,27,29-30H,8-9,14-26H2,1-3H3/t30-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138296
PNG
((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)NC1CCC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C31H41ClN4O3/c1-4-36(23(3)37)22(2)28-10-5-6-11-29(28)34-16-18-35(19-17-34)31(39)25(20-24-12-14-26(32)15-13-24)21-30(38)33-27-8-7-9-27/h5-6,10-15,22,25,27H,4,7-9,16-21H2,1-3H3,(H,33,38)/t22?,25-/m0/s1
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n/an/an/an/a 15n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138303
PNG
((S)-4-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-benzy...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCN(CC1)C(=O)c1ccccc1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C37H44ClN5O5S/c1-49(47,48)43(27-29-11-12-29)34-10-6-5-9-33(34)39-17-21-42(22-18-39)37(46)31(25-28-13-15-32(38)16-14-28)26-35(44)40-19-23-41(24-20-40)36(45)30-7-3-2-4-8-30/h2-10,13-16,29,31H,11-12,17-27H2,1H3/t31-/m0/s1
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n/an/an/an/a 83n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50223719
PNG
(CHEMBL3348530)
Show SMILES CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(O)=O |wU:22.22,58.61,36.38,4.3,wD:9.8,18.72,47.49,(-2.84,-13.67,;-1.44,-13.06,;-.19,-13.98,;1.22,-13.36,;2.45,-14.28,;2.29,-15.82,;3.87,-13.67,;5.11,-14.58,;4.05,-12.14,;5.46,-11.52,;6.26,-12.84,;7.39,-13.9,;6.5,-15.16,;8.75,-14.6,;10.25,-14.91,;11.79,-14.81,;13.26,-14.29,;14.51,-13.41,;15.48,-12.21,;16.1,-10.8,;16.3,-9.27,;17.84,-9.27,;16.1,-7.75,;17.58,-7.33,;18.66,-6.24,;18.4,-4.7,;19.77,-3.99,;20.87,-5.08,;22.4,-4.98,;23.27,-6.26,;22.57,-7.64,;21.03,-7.74,;20.17,-6.46,;15.48,-6.34,;14.51,-5.13,;15.56,-4.01,;13.26,-4.25,;13.95,-2.87,;15.49,-2.82,;16.21,-1.44,;17.75,-1.37,;18.45,-.01,;19.98,.06,;17.62,1.3,;11.79,-3.73,;10.25,-3.63,;10.16,-2.1,;8.75,-3.94,;8.23,-2.49,;9.23,-1.31,;10.76,-1.59,;11.76,-.43,;11.23,1.02,;9.72,1.3,;8.72,.13,;7.39,-4.66,;6.26,-5.7,;5.06,-4.73,;5.46,-7.02,;4.05,-6.4,;3.87,-4.87,;5.01,-3.84,;4.36,-2.43,;2.84,-2.61,;2.54,-4.11,;5.04,-8.51,;5.04,-10.04,;3.52,-10.25,;16.79,-13.01,;18.14,-12.28,;16.76,-14.55,)|
Show InChI InChI=1S/C48H66N14O9/c1-2-3-15-32(49)41(64)59-39-24-40(63)53-19-10-9-17-35(47(70)71)58-44(67)37(22-29-25-55-33-16-8-7-14-31(29)33)61-42(65)34(18-11-20-54-48(50)51)57-43(66)36(21-28-12-5-4-6-13-28)60-45(68)38(62-46(39)69)23-30-26-52-27-56-30/h4-8,12-14,16,25-27,32,34-39,55H,2-3,9-11,15,17-24,49H2,1H3,(H,52,56)(H,53,63)(H,57,66)(H,58,67)(H,59,64)(H,60,68)(H,61,65)(H,62,69)(H,70,71)(H4,50,51,54)/t32-,34-,35-,36+,37-,38-,39-/m0/s1
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n/an/an/an/a<0.0100n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138295
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCNCC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C30H40ClN5O4S/c1-41(39,40)36(22-24-6-7-24)28-5-3-2-4-27(28)33-16-18-35(19-17-33)30(38)25(20-23-8-10-26(31)11-9-23)21-29(37)34-14-12-32-13-15-34/h2-5,8-11,24-25,32H,6-7,12-22H2,1H3/t25-/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138300
PNG
(CHEMBL127861 | N-[1-(2-{4-[(S)-4-Azetidin-1-yl-2-(...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C30H39ClN4O3/c1-4-35(23(3)36)22(2)27-8-5-6-9-28(27)32-16-18-34(19-17-32)30(38)25(21-29(37)33-14-7-15-33)20-24-10-12-26(31)13-11-24/h5-6,8-13,22,25H,4,7,14-21H2,1-3H3/t22?,25-/m0/s1
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n/an/an/an/a 340n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse melanocortin 1 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138301
PNG
(4-[(S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phen...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCN(CC1)C(=O)OC(C)(C)C)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C36H50ClN5O5/c1-7-42(27(3)43)26(2)31-10-8-9-11-32(31)38-16-20-40(21-17-38)34(45)29(24-28-12-14-30(37)15-13-28)25-33(44)39-18-22-41(23-19-39)35(46)47-36(4,5)6/h8-15,26,29H,7,16-25H2,1-6H3/t26?,29-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138291
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CCN1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C32H44ClN5O4S/c1-3-34-14-16-36(17-15-34)31(39)23-27(22-25-10-12-28(33)13-11-25)32(40)37-20-18-35(19-21-37)29-6-4-5-7-30(29)38(43(2,41)42)24-26-8-9-26/h4-7,10-13,26-27H,3,8-9,14-24H2,1-2H3/t27-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138302
PNG
(CHEMBL125079 | N-[1-(2-{4-[(S)-2-(4-Chloro-benzyl)...)
Show SMILES CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCSC1)Cc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1S/C30H39ClN4O3S/c1-4-35(23(3)36)22(2)27-7-5-6-8-28(27)32-13-15-33(16-14-32)30(38)25(19-24-9-11-26(31)12-10-24)20-29(37)34-17-18-39-21-34/h5-12,22,25H,4,13-21H2,1-3H3/t22?,25-/m0/s1
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n/an/an/an/a 530n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50138292
PNG
((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Show SMILES CCCN1CCN(CC1)C(=O)C[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1N(CC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C33H46ClN5O4S/c1-3-14-35-15-17-37(18-16-35)32(40)24-28(23-26-10-12-29(34)13-11-26)33(41)38-21-19-36(20-22-38)30-6-4-5-7-31(30)39(44(2,42)43)25-27-8-9-27/h4-7,10-13,27-28H,3,8-9,14-25H2,1-2H3/t28-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular level of cAMP in cells expressing the melanocortin 4 receptor

Bioorg Med Chem Lett 14: 377-81 (2003)


BindingDB Entry DOI: 10.7270/Q2902363
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%