Affinity Data by PubMed id=15006383

PubMed code 15006383

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
GABA-A receptor; alpha-5/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25877 (CHEMBL286594 \| RY-80, 1 \| ethyl 12-ethynyl-8-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha3-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-A receptor; alpha-5/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25879 (3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-A receptor; alpha-2/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25877 (CHEMBL286594 \| RY-80, 1 \| ethyl 12-ethynyl-8-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha4-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25877 (CHEMBL286594 \| RY-80, 1 \| ethyl 12-ethynyl-8-methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25877 (CHEMBL286594 \| RY-80, 1 \| ethyl 12-ethynyl-8-methy...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25877 (CHEMBL286594 \| RY-80, 1 \| ethyl 12-ethynyl-8-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA A receptor alpha-4/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25877 (CHEMBL286594 \| RY-80, 1 \| ethyl 12-ethynyl-8-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha3-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25879 (3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	858	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25879 (3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-A receptor; alpha-2/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25879 (3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA A receptor alpha-4/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25879 (3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2 (Homo sapiens (Human))	BDBM25879 (3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha4-beta3-gamma2 subunits expressed in L(tk-)cells				Bioorg Med Chem Lett 14: 1465-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.018 BindingDB Entry DOI: 10.7270/Q2W958M2
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%