Found 35 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149846
(2''-Amino-6''-(2-cyclopropylmethoxy-6-hydroxy-phen...)Show SMILES Nc1nc(cc(C2CCCNC2)c1C#N)-c1c(O)cccc1OCC1CC1 Show InChI InChI=1S/C21H24N4O2/c22-10-16-15(14-3-2-8-24-11-14)9-17(25-21(16)23)20-18(26)4-1-5-19(20)27-12-13-6-7-13/h1,4-5,9,13-14,24,26H,2-3,6-8,11-12H2,(H2,23,25) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149839
(2''-Amino-6''-(2-cyclobutylmethoxy-6-hydroxy-pheny...)Show SMILES Nc1nc(cc(C2CCCNC2)c1C#N)-c1c(O)cccc1OCC1CCC1 Show InChI InChI=1S/C22H26N4O2/c23-11-17-16(15-6-3-9-25-12-15)10-18(26-22(17)24)21-19(27)7-2-8-20(21)28-13-14-4-1-5-14/h2,7-8,10,14-15,25,27H,1,3-6,9,12-13H2,(H2,24,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149832
(2''-Amino-6''-(2-hydroxy-6-propoxy-phenyl)-1,2,3,4...)Show InChI InChI=1S/C20H24N4O2/c1-2-9-26-18-7-3-6-17(25)19(18)16-10-14(13-5-4-8-23-12-13)15(11-21)20(22)24-16/h3,6-7,10,13,23,25H,2,4-5,8-9,12H2,1H3,(H2,22,24) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149833
(2''-Amino-6''-(2-hydroxy-6-isobutoxy-phenyl)-1,2,3...)Show SMILES CC(C)COc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 Show InChI InChI=1S/C21H26N4O2/c1-13(2)12-27-19-7-3-6-18(26)20(19)17-9-15(14-5-4-8-24-11-14)16(10-22)21(23)25-17/h3,6-7,9,13-14,24,26H,4-5,8,11-12H2,1-2H3,(H2,23,25) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149838
(2''-Amino-6''-(2-hydroxy-6-pentyloxy-phenyl)-1,2,3...)Show SMILES CCCCCOc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 Show InChI InChI=1S/C22H28N4O2/c1-2-3-4-11-28-20-9-5-8-19(27)21(20)18-12-16(15-7-6-10-25-14-15)17(13-23)22(24)26-18/h5,8-9,12,15,25,27H,2-4,6-7,10-11,14H2,1H3,(H2,24,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149825
(2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-...)Show SMILES Nc1nc(cc(C2CCNCC2)c1C#N)-c1c(O)cccc1OCC1CC1 Show InChI InChI=1S/C21H24N4O2/c22-11-16-15(14-6-8-24-9-7-14)10-17(25-21(16)23)20-18(26)2-1-3-19(20)27-12-13-4-5-13/h1-3,10,13-14,24,26H,4-9,12H2,(H2,23,25) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149843
(2''-Amino-6''-(2-benzyloxy-6-hydroxy-phenyl)-1,2,3...)Show SMILES Nc1nc(cc(C2CCCNC2)c1C#N)-c1c(O)cccc1OCc1ccccc1 Show InChI InChI=1S/C24H24N4O2/c25-13-19-18(17-8-5-11-27-14-17)12-20(28-24(19)26)23-21(29)9-4-10-22(23)30-15-16-6-2-1-3-7-16/h1-4,6-7,9-10,12,17,27,29H,5,8,11,14-15H2,(H2,26,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149828
(2-Amino-6-(2-cyclobutylmethoxy-6-hydroxy-phenyl)-1...)Show SMILES Nc1nc(cc(C2CCNCC2)c1C#N)-c1c(O)cccc1OCC1CCC1 Show InChI InChI=1S/C22H26N4O2/c23-12-17-16(15-7-9-25-10-8-15)11-18(26-22(17)24)21-19(27)5-2-6-20(21)28-13-14-3-1-4-14/h2,5-6,11,14-15,25,27H,1,3-4,7-10,13H2,(H2,24,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149831
(2''-Amino-6''-(2-heptyloxy-6-hydroxy-phenyl)-1,2,3...)Show SMILES CCCCCCCOc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 Show InChI InChI=1S/C24H32N4O2/c1-2-3-4-5-6-13-30-22-11-7-10-21(29)23(22)20-14-18(17-9-8-12-27-16-17)19(15-25)24(26)28-20/h7,10-11,14,17,27,29H,2-6,8-9,12-13,16H2,1H3,(H2,26,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149852
(2''-Amino-6''-(2-ethoxy-6-hydroxy-phenyl)-1,2,3,4,...)Show InChI InChI=1S/C19H22N4O2/c1-2-25-17-7-3-6-16(24)18(17)15-9-13(12-5-4-8-22-11-12)14(10-20)19(21)23-15/h3,6-7,9,12,22,24H,2,4-5,8,11H2,1H3,(H2,21,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149850
(2-Amino-6-(2-butoxy-6-hydroxy-phenyl)-1'',2'',3'',...)Show SMILES CCCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 Show InChI InChI=1S/C21H26N4O2/c1-2-3-11-27-19-6-4-5-18(26)20(19)17-12-15(14-7-9-24-10-8-14)16(13-22)21(23)25-17/h4-6,12,14,24,26H,2-3,7-11H2,1H3,(H2,23,25) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149842
(2''-Amino-6''-(2,6-dihydroxy-phenyl)-1,2,3,4,5,6-h...)Show InChI InChI=1S/C17H18N4O2/c18-8-12-11(10-3-2-6-20-9-10)7-13(21-17(12)19)16-14(22)4-1-5-15(16)23/h1,4-5,7,10,20,22-23H,2-3,6,9H2,(H2,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149837
(2-Amino-6-(2-hydroxy-6-isobutoxy-phenyl)-1'',2'',3...)Show SMILES CC(C)COc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 Show InChI InChI=1S/C21H26N4O2/c1-13(2)12-27-19-5-3-4-18(26)20(19)17-10-15(14-6-8-24-9-7-14)16(11-22)21(23)25-17/h3-5,10,13-14,24,26H,6-9,12H2,1-2H3,(H2,23,25) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149826
(2-Amino-6-(2-hydroxy-6-pentyloxy-phenyl)-1'',2'',3...)Show SMILES CCCCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 Show InChI InChI=1S/C22H28N4O2/c1-2-3-4-12-28-20-7-5-6-19(27)21(20)18-13-16(15-8-10-25-11-9-15)17(14-23)22(24)26-18/h5-7,13,15,25,27H,2-4,8-12H2,1H3,(H2,24,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149840
(2-Amino-6-(2-hydroxy-6-propoxy-phenyl)-1'',2'',3''...)Show InChI InChI=1S/C20H24N4O2/c1-2-10-26-18-5-3-4-17(25)19(18)16-11-14(13-6-8-23-9-7-13)15(12-21)20(22)24-16/h3-5,11,13,23,25H,2,6-10H2,1H3,(H2,22,24) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149834
(2-Amino-6-(2-hexyloxy-6-hydroxy-phenyl)-1'',2'',3'...)Show SMILES CCCCCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 Show InChI InChI=1S/C23H30N4O2/c1-2-3-4-5-13-29-21-8-6-7-20(28)22(21)19-14-17(16-9-11-26-12-10-16)18(15-24)23(25)27-19/h6-8,14,16,26,28H,2-5,9-13H2,1H3,(H2,25,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149806
(2''-Amino-6''-(2-hydroxy-phenyl)-1,2,3,4,5,6-hexah...)Show InChI InChI=1S/C17H18N4O/c18-9-14-13(11-4-3-7-20-10-11)8-15(21-17(14)19)12-5-1-2-6-16(12)22/h1-2,5-6,8,11,20,22H,3-4,7,10H2,(H2,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149835
(2''-Amino-6''-(2-cyclohexylmethoxy-6-hydroxy-pheny...)Show SMILES Nc1nc(cc(C2CCCNC2)c1C#N)-c1c(O)cccc1OCC1CCCCC1 Show InChI InChI=1S/C24H30N4O2/c25-13-19-18(17-8-5-11-27-14-17)12-20(28-24(19)26)23-21(29)9-4-10-22(23)30-15-16-6-2-1-3-7-16/h4,9-10,12,16-17,27,29H,1-3,5-8,11,14-15H2,(H2,26,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149836
(2''-Amino-6''-(2-hydroxy-6-methoxy-phenyl)-1,2,3,4...)Show InChI InChI=1S/C18H20N4O2/c1-24-16-6-2-5-15(23)17(16)14-8-12(11-4-3-7-21-10-11)13(9-19)18(20)22-14/h2,5-6,8,11,21,23H,3-4,7,10H2,1H3,(H2,20,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149830
(2-Amino-6-(2-heptyloxy-6-hydroxy-phenyl)-1'',2'',3...)Show SMILES CCCCCCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 Show InChI InChI=1S/C24H32N4O2/c1-2-3-4-5-6-14-30-22-9-7-8-21(29)23(22)20-15-18(17-10-12-27-13-11-17)19(16-25)24(26)28-20/h7-9,15,17,27,29H,2-6,10-14H2,1H3,(H2,26,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149815
(2-Amino-4-(1-amino-2-phenyl-ethyl)-6-(2-hydroxy-ph...)Show InChI InChI=1S/C20H18N4O/c21-12-16-15(17(22)10-13-6-2-1-3-7-13)11-18(24-20(16)23)14-8-4-5-9-19(14)25/h1-9,11,17,25H,10,22H2,(H2,23,24) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149851
(2''-Amino-6''-(2-hydroxy-6-isopropoxy-phenyl)-1,2,...)Show SMILES CC(C)Oc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 Show InChI InChI=1S/C20H24N4O2/c1-12(2)26-18-7-3-6-17(25)19(18)16-9-14(13-5-4-8-23-11-13)15(10-21)20(22)24-16/h3,6-7,9,12-13,23,25H,4-5,8,11H2,1-2H3,(H2,22,24) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149848
(2-Amino-6-(2-benzyloxy-6-hydroxy-phenyl)-1'',2'',3...)Show SMILES Nc1nc(cc(C2CCNCC2)c1C#N)-c1c(O)cccc1OCc1ccccc1 Show InChI InChI=1S/C24H24N4O2/c25-14-19-18(17-9-11-27-12-10-17)13-20(28-24(19)26)23-21(29)7-4-8-22(23)30-15-16-5-2-1-3-6-16/h1-8,13,17,27,29H,9-12,15H2,(H2,26,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149841
(2-Amino-6-(2-ethoxy-6-hydroxy-phenyl)-1'',2'',3'',...)Show InChI InChI=1S/C19H22N4O2/c1-2-25-17-5-3-4-16(24)18(17)15-10-13(12-6-8-22-9-7-12)14(11-20)19(21)23-15/h3-5,10,12,22,24H,2,6-9H2,1H3,(H2,21,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit alpha
(Homo sapiens (Human)) | BDBM50149825
(2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-...)Show SMILES Nc1nc(cc(C2CCNCC2)c1C#N)-c1c(O)cccc1OCC1CC1 Show InChI InChI=1S/C21H24N4O2/c22-11-16-15(14-6-8-24-9-7-14)10-17(25-21(16)23)20-18(26)2-1-3-19(20)27-12-13-4-5-13/h1-3,10,13-14,24,26H,4-9,12H2,(H2,23,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of I-kappa-B-kinase alpha |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149829
(2-Amino-6-(2,6-dihydroxy-phenyl)-1'',2'',3'',4'',5...)Show InChI InChI=1S/C17H18N4O2/c18-9-12-11(10-4-6-20-7-5-10)8-13(21-17(12)19)16-14(22)2-1-3-15(16)23/h1-3,8,10,20,22-23H,4-7H2,(H2,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149810
(2-Amino-6-(2-hydroxy-phenyl)-1'',2'',3'',4'',5'',6...)Show InChI InChI=1S/C17H18N4O/c18-10-14-13(11-5-7-20-8-6-11)9-15(21-17(14)19)12-3-1-2-4-16(12)22/h1-4,9,11,20,22H,5-8H2,(H2,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149847
(2''-Amino-6''-(2-hydroxy-4-methoxy-phenyl)-1,2,3,4...)Show InChI InChI=1S/C18H20N4O2/c1-24-12-4-5-13(17(23)7-12)16-8-14(11-3-2-6-21-10-11)15(9-19)18(20)22-16/h4-5,7-8,11,21,23H,2-3,6,10H2,1H3,(H2,20,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149827
(2''-Amino-6''-(2-hydroxy-3-methyl-phenyl)-1,2,3,4,...)Show InChI InChI=1S/C18H20N4O/c1-11-4-2-6-13(17(11)23)16-8-14(12-5-3-7-21-10-12)15(9-19)18(20)22-16/h2,4,6,8,12,21,23H,3,5,7,10H2,1H3,(H2,20,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50124313
(5-Oxo-tetrahydro-furan-2-carboxylic acid {3-[2-ami...)Show SMILES Nc1nc(cc(-c2cccc(NC(=O)C3CCC(=O)O3)c2)c1C#N)-c1ccccc1O Show InChI InChI=1S/C23H18N4O4/c24-12-17-16(11-18(27-22(17)25)15-6-1-2-7-19(15)28)13-4-3-5-14(10-13)26-23(30)20-8-9-21(29)31-20/h1-7,10-11,20,28H,8-9H2,(H2,25,27)(H,26,30) | PDB
NCI pathway
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149844
(2''-Amino-6''-(2-hydroxy-6-methyl-phenyl)-1,2,3,4,...)Show InChI InChI=1S/C18H20N4O/c1-11-4-2-6-16(23)17(11)15-8-13(12-5-3-7-21-10-12)14(9-19)18(20)22-15/h2,4,6,8,12,21,23H,3,5,7,10H2,1H3,(H2,20,22) | PDB
NCI pathway
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149849
(2''-Amino-6''-(2-amino-6-hydroxy-phenyl)-1,2,3,4,5...)Show InChI InChI=1S/C17H19N5O/c18-8-12-11(10-3-2-6-21-9-10)7-14(22-17(12)20)16-13(19)4-1-5-15(16)23/h1,4-5,7,10,21,23H,2-3,6,9,19H2,(H2,20,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
(Homo sapiens (Human)) | BDBM50149825
(2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-...)Show SMILES Nc1nc(cc(C2CCNCC2)c1C#N)-c1c(O)cccc1OCC1CC1 Show InChI InChI=1S/C21H24N4O2/c22-11-16-15(14-6-8-24-9-7-14)10-17(25-21(16)23)20-18(26)2-1-3-19(20)27-12-13-4-5-13/h1-3,10,13-14,24,26H,4-9,12H2,(H2,23,25) | Reactome pathway
KEGG
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CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of I-kappa-B-kinase 3 |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50149845
(2''-Amino-6''-(2-hydroxy-3-methoxy-phenyl)-1,2,3,4...)Show InChI InChI=1S/C18H20N4O2/c1-24-16-6-2-5-12(17(16)23)15-8-13(11-4-3-7-21-10-11)14(9-19)18(20)22-15/h2,5-6,8,11,21,23H,3-4,7,10H2,1H3,(H2,20,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta) |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50149825
(2-Amino-6-(2-cyclopropylmethoxy-6-hydroxy-phenyl)-...)Show SMILES Nc1nc(cc(C2CCNCC2)c1C#N)-c1c(O)cccc1OCC1CC1 Show InChI InChI=1S/C21H24N4O2/c22-11-16-15(14-6-8-24-9-7-14)10-17(25-21(16)23)20-18(26)2-1-3-19(20)27-12-13-4-5-13/h1-3,10,13-14,24,26H,4-9,12H2,(H2,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216
Curated by ChEMBL
| Assay Description
Inhibition of Syk protein tyrosine kinase |
Bioorg Med Chem Lett 14: 4019-22 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.041
BindingDB Entry DOI: 10.7270/Q2JM293M |
More data for this
Ligand-Target Pair | |
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