Found 29 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
High binding affinity towards human D2 dopamine receptor was determined by using [3H]YM-09151-2 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2A receptor was determined by using [3H]-ketanserin as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2A receptor was determined by using [3H]-ketanserin as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D3 dopamine receptor was determined by using [3H]YM-09151-2 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D3 dopamine receptor was determined by using [3H]YM-09151-2 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human 5-hydroxytryptamine 1A receptor was determined by using [3H]8-OH-DPAT as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human 5-hydroxytryptamine 1A receptor was determined by using [3H]8-OH-DPAT as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D3 dopamine receptor was determined by using [3H]YM-09151-2 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D3 dopamine receptor was determined by using [3H]YM-09151-2 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2C receptor was determined by using [3H]mesulergine as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2C receptor was determined by using [3H]mesulergine as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 304 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D2 dopamine receptor was determined by using [3H]YM-09151-2 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 317 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 317 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 395 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human 5-hydroxytryptamine 1A receptor was determined by using [3H]8-OH-DPAT as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 395 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human 5-hydroxytryptamine 1A receptor was determined by using [3H]8-OH-DPAT as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2C receptor was determined by using [3H]mesulergine as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2C receptor was determined by using [3H]mesulergine as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 414 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2A receptor was determined by using [3H]-ketanserin as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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PubMed
| 414 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2A receptor was determined by using [3H]-ketanserin as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 1.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Low binding affinity towards human D2 dopamine receptor was determined by using [3H]YM-09151-2 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 1.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| 1.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Concentration required to inhibit [3H]YM-09151-2 binding to human D2 dopamine receptor |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Concentration required to inhibit [3H]YM-09151-2 binding to human D2 dopamine receptor |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Antgonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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PubMed
| n/a | n/a | 837 | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Concentration required to inhibit [3H]YM-09151-2 binding to human D2 dopamine receptor |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
Reactome pathway
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PubMed
| n/a | n/a | 837 | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Concentration required to inhibit [3H]YM-09151-2 binding to human D2 dopamine receptor |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50370414
(CHEMBL611207 | MESORIDAZINE)Show SMILES CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc(cc12)[S@](C)=O |r,@:1| Show InChI InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-,26+/m1/s1 | PDB
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| n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham& Women's Hospital
Curated by ChEMBL
| Assay Description
Antgonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay |
Bioorg Med Chem Lett 14: 4379-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.078
BindingDB Entry DOI: 10.7270/Q2NZ88DW |
More data for this
Ligand-Target Pair | |
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