Affinity Data by PubMed id=15857150

PubMed code 15857150

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10237 (6-chloro-1-[(2,6-difluorophenyl)methyl]-2,3-dihydr...) Show SMILES Fc1cccc(F)c1Cn1c2cc(Cl)ccc2[nH]c1=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10243 (6-chloro-1-(naphthalen-2-ylmethyl)-2,3-dihydro-1H-...) Show SMILES Clc1ccc2[nH]c(=O)n(Cc3ccc4ccccc4c3)c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10240 (6-chloro-1-[(2,6-dichlorophenyl)methyl]-2,3-dihydr...) Show SMILES Clc1ccc2[nH]c(=O)n(Cc3c(Cl)cccc3Cl)c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10242 (6-chloro-1-(naphthalen-1-ylmethyl)-2,3-dihydro-1H-...) Show SMILES Clc1ccc2[nH]c(=O)n(Cc3cccc4ccccc34)c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10241 (6-chloro-1-{[4-(propan-2-yl)phenyl]methyl}-2,3-dih...) Show SMILES CC(C)c1ccc(Cn2c3cc(Cl)ccc3[nH]c2=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10239 (5-chloro-3-[(2,6-difluorophenyl)methyl]-2,3-dihydr...) Show SMILES Fc1cccc(F)c1Cn1c2cc(Cl)ccc2oc1=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10245 (3-(2,6-difluorophenyl)-4-thia-2,7-diazatricyclo[6....) Show SMILES Fc1cccc(F)c1C1SCc2nc3ccccc3n12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.46E+4	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10244 (6-chloro-1-(cyclohexylmethyl)-2,3-dihydro-1H-1,3-b...) Show SMILES Clc1ccc2[nH]c(=O)n(CC3CCCCC3)c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM10238 (5-chloro-1-[(2,6-difluorophenyl)methyl]-2,3-dihydr...) Show SMILES Fc1cccc(F)c1Cn1c2ccc(Cl)cc2[nH]c1=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	7.5	37
Universita di Messina					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 48: 3433-7 (2005) Article DOI: 10.1021/jm049279a BindingDB Entry DOI: 10.7270/Q27D2SC4
Universita di Messina					More data for this Ligand-Target Pair

* indicates data uncertainty>20%