Found 8 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Plasminogen activator inhibitor 1
(Homo sapiens (Human)) | BDBM50149275
(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)Show SMILES OC(=O)C(=O)c1cn(Cc2ccccc2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C24H16F3NO4/c25-24(26,27)32-18-9-6-16(7-10-18)17-8-11-21-19(12-17)20(22(29)23(30)31)14-28(21)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay |
Bioorg Med Chem Lett 15: 3514-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.095
BindingDB Entry DOI: 10.7270/Q2KH0MVQ |
More data for this
Ligand-Target Pair | |
Plasminogen activator inhibitor 1
(Homo sapiens (Human)) | BDBM50169448
(1-Benzyl-3-phenyl-5-(4-trifluoromethoxy-benzenesul...)Show SMILES OC(=O)c1c(-c2ccccc2)c2cc(NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)ccc2n1Cc1ccccc1 Show InChI InChI=1S/C29H21F3N2O5S/c30-29(31,32)39-22-12-14-23(15-13-22)40(37,38)33-21-11-16-25-24(17-21)26(20-9-5-2-6-10-20)27(28(35)36)34(25)18-19-7-3-1-4-8-19/h1-17,33H,18H2,(H,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay |
Bioorg Med Chem Lett 15: 3514-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.095
BindingDB Entry DOI: 10.7270/Q2KH0MVQ |
More data for this
Ligand-Target Pair | |
Plasminogen activator inhibitor 1
(Homo sapiens (Human)) | BDBM50169451
(1-Biphenyl-4-ylmethyl-5-(4-tert-butyl-phenylamino)...)Show SMILES CC(C)(C)c1ccc(Nc2ccc3n(Cc4ccc(cc4)-c4ccccc4)c(C(O)=O)c(-c4ccccc4)c3c2)cc1 Show InChI InChI=1S/C38H34N2O2/c1-38(2,3)30-18-20-31(21-19-30)39-32-22-23-34-33(24-32)35(29-12-8-5-9-13-29)36(37(41)42)40(34)25-26-14-16-28(17-15-26)27-10-6-4-7-11-27/h4-24,39H,25H2,1-3H3,(H,41,42) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay |
Bioorg Med Chem Lett 15: 3514-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.095
BindingDB Entry DOI: 10.7270/Q2KH0MVQ |
More data for this
Ligand-Target Pair | |
Plasminogen activator inhibitor 1
(Homo sapiens (Human)) | BDBM50149274
(2-[4-(3,4-Dichloro-phenylcarbamoyl)-benzylamino]-4...)Show SMILES OC(=O)c1ccc(cc1NCc1ccc(cc1)C(=O)Nc1ccc(Cl)c(Cl)c1)[N+]([O-])=O Show InChI InChI=1S/C21H15Cl2N3O5/c22-17-8-5-14(9-18(17)23)25-20(27)13-3-1-12(2-4-13)11-24-19-10-15(26(30)31)6-7-16(19)21(28)29/h1-10,24H,11H2,(H,25,27)(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.78E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay |
Bioorg Med Chem Lett 15: 3514-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.095
BindingDB Entry DOI: 10.7270/Q2KH0MVQ |
More data for this
Ligand-Target Pair | |
Plasminogen activator inhibitor 1
(Homo sapiens (Human)) | BDBM50169446
(1-Benzyl-5-(biphenyl-4-sulfonylamino)-3-phenyl-1H-...)Show SMILES OC(=O)c1c(-c2ccccc2)c2cc(NS(=O)(=O)c3ccc(cc3)-c3ccccc3)ccc2n1Cc1ccccc1 Show InChI InChI=1S/C34H26N2O4S/c37-34(38)33-32(27-14-8-3-9-15-27)30-22-28(18-21-31(30)36(33)23-24-10-4-1-5-11-24)35-41(39,40)29-19-16-26(17-20-29)25-12-6-2-7-13-25/h1-22,35H,23H2,(H,37,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay |
Bioorg Med Chem Lett 15: 3514-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.095
BindingDB Entry DOI: 10.7270/Q2KH0MVQ |
More data for this
Ligand-Target Pair | |
Plasminogen activator inhibitor 1
(Homo sapiens (Human)) | BDBM50169450
(5-Benzenesulfonylamino-1-biphenyl-4-ylmethyl-3-phe...)Show SMILES OC(=O)c1c(-c2ccccc2)c2cc(NS(=O)(=O)c3ccccc3)ccc2n1Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C34H26N2O4S/c37-34(38)33-32(27-12-6-2-7-13-27)30-22-28(35-41(39,40)29-14-8-3-9-15-29)20-21-31(30)36(33)23-24-16-18-26(19-17-24)25-10-4-1-5-11-25/h1-22,35H,23H2,(H,37,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay |
Bioorg Med Chem Lett 15: 3514-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.095
BindingDB Entry DOI: 10.7270/Q2KH0MVQ |
More data for this
Ligand-Target Pair | |
Plasminogen activator inhibitor 1
(Homo sapiens (Human)) | BDBM50169447
(1-Benzyl-5-(4-tert-butyl-benzenesulfonylamino)-3-p...)Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc2n(Cc3ccccc3)c(C(O)=O)c(-c3ccccc3)c2c1 Show InChI InChI=1S/C32H30N2O4S/c1-32(2,3)24-14-17-26(18-15-24)39(37,38)33-25-16-19-28-27(20-25)29(23-12-8-5-9-13-23)30(31(35)36)34(28)21-22-10-6-4-7-11-22/h4-20,33H,21H2,1-3H3,(H,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.87E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay |
Bioorg Med Chem Lett 15: 3514-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.095
BindingDB Entry DOI: 10.7270/Q2KH0MVQ |
More data for this
Ligand-Target Pair | |
Plasminogen activator inhibitor 1
(Homo sapiens (Human)) | BDBM50169449
(1-Benzyl-5-(biphenyl-4-sulfonylamino)-1H-indole-2-...)Show SMILES OC(=O)c1cc2cc(NS(=O)(=O)c3ccc(cc3)-c3ccccc3)ccc2n1Cc1ccccc1 Show InChI InChI=1S/C28H22N2O4S/c31-28(32)27-18-23-17-24(13-16-26(23)30(27)19-20-7-3-1-4-8-20)29-35(33,34)25-14-11-22(12-15-25)21-9-5-2-6-10-21/h1-18,29H,19H2,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay |
Bioorg Med Chem Lett 15: 3514-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.095
BindingDB Entry DOI: 10.7270/Q2KH0MVQ |
More data for this
Ligand-Target Pair | |
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