Affinity Data by PubMed id=16125383

PubMed code 16125383

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6088 (7-[(2,4-Dichloro-5-methoxyphenyl)amino]-2-{5-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6457 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{5-[(dim...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6451 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{5-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6454 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{5-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6458 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{5-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6092 (7-[(2,4-Dichloro-5-methoxyphenyl)amino]-2-{5-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6459 (7-[(2,4-dichlorophenyl)amino]-2-{5-[(4-methylpiper...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6455 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{6-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6452 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{5-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6453 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-{2-[(4-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6448 (7-{[(2,4-dichlorophenyl)methyl]amino}-2-{4-[(4-met...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6456 (7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-[3-(4-me...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...				Bioorg Med Chem Lett 15: 4681-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.061 BindingDB Entry DOI: 10.7270/Q23J3B44
Wyeth Research					More data for this Ligand-Target Pair

* indicates data uncertainty>20%