Affinity Data by PubMed id=16530412

PubMed code 16530412

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM50184279 (1-benzyl-3-(4-morpholinophenylamino)pyrrolidine-2,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM32184 (CHEMBL209511 \| N-(4-chloranyl-2-oxidanyl-phenyl)be...) Show SMILES Oc1cc(Cl)ccc1NS(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM55151 (1-(3,4-Dihydroxy-phenyl)-2-(4-hydroxy-6-methyl-pyr...) Show SMILES Cc1cc(=O)[nH]c(SCC(=O)c2ccc(O)c(O)c2)n1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM50184280 (CHEMBL385134 \| N-(4-hydroxy-3-methylphenyl)-3-meth...) Show SMILES COc1cccc(c1)C(=O)Nc1ccc(O)c(C)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM50184276 (3-(1-hydroxy-3,3-dimethyl-3,4,10,11-tetrahydro-2H-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM50184282 (4-methoxy-2-(3-(thiophen-2-yl)-1H-pyrazol-4-yl)phe...) Show SMILES COc1ccc(O)c(c1)-c1c[nH]nc1-c1cccs1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM50184281 (3-(4-fluorophenoxy)-7,8-dihydroxy-4H-chromen-4-one...) Show SMILES Oc1ccc2c(occ(Oc3ccc(F)cc3)c2=O)c1O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM50184283 (1-(3-chlorophenyl)pyrazolidine-3,5-dione \| CHEMBL2...) Show SMILES Oc1cc(=O)[nH]n1-c1cccc(Cl)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM32185 (6-[5-(3-methoxy-4-oxidanyl-phenyl)pyrazolidin-3-yl...) Show SMILES COc1cc(ccc1O)C1CC(N=N1)c1ccccc1O \|c:13\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha/90-beta (Homo sapiens (Human))	BDBM50184278 (CHEMBL380370 \| N-(4-(2-amino-4-methylthiazol-5-yl)...) Show SMILES Cc1nc(N)sc1-c1csc(Nc2ccccn2)n1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Hsp90 by recombinant ATPase assay				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM32185 (6-[5-(3-methoxy-4-oxidanyl-phenyl)pyrazolidin-3-yl...) Show SMILES COc1cc(ccc1O)C1CC(N=N1)c1ccccc1O \|c:13\| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Her2 in SKBr3 cells by ELISA				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM32184 (CHEMBL209511 \| N-(4-chloranyl-2-oxidanyl-phenyl)be...) Show SMILES Oc1cc(Cl)ccc1NS(=O)(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Her2 in SKBr3 cells by ELISA				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50184276 (3-(1-hydroxy-3,3-dimethyl-3,4,10,11-tetrahydro-2H-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Inhibition of Her2 in SKBr3 cells by ELISA				Bioorg Med Chem Lett 16: 3005-8 (2006) Article DOI: 10.1016/j.bmcl.2006.02.063 BindingDB Entry DOI: 10.7270/Q2W37VXT
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%