Affinity Data by PubMed id=16574416

PubMed code 16574416

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14818 (2-{[7-(carboxymethoxy)-9-(hydroxyimino)-9H-fluoren...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14823 (2-[(6-amino-9H-purin-8-yl)sulfanyl]acetamide \| Asi...) Show SMILES NC(=O)CSc1nc2ncnc(N)c2[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14815 (InterBioScreen compound 2 \| N-(3-aminopropyl)-5-ch...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14822 (4-[3-(4-amino-1,2,5-oxadiazol-3-yl)-1-propyl-1H-1,...) Show SMILES CCCn1nc(nc1-c1nonc1N)-c1nonc1N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	1.73E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14819 ((1E)-1-[(6-chloro-2H-1,3-benzodioxol-5-yl)methylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.01E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14816 (6-amino-4-(3,4-dihydroxyphenyl)-3-methyl-1H,4H-pyr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.04E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14817 (4-{[5-(5-chloro-2-methoxyphenyl)-1,3,4-thiadiazol-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.66E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14821 ((2S)-1-amino-3-[(5-nitroquinolin-8-yl)amino]propan...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	2.73E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14814 (2-[(6-amino-9H-purin-8-yl)sulfanyl]acetic acid \| A...) Show SMILES Nc1ncnc2nc(SCC(O)=O)[nH]c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.18E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14820 (3-amino-5-[(3Z)-5-nitro-2-oxo-2,3-dihydro-1H-indol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.27E+4	n/a	n/a	n/a	n/a	7.5	30
Vernalis (R&D) Ltd					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....				Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair

* indicates data uncertainty>20%