Affinity Data by PubMed id=16899369

PubMed code 16899369

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29018 ((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	1.49E+5	1.54E+5	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair				3D Structure (crystal)
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29018 ((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	1.49E+5	n/a	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair				3D Structure (crystal)
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29017 ((1S,5S,7R)-N-hydroxy-3-[(4-phenylphenyl)methyl]-6,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.99E+5	>5.00E+5	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29016 ((1R,5S,7R)-N-hydroxy-2-oxo-3-[(4-phenylphenyl)meth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.25E+5	>5.00E+5	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM29018 ((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	5.13E+5	n/a	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM29018 ((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	7.78E+5	n/a	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29015 ((1S,5S,7R)-3-[(4-phenylphenyl)methyl]-6,8-dioxa-3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.35E+5	>1.00E+6	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Stromelysin-2 (Homo sapiens (Human))	BDBM29018 ((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	8.65E+5	n/a	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29014 ((1R,5S,7R)-2-oxo-3-[(4-phenylphenyl)methyl]-6,8-di...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.54E+5	>1.00E+6	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM29018 ((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.18E+6	n/a	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Matrilysin (Homo sapiens (Human))	BDBM29018 ((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.51E+6	n/a	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29022 (ethyl 1-(hydroxycarbamoyl)piperidine-4-carboxylate...) Show SMILES CCOC(=O)C1CCN(CC1)C(=O)NO Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.40E+6	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29020 ((1S,5S,7R)-3-benzyl-6,8-dioxa-3-azabicyclo[3.2.1]o...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>1.00E+7	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29021 ((1R,5S,7R)-3-benzyl-N-hydroxy-2-oxo-6,8-dioxa-3-az...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>1.00E+7	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29023 ((1S,5R)-3-[(4-phenylphenyl)methyl]-6,8-dioxa-3-aza...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29019 ((1R,5S,7R)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>1.00E+7	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair

* indicates data uncertainty>20%