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PubMed code 16916797

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein phosphatase non-receptor type 1 [1-298]


(Homo sapiens (Human))		BDBM13809
PNG
((2S)-N-[(1S)-1-carbamoyl-2-[4-(1,1,3-trioxo-2,3-di...)
Show SMILES NC(=O)[C@H](Cc1ccc(cc1)C1=CC(=O)NS1(=O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(cc1)C1=CC(=O)NS1(=O)=O |r,t:12,44|
Show InChI InChI=1S/C32H29N5O9S2/c33-31(41)24(14-20-6-10-22(11-7-20)26-17-29(39)36-47(26,43)44)35-32(42)25(15-19-4-2-1-3-5-19)34-28(38)16-21-8-12-23(13-9-21)27-18-30(40)37-48(27,45)46/h1-13,17-18,24-25H,14-16H2,(H2,33,41)(H,34,38)(H,35,42)(H,36,39)(H,37,40)/t24-,25-/m0/s1
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n/an/a 65n/an/an/an/a7.022



Incyte Corporation



Assay Description
The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...

J Biol Chem 281: 32784-95 (2006)


Article DOI: 10.1074/jbc.M606873200
BindingDB Entry DOI: 10.7270/Q2GX48SD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 [1-298]


(Homo sapiens (Human))		BDBM13808
PNG
((2S)-N-[(1S)-1-carbamoyl-2-[4-(1,1,3-trioxo-1,2-th...)
Show SMILES NC(=O)[C@H](Cc1ccc(cc1)C1CC(=O)NS1(=O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H28N4O6S/c29-26(34)22(15-19-11-13-20(14-12-19)24-17-25(33)32-39(24,37)38)30-28(36)23(16-18-7-3-1-4-8-18)31-27(35)21-9-5-2-6-10-21/h1-14,22-24H,15-17H2,(H2,29,34)(H,30,36)(H,31,35)(H,32,33)/t22-,23-,24?/m0/s1
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n/an/a 185n/an/an/an/a7.022



Incyte Corporation



Assay Description
The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...

J Biol Chem 281: 32784-95 (2006)


Article DOI: 10.1074/jbc.M606873200
BindingDB Entry DOI: 10.7270/Q2GX48SD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 [1-298]


(Homo sapiens (Human))		BDBM13465
PNG
((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1...)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)[C@@H]1CC(=O)NS1(=O)=O)C(N)=O |r|
Show InChI InChI=1S/C23H26N4O6S/c1-14(28)25-19(12-15-5-3-2-4-6-15)23(31)26-18(22(24)30)11-16-7-9-17(10-8-16)20-13-21(29)27-34(20,32)33/h2-10,18-20H,11-13H2,1H3,(H2,24,30)(H,25,28)(H,26,31)(H,27,29)/t18-,19-,20-/m0/s1
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n/an/a 190n/an/an/an/a7.022



Incyte Corporation



Assay Description
The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...

J Biol Chem 281: 32784-95 (2006)


Article DOI: 10.1074/jbc.M606873200
BindingDB Entry DOI: 10.7270/Q2GX48SD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 [1-298]


(Homo sapiens (Human))		BDBM13807
PNG
((2S)-N-[(1S)-1-carbamoyl-2-[4-(1,1,3-trioxo-1,2-th...)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)C1CC(=O)NS1(=O)=O)C(N)=O |r|
Show InChI InChI=1S/C23H26N4O6S/c1-14(28)25-19(12-15-5-3-2-4-6-15)23(31)26-18(22(24)30)11-16-7-9-17(10-8-16)20-13-21(29)27-34(20,32)33/h2-10,18-20H,11-13H2,1H3,(H2,24,30)(H,25,28)(H,26,31)(H,27,29)/t18-,19-,20?/m0/s1
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n/an/a 210n/an/an/an/a7.022



Incyte Corporation



Assay Description
The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...

J Biol Chem 281: 32784-95 (2006)


Article DOI: 10.1074/jbc.M606873200
BindingDB Entry DOI: 10.7270/Q2GX48SD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 [1-298]


(Homo sapiens (Human))		BDBM13806
PNG
(5-(3-hydroxyphenyl)-2,3-dihydro-1,2-thiazole-1,1,3...)
Show SMILES Oc1cccc(c1)C1=CC(=O)NS1(=O)=O |t:8|
Show InChI InChI=1S/C9H7NO4S/c11-7-3-1-2-6(4-7)8-5-9(12)10-15(8,13)14/h1-5,11H,(H,10,12)
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n/an/a 1.35E+3n/an/an/an/a7.022



Incyte Corporation



Assay Description
The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...

J Biol Chem 281: 32784-95 (2006)


Article DOI: 10.1074/jbc.M606873200
BindingDB Entry DOI: 10.7270/Q2GX48SD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 [1-298]


(Homo sapiens (Human))		BDBM13472
PNG
(({4-[(2S)-2-carbamoyl-2-[(2S)-2-acetamido-3-phenyl...)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)C(F)(F)P(O)(O)=O)C(N)=O |r|
Show InChI InChI=1S/C21H24F2N3O6P/c1-13(27)25-18(12-14-5-3-2-4-6-14)20(29)26-17(19(24)28)11-15-7-9-16(10-8-15)21(22,23)33(30,31)32/h2-10,17-18H,11-12H2,1H3,(H2,24,28)(H,25,27)(H,26,29)(H2,30,31,32)/t17-,18-/m0/s1
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n/an/a 1.75E+3n/an/an/an/a7.022



Incyte Corporation



Assay Description
The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...

J Biol Chem 281: 32784-95 (2006)


Article DOI: 10.1074/jbc.M606873200
BindingDB Entry DOI: 10.7270/Q2GX48SD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 [1-298]


(Homo sapiens (Human))		BDBM13811
PNG
((2S)-N-[(1S)-1-carbamoyl-2-[4-(1,1,3-trioxo-2,3-di...)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)C1=CC(=O)NS1(=O)=O)C(N)=O |r,t:25|
Show InChI InChI=1S/C23H24N4O6S/c1-14(28)25-19(12-15-5-3-2-4-6-15)23(31)26-18(22(24)30)11-16-7-9-17(10-8-16)20-13-21(29)27-34(20,32)33/h2-10,13,18-19H,11-12H2,1H3,(H2,24,30)(H,25,28)(H,26,31)(H,27,29)/t18-,19-/m0/s1
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PubMed
n/an/a 3.00E+3n/an/an/an/a7.022



Incyte Corporation



Assay Description
The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...

J Biol Chem 281: 32784-95 (2006)


Article DOI: 10.1074/jbc.M606873200
BindingDB Entry DOI: 10.7270/Q2GX48SD
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Tyrosine-protein phosphatase non-receptor type 1 [1-298]


(Homo sapiens (Human))		BDBM13812
PNG
((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5R)-1,1,3-trioxo-1...)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)[C@H]1CC(=O)NS1(=O)=O)C(N)=O |r|
Show InChI InChI=1S/C23H26N4O6S/c1-14(28)25-19(12-15-5-3-2-4-6-15)23(31)26-18(22(24)30)11-16-7-9-17(10-8-16)20-13-21(29)27-34(20,32)33/h2-10,18-20H,11-13H2,1H3,(H2,24,30)(H,25,28)(H,26,31)(H,27,29)/t18-,19-,20+/m0/s1
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PubMed
n/an/a 1.60E+4n/an/an/an/a7.022



Incyte Corporation



Assay Description
The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...

J Biol Chem 281: 32784-95 (2006)


Article DOI: 10.1074/jbc.M606873200
BindingDB Entry DOI: 10.7270/Q2GX48SD
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
* indicates data uncertainty>20%