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PubMed code 16970397

Compile data set for download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13307
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C25H27N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h3-11,15,18-20H,12-13,16-17H2,1-2H3
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n/an/a 0.5n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13311
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cc1ccccc1CN(CCN(Cc1cncn1C)c1ccc(cc1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C26H29N7O2S/c1-21-6-4-5-7-23(21)16-33(36(34,35)26-18-30(2)20-29-26)13-12-32(17-25-15-28-19-31(25)3)24-10-8-22(14-27)9-11-24/h4-11,15,18-20H,12-13,16-17H2,1-3H3
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n/an/a 0.600n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13309
PNG
(N-(2-{(4-bromophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(Br)cc1)Cc1ccccn1
Show InChI InChI=1S/C23H26BrN7O2S/c1-28-16-23(27-18-28)34(32,33)31(14-20-5-3-4-10-26-20)12-11-30(15-22-13-25-17-29(22)2)21-8-6-19(24)7-9-21/h3-10,13,16-18H,11-12,14-15H2,1-2H3
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n/an/a 1.90n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13308
PNG
(N-benzyl-N-(2-{(4-bromophenyl)[(1-methyl-1H-imidaz...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(Br)cc1)Cc1ccccc1
Show InChI InChI=1S/C24H27BrN6O2S/c1-28-17-24(27-19-28)34(32,33)31(15-20-6-4-3-5-7-20)13-12-30(16-23-14-26-18-29(23)2)22-10-8-21(25)9-11-22/h3-11,14,17-19H,12-13,15-16H2,1-2H3
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n/an/a 2n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13310
PNG
(N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccn1
Show InChI InChI=1S/C24H26N8O2S/c1-29-17-24(28-19-29)35(33,34)32(15-21-5-3-4-10-27-21)12-11-31(16-23-14-26-18-30(23)2)22-8-6-20(13-25)7-9-22/h3-10,14,17-19H,11-12,15-16H2,1-2H3
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n/an/a 2.10n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13315
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC1CCCCC1
Show InChI InChI=1S/C25H33N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h8-11,15,18-20,22H,3-7,12-13,16-17H2,1-2H3
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n/an/a 4.5n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13315
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC1CCCCC1
Show InChI InChI=1S/C25H33N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h8-11,15,18-20,22H,3-7,12-13,16-17H2,1-2H3
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n/an/a 7.5n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13312
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[Biphenyl...)
Show SMILES Cc1ccccc1CN(CCN(Cc1cncn1C)c1ccc(cc1)-c1ccccc1)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C31H34N6O2S/c1-25-9-7-8-12-28(25)20-37(40(38,39)31-22-34(2)24-33-31)18-17-36(21-30-19-32-23-35(30)3)29-15-13-27(14-16-29)26-10-5-4-6-11-26/h4-16,19,22-24H,17-18,20-21H2,1-3H3
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n/an/a 8n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13313
PNG
(N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H27N5O2S/c1-30-22-29-19-26(30)21-31(25-14-12-23(18-28)13-15-25)16-17-32(20-24-8-4-2-5-9-24)35(33,34)27-10-6-3-7-11-27/h2-15,19,22H,16-17,20-21H2,1H3
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n/an/a 8.90n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13313
PNG
(N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H27N5O2S/c1-30-22-29-19-26(30)21-31(25-14-12-23(18-28)13-15-25)16-17-32(20-24-8-4-2-5-9-24)35(33,34)27-10-6-3-7-11-27/h2-15,19,22H,16-17,20-21H2,1H3
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n/an/a 13n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13311
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cc1ccccc1CN(CCN(Cc1cncn1C)c1ccc(cc1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C26H29N7O2S/c1-21-6-4-5-7-23(21)16-33(36(34,35)26-18-30(2)20-29-26)13-12-32(17-25-15-28-19-31(25)3)24-10-8-22(14-27)9-11-24/h4-11,15,18-20H,12-13,16-17H2,1-3H3
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n/an/a 15.5n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13307
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C25H27N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h3-11,15,18-20H,12-13,16-17H2,1-2H3
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n/an/a 25n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13310
PNG
(N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccn1
Show InChI InChI=1S/C24H26N8O2S/c1-29-17-24(28-19-29)35(33,34)32(15-21-5-3-4-10-27-21)12-11-31(16-23-14-26-18-30(23)2)22-8-6-20(13-25)7-9-22/h3-10,14,17-19H,11-12,15-16H2,1-2H3
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n/an/a 43n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13314
PNG
(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C33H34N6O2S/c1-36(2)32-13-7-12-31-30(32)11-8-14-33(31)42(40,41)39(23-27-9-5-4-6-10-27)20-19-38(24-29-22-35-25-37(29)3)28-17-15-26(21-34)16-18-28/h4-18,22,25H,19-20,23-24H2,1-3H3
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n/an/a 55n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13309
PNG
(N-(2-{(4-bromophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(Br)cc1)Cc1ccccn1
Show InChI InChI=1S/C23H26BrN7O2S/c1-28-16-23(27-18-28)34(32,33)31(14-20-5-3-4-10-26-20)12-11-30(15-22-13-25-17-29(22)2)21-8-6-19(24)7-9-21/h3-10,13,16-18H,11-12,14-15H2,1-2H3
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n/an/a 83n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13318
PNG
(N-(4-cyanobenzyl)-N-(2-{(4-cyanophenyl)[(1-methyl-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N8O2S/c1-31-18-26(30-20-31)37(35,36)34(16-23-5-3-21(13-27)4-6-23)12-11-33(17-25-15-29-19-32(25)2)24-9-7-22(14-28)8-10-24/h3-10,15,18-20H,11-12,16-17H2,1-2H3
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n/an/a 95n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13314
PNG
(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C33H34N6O2S/c1-36(2)32-13-7-12-31-30(32)11-8-14-33(31)42(40,41)39(23-27-9-5-4-6-10-27)20-19-38(24-29-22-35-25-37(29)3)28-17-15-26(21-34)16-18-28/h4-18,22,25H,19-20,23-24H2,1-3H3
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n/an/a 180n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13316
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Biphenyl-4-y...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H31N7O2S/c1-35-22-31(34-24-35)41(39,40)38(20-26-8-12-28(13-9-26)27-6-4-3-5-7-27)17-16-37(21-30-19-33-23-36(30)2)29-14-10-25(18-32)11-15-29/h3-15,19,22-24H,16-17,20-21H2,1-2H3
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n/an/a 240n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13308
PNG
(N-benzyl-N-(2-{(4-bromophenyl)[(1-methyl-1H-imidaz...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(Br)cc1)Cc1ccccc1
Show InChI InChI=1S/C24H27BrN6O2S/c1-28-17-24(27-19-28)34(32,33)31(15-20-6-4-3-5-7-20)13-12-30(16-23-14-26-18-29(23)2)22-10-8-21(25)9-11-22/h3-11,14,17-19H,12-13,15-16H2,1-2H3
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n/an/a 290n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13318
PNG
(N-(4-cyanobenzyl)-N-(2-{(4-cyanophenyl)[(1-methyl-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N8O2S/c1-31-18-26(30-20-31)37(35,36)34(16-23-5-3-21(13-27)4-6-23)12-11-33(17-25-15-29-19-32(25)2)24-9-7-22(14-28)8-10-24/h3-10,15,18-20H,11-12,16-17H2,1-2H3
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n/an/a 350n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13316
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Biphenyl-4-y...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H31N7O2S/c1-35-22-31(34-24-35)41(39,40)38(20-26-8-12-28(13-9-26)27-6-4-3-5-7-27)17-16-37(21-30-19-33-23-36(30)2)29-14-10-25(18-32)11-15-29/h3-15,19,22-24H,16-17,20-21H2,1-2H3
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n/an/a 880n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13317
PNG
(N-tert-butyl-2-({2-[(4-cyanophenyl)[(1-methyl-1H-i...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H32N8O3S/c1-24(2,3)28-22(33)15-32(36(34,35)23-16-29(4)18-27-23)11-10-31(14-21-13-26-17-30(21)5)20-8-6-19(12-25)7-9-20/h6-9,13,16-18H,10-11,14-15H2,1-5H3,(H,28,33)
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n/an/a>1.00E+3n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13317
PNG
(N-tert-butyl-2-({2-[(4-cyanophenyl)[(1-methyl-1H-i...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H32N8O3S/c1-24(2,3)28-22(33)15-32(36(34,35)23-16-29(4)18-27-23)11-10-31(14-21-13-26-17-30(21)5)20-8-6-19(12-25)7-9-20/h6-9,13,16-18H,10-11,14-15H2,1-5H3,(H,28,33)
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n/an/a>1.00E+3n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13312
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[Biphenyl...)
Show SMILES Cc1ccccc1CN(CCN(Cc1cncn1C)c1ccc(cc1)-c1ccccc1)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C31H34N6O2S/c1-25-9-7-8-12-28(25)20-37(40(38,39)31-22-34(2)24-33-31)18-17-36(21-30-19-32-23-35(30)3)29-15-13-27(14-16-29)26-10-5-4-6-11-26/h4-16,19,22-24H,17-18,20-21H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%