Affinity Data by PubMed id=17028581

PubMed code 17028581

Found 3 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM8053 (2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 \| 4...) Show SMILES Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	7.5	20
University of Cambridge					Assay Description D. melanogaster Polo kinase assays were performed as previously described40, using baculovirus-expressed Polo kinase. Enzyme was immunoprecipitated u...				Nat Chem Biol 2: 608-17 (2006) Article DOI: 10.1038/nchembio825 BindingDB Entry DOI: 10.7270/Q29C6VS4
University of Cambridge					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM8054 (2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 25 \| 4...) Show SMILES CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	7.5	20
University of Cambridge					Assay Description D. melanogaster Polo kinase assays were performed as previously described40, using baculovirus-expressed Polo kinase. Enzyme was immunoprecipitated u...				Nat Chem Biol 2: 608-17 (2006) Article DOI: 10.1038/nchembio825 BindingDB Entry DOI: 10.7270/Q29C6VS4
University of Cambridge					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM8055 (2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 26 \| 4...) Show SMILES Cc1nc(N)sc1-c1ccnc(Nc2ccc(O)cc2)n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	7.5	20
University of Cambridge					Assay Description D. melanogaster Polo kinase assays were performed as previously described40, using baculovirus-expressed Polo kinase. Enzyme was immunoprecipitated u...				Nat Chem Biol 2: 608-17 (2006) Article DOI: 10.1038/nchembio825 BindingDB Entry DOI: 10.7270/Q29C6VS4
University of Cambridge					More data for this Ligand-Target Pair

* indicates data uncertainty>20%