Found 12 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50196289
(6-(4-methoxyphenyl)-5-methyl-3-phenylisoxazolo[4,5...)Show InChI InChI=1S/C20H16N2O3/c1-22-16(13-8-10-15(24-2)11-9-13)12-17-18(20(22)23)19(21-25-17)14-6-4-3-5-7-14/h3-12H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371204
(CHEMBL247478)Show SMILES CC(C)OCCOCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C Show InChI InChI=1S/C25H26N2O4/c1-17(2)30-14-13-29-16-18-9-11-19(12-10-18)21-15-22-23(25(28)27(21)3)24(26-31-22)20-7-5-4-6-8-20/h4-12,15,17H,13-14,16H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 113 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371205
(CHEMBL393713)Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3onc(-c4ccccc4)c3c(=O)n2C)CC1 Show InChI InChI=1S/C25H26N4O2/c1-27-12-14-29(15-13-27)17-18-8-10-19(11-9-18)21-16-22-23(25(30)28(21)2)24(26-31-22)20-6-4-3-5-7-20/h3-11,16H,12-15,17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 31.9 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371203
(CHEMBL247263)Show InChI InChI=1S/C14H12N2O2/c1-9-8-11-12(14(17)16(9)2)13(15-18-11)10-6-4-3-5-7-10/h3-8H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371206
(CHEMBL401032)Show SMILES COCCOCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C Show InChI InChI=1S/C23H22N2O4/c1-25-19(17-10-8-16(9-11-17)15-28-13-12-27-2)14-20-21(23(25)26)22(24-29-20)18-6-4-3-5-7-18/h3-11,14H,12-13,15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371202
(CHEMBL393714)Show InChI InChI=1S/C18H13N3O2/c1-21-14(12-7-9-19-10-8-12)11-15-16(18(21)22)17(20-23-15)13-5-3-2-4-6-13/h2-11H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50196291
(6-(benzo[d][1,3]dioxol-5-yl)-5-methyl-3-phenylisox...)Show SMILES Cn1c(cc2onc(-c3ccccc3)c2c1=O)-c1ccc2OCOc2c1 Show InChI InChI=1S/C20H14N2O4/c1-22-14(13-7-8-15-16(9-13)25-11-24-15)10-17-18(20(22)23)19(21-26-17)12-5-3-2-4-6-12/h2-10H,11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371201
(CHEMBL399807)Show SMILES Cn1c(cc2onc(-c3ccccc3)c2c1=O)-c1ccc(COCCO)cc1 Show InChI InChI=1S/C22H20N2O4/c1-24-18(16-9-7-15(8-10-16)14-27-12-11-25)13-19-20(22(24)26)21(23-28-19)17-5-3-2-4-6-17/h2-10,13,25H,11-12,14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371207
(CHEMBL247676)Show SMILES Cn1c(cc2onc(-c3ccccc3)c2c1=O)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H18N2O3/c1-27-21(17-12-14-20(15-13-17)29-19-10-6-3-7-11-19)16-22-23(25(27)28)24(26-30-22)18-8-4-2-5-9-18/h2-16H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371208
(ISOXAZOLOPYRIDINONE)Show InChI InChI=1S/C18H12N2O2/c21-18-16-15(11-14(19-18)12-7-3-1-4-8-12)22-20-17(16)13-9-5-2-6-10-13/h1-11H,(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 77.5 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371209
(CHEMBL246654)Show SMILES COc1ccc(c(OC)c1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C Show InChI InChI=1S/C21H18N2O4/c1-23-16(15-10-9-14(25-2)11-17(15)26-3)12-18-19(21(23)24)20(22-27-18)13-7-5-4-6-8-13/h4-12H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 59.2 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human)) | BDBM50371210
(CHEMBL247879)Show SMILES CN(C)Cc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C Show InChI InChI=1S/C22H21N3O2/c1-24(2)14-15-9-11-16(12-10-15)18-13-19-20(22(26)25(18)3)21(23-27-19)17-7-5-4-6-8-17/h4-13H,14H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Activation of Nurr1 expressed in MN9D cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 17: 193-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.062
BindingDB Entry DOI: 10.7270/Q23T9J2R |
More data for this
Ligand-Target Pair | |
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