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PubMed code 17088057

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50197974
PNG
(udp-N-acetyl-glucosamine)
Show SMILES CC(=O)N[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1OP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8+,10-,11-,12+,13-,14+,15+,16-/m0/s1
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PubMed
n/an/an/an/a 4.38E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC

Bioorg Med Chem Lett 17: 761-6 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.081
BindingDB Entry DOI: 10.7270/Q2KW5GW6
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50197975
PNG
(udp-glucuronic acid)
Show SMILES O[C@@H]1[C@@H](COP([O-])(=O)OP([O-])(=O)O[C@@H]2O[C@H]([C@H](O)[C@@H](O)[C@@H]2O)C(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H22N2O18P2/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26)/p-2/t4-,6-,7-,8-,9-,10+,11-,12-,14+/m1/s1
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n/an/an/an/a 370n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC

Bioorg Med Chem Lett 17: 761-6 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.081
BindingDB Entry DOI: 10.7270/Q2KW5GW6
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50370674
PNG
(UDP-GALACTOSE)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)c2cc(=O)[nH]c(=O)[nH]2)[C@H](O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H24N2O17P2/c18-2-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-3-6-9(21)11(23)13(31-6)4-1-7(19)17-15(25)16-4/h1,5-6,8-14,18,20-24H,2-3H2,(H,26,27)(H,28,29)(H2,16,17,19,25)/t5-,6-,8+,9-,10+,11-,12-,13+,14-/m1/s1
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n/an/an/an/a 671n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC

Bioorg Med Chem Lett 17: 761-6 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.081
BindingDB Entry DOI: 10.7270/Q2KW5GW6
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50423218
PNG
(5''-Diphosphoglucose | UDPG | URIDINE DIPHOSPHATE ...)
Show SMILES OC[C@H]1O[C@H](O[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
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MCE
KEGG
MMDB
PC cid
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PDB
UniChem

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PubMed
n/an/an/an/a 354n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC

Bioorg Med Chem Lett 17: 761-6 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.081
BindingDB Entry DOI: 10.7270/Q2KW5GW6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%