Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18497 (6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)but-1-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18498 (6-methyl-5-[(3S)-3-(3,4,5-trimethoxyphenyl)but-1-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18497 (6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)but-1-y...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18492 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18492 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-y...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 169 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18496 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 550 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18490 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 880 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18498 (6-methyl-5-[(3S)-3-(3,4,5-trimethoxyphenyl)but-1-y...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.91E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18491 (5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18496 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18491 (5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimid...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18494 (3-(2,4-diamino-6-methylpyrimidin-5-yl)-1-(3,4,5-tr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18495 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18490 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18493 (3-(2,4-diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyp...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.79E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18489 (5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-yl]pyrimi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.17E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18489 (5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-yl]pyrimi...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.61E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM18488 (5-[2-(3,4,5-trimethoxyphenyl)ethyl]pyrimidine-2,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.02E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18495 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18494 (3-(2,4-diamino-6-methylpyrimidin-5-yl)-1-(3,4,5-tr...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.41E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18493 (3-(2,4-diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyp...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.94E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18486 (5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]pyrimidin...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18487 (5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]pyrimidin...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18485 (5-[2-(3,4,5-trimethoxyphenyl)ethynyl]pyrimidine-2,...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis) | BDBM18488 (5-[2-(3,4,5-trimethoxyphenyl)ethyl]pyrimidine-2,4-...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Dartmouth College | Assay Description Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa... | J Med Chem 50: 940-50 (2007) Article DOI: 10.1021/jm061027h BindingDB Entry DOI: 10.7270/Q2KH0KKQ | |||||||||||
More data for this Ligand-Target Pair |